Mind-life continuity: A qualitative study of conscious experience

Hipólito, Inês; Martins, Jorge

doi:10.1016/j.pbiomolbio.2017.09.004

Cited by 4 publications

(28 citation statements)

References 44 publications

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“…The study is a non-representative, descriptive study with a two-grouped, four-setting, single-blinded and post-test design. Please refer to Hipólito and Martins’s study [ 49 ] for a complete description of the study design. The experiment is controlled, multicentered, and approved by the Ethics Committee of the Faculty of Medicine, University of Lisbon.…”

Section: Methodsmentioning

confidence: 99%

“…In this paper, we advanced with the previously published methodology [ 49 ], using the same participants, basing our methods on the stratification of neurotypical subjects into subclinical groups [ 7 , 14 , 20 , 33 , 34 , 36 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 ].…”

Section: Methodsmentioning

confidence: 99%

“…Please refer to Hipólito and Martins [ 49 ] for a complete statistical strategy and sample size estimation. The primary outcome of this work is to observe if there is a molecular correlation to mental health stratification.…”

Section: Methodsmentioning

confidence: 99%

“…“A plurally constituted approach can be rigorously formulated to accommodate qualitative analysis and quantitative measurements” [ 49 ]. Physiological mechanisms have described that phenomes composed of strong emotional states also modify the protein biomarker profile [ 50 ].…”

Section: Introductionmentioning

confidence: 99%

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Pre-Molecular Assessment of Self-Processes in Neurotypical Subjects Using a Single Cognitive Behavioral Intervention Evoking Autobiographical Memory

Martins

Simões

Barros

et al. 2022

Behavioral Sciences

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In the last 20 years, several contributions have been published on what concerns the conceptual and empirical connections between self-processes. However, only a limited number of publications addressed the viability of those processes to characterize mental health in neurotypical subjects with a normative pattern of neurodevelopment. Furthermore, even fewer experiments focused explicitly on the complexity of studying neurotypical phenomenal data. On the one hand, this normative pattern is commonly associated with mental health and a multifaceted self-concept and well-being. On the other hand, well-being is often related to a healthy cognitive life. However, how such intricate and complex relation between self-processes is established in neurotypical subjects requires further evidence. The novelty of this work is thus studying the first-person experience, which is correlated with the mental events aroused by a cognitive behavioral intervention. The prior methodology that led to the complete characterization of a neurotypical sample was already published by the authors, although the materials, the methods, the sample screening, and the sample size study required further explanation and exploration. This paper’s innovation is hence the phenomenological assessment of subjects’ self-regulation, which is used for mental health profiling, providing the basis for subsequent molecular typing. For that matter, a convenience sample of 128 (19–25-year-old) neurotypical young adults, healthy university students at the University of Lisbon, non-medicated and with no serious, uncontrolled, or chronic diseases, are characterized according to their cognitive functioning and self-concept. The procedure comprised (i) a mental status examination (psychological assessment) and (ii) a psychological intervention, i.e., a single cognitive behavioral intervention (intervention protocol). The psychological assessment was a standardized and structured clinical interview, which comprised the use of 4 psychological scales complementary to the classical Mental Status Examination (MSE). The intervention protocol applied a combined exercise of psychophysical training and autobiographical-self memory-recalling. The results permitted identifying and isolating four different subgroups (self awareness, self consciousness, reflective self, and pre-reflective self) in neurotypical subjects with discrete self-processes. The outcome of this study is screening four different aspects of self-reflection and the isolation between various forms of self-directed attention and their interconnections in these four mental health strata. The practical implication of this study is to fulfill an a priori pre-molecular assessment of self-regulation with separate cognitive characteristics. The reliability of these mental strata, their distinct neurophysiology, and discrete molecular fingerprint will be tested in a future publication by in silico characterization, total protein profiling, and simultaneous immunodetection of the neuropeptide and neuroimmune response of the same participants.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pre-Molecular Assessment of Self-Processes in Neurotypical Subjects Using a Single Cognitive Behavioral Intervention Evoking Autobiographical Memory

Martins

Simões

Barros

et al. 2022

Behavioral Sciences

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show abstract

“…Genes however do not code for proteins (e.g., epigenetic transcription factors, the overall healthy and normal functioning of the cell, that cell's being embedded in an organism, etc.) (Rosch et al 1991;Godfrey-Smith 2007;Woodward;Griffiths and Stotz 2013;Hipólito and Martins 2017). Analogously, the weak instructionist framework for motor representation says that skillful performance is the result of an orchestrated process spanning components in the brain, body, and world, but that of these components, some special structures in the brain play the specific, explanatorily irreducible role of encoding explicit instructions for motor performance.…”

Section: The Instructionist Model Of Skillful Performancementioning

confidence: 99%

Embodied skillful performance: where the action is

et al. 2021

Self Cite

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When someone masters a skill, their performance looks to us like second nature: it looks as if their actions are smoothly performed without explicit, knowledge-driven, online monitoring of their performance. Contemporary computational models in motor control theory, however, are instructionist: that is, they cast skillful performance as a knowledge-driven process. Optimal motor control theory (OMCT), as representative par excellence of such approaches, casts skillful performance as an instruction, instantiated in the brain, that needs to be executed—a motor command. This paper aims to show the limitations of such instructionist approaches to skillful performance. We specifically address the question of whether the assumption of control-theoretic models is warranted. The first section of this paper examines the instructionist assumption, according to which skillful performance consists of the execution of theoretical instructions harnessed in motor representations. The second and third sections characterize the implementation of motor representations as motor commands, with a special focus on formulations from OMCT. The final sections of this paper examine predictive coding and active inference—behavioral modeling frameworks that descend, but are distinct, from OMCT—and argue that the instructionist, control-theoretic assumptions are ill-motivated in light of new developments in active inference.

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A “Second-Person” Model to Anomalous Social Cognition

Hipólito

Martins

2018

Schizophrenia and Common Sense

Self Cite

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Reports of patients with schizophrenia or a psychotic functioning show evidence of a fragmented and anomalous subjective experience. This pathological subjective experience may be related to the fact that a disembodiment inhibits the possibility of intersubjective experience, and more importantly of common sense. In this paper, we ask how can we investigate the anomalous experience both from qualitative and quantitative viewpoints. To our knowledge, few studies have focused on a clinical combination of both phenomenological assessment and biological methods, especially for Schizophrenia, or ASD therapeutics and diagnosis. We will claim qualities of perception and kinaesthetic phenomena are central features when considering human experience in general, and anomalous experience, in particular. We will thus attempt to bring forward a potential second-person scientific design, accounting for both the first-person subjective experiential aspects, and respective third-person neurobiological correlates of embodied aesthetics in anomalous experience. From this proposal, we further explore the consequences to clinical and research practice.

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Mind-life continuity: A qualitative study of conscious experience

Cited by 4 publications

References 44 publications

Pre-Molecular Assessment of Self-Processes in Neurotypical Subjects Using a Single Cognitive Behavioral Intervention Evoking Autobiographical Memory

Pre-Molecular Assessment of Self-Processes in Neurotypical Subjects Using a Single Cognitive Behavioral Intervention Evoking Autobiographical Memory

Embodied skillful performance: where the action is

A “Second-Person” Model to Anomalous Social Cognition

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