Mind the B2: Life-Threatening Neonatal Complications of a Strict Vegan Diet during Pregnancy

Jaeger, Bregje; Corpeleijn, Willemijn E.; Dijsselhof, Monique E.; Goorden, Susan; Haverkamp, Jorien A.; Langeveld, Mirjam; Waterham, Hans R.; Westerbeek, Elisabeth A. M.; Bosch, Annet M.

doi:10.1159/000526334

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…The mother followed a strict vegan diet with occasional supplementation of vitamin B12, folic acid, vitamin D, and omega-3. This case highlights the importance of riboflavin intake for pregnant women on a vegan diet [ 10 ].…”

Section: Resultsmentioning

confidence: 99%

Vegan Diet in Dermatology: A Review

Lee,

Sim,

Fotouhi

et al. 2023

JCM

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Diet is known to play a role in the development of skin disorders. While a vegan diet is frequently described as a risk factor for skin disease secondary to nutritional deficiency, this risk may be overestimated. This review aims to debunk myths and provide information on skin disorders and inflammatory skin conditions that have associations with specific nutritional deficiencies in the context of a vegan diet. A literature search was performed for each nutrient and inflammatory skin disease using the PubMed/MEDLINE database and public health website pages concerning a vegan diet. The literature has individual cases reporting skin disease due to deficiencies in vitamin B2 and vitamin A in patients following a vegan diet. The recommended daily amounts of nutrients and vitamins can be fulfilled on a vegan diet. Vegan diets also avoid food groups such as dairy and other animal-based products, which holds benefits in inflammatory skin diseases including acne, psoriasis, hidradenitis suppurativa, and atopic dermatitis. Overall, the risk of skin disease secondary to nutritional deficiency in patients following a vegan diet is very low and likely over-emphasized. A well-balanced and conscientiously planned vegan diet can adequately provide the necessary amounts of proteins, vitamins, and minerals to support skin health.

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Section: Resultsmentioning

confidence: 99%

Vegan Diet in Dermatology: A Review

Lee,

Sim,

Fotouhi

et al. 2023

JCM

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“…Clinical signs of riboflavin deficiency in humans appear after several months of dietary intakes of less than 0.5-0.6 mg/day (50). Of concern, one case report just published describes a life-threatening condition of hypoglycemia and lactic acidosis due to severe riboflavin deficiency in a neonate caused by riboflavin deficiency resulting from a maternal vegan diet (51).…”

Section: Riboflavin Deficiency In Humans Deficiency Signsmentioning

confidence: 99%

Causes and Clinical Sequelae of Riboflavin Deficiency

McNulty,

Pentieva,

Ward

2023

Annu. Rev. Nutr.

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Riboflavin, in its cofactor forms flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), plays fundamental roles in energy metabolism, cellular antioxidant potential, and metabolic interactions with other micronutrients, including iron, vitamin B6, and folate. Severe riboflavin deficiency, largely confined to low-income countries, clinically manifests as cheilosis, angular stomatitis, glossitis, seborrheic dermatitis, and severe anemia with erythroid hypoplasia. Subclinical deficiency may be much more widespread, including in high-income countries, but typically goes undetected because riboflavin biomarkers are rarely measured in human studies. There are adverse health consequences of low and deficient riboflavin status throughout the life cycle, including anemia and hypertension, that could contribute substantially to the global burden of disease. This review considers the available evidence on causes, detection, and consequences of riboflavin deficiency, ranging from clinical deficiency signs to manifestations associated with less severe deficiency, and the related research, public health, and policy priorities.

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