Mindfulness-based and acceptance-based programmes in the treatment of obsessive–compulsive disorder: a study protocol for a systematic review and meta-analysis

Abstract

IntroductionCognitive–behavioural therapy (CBT) with exposure and response prevention is the recommended standard for the treatment of obsessive–compulsive disorder (OCD). However, a high proportion of patients refuse this treatment, do not respond or relapse shortly after treatment. Growing evidence suggests that mindfulness-based and acceptance-based programmes (MABPs) are an effective option for the treatment of OCD. This systematic review and meta-analysis will examine the effectiveness of MABPs in treating OCD. We also aimed to explore potential moderators of the programmes’ effectiveness.Methods and analysisWe will systematically search MEDLINE, Embase, PsycINFO, PSYINDEX, Web of Science, CINAHL and Cochrane Register of Controlled Trials (no language restrictions) for studies that evaluate the effect of MABPs on patients with OCD. We will conduct backward and forward citation searches of included studies and relevant reviews and contact corresponding authors. The primary outcome will be pre-post intervention change in symptom severity. A secondary outcome will be change in depressive symptoms. Two reviewers will independently screen the records, extract the data and rate the methodological quality of the studies. We will include both controlled and uncontrolled trials. Randomised controlled trials will be meta-analysed, separately assessing between-group effects. A second meta-analysis will assess the within-group effect of all eligible studies. We will explore moderators and sources of heterogeneity such as the specific programme, study design, changes in depressive symptoms, hours of guided treatment, control condition and prior therapy (eg, CBT) using metaregression and subgroup analyses. We will perform sensitivity analyses using follow-up data. A narrative synthesis will also be pursued. We will use the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to assess the quality of the evidence.Ethics and disseminationEthical approval is not required. Results will be published in peer-reviewed journals and presented at international conferences.

Effects of acceptance-based strategies on psychological responses to disorder-relevant stimuli in inpatients with obsessive–compulsive disorder: An experimental study

“…However, many patients find it difficult to endure upcoming unpleasant feelings, cognitions, and bodily sensations (Reid et al, 2017). Therefore, a substantial number of patients refuse ERP, drop out prematurely, do not adhere to treatment instructions, do not achieve clinically significant reductions in symptom severity, or relapse shortly after treatment (Bürkle et al, 2021). Thus, there is a need to develop ways to increase treatment acceptability, adherence, and consistency of treatment response.…”

Mindfulness for internet use disorder: a study protocol of a systematic review and meta-analysis

“…We will prepare the report of the final systematic review and meta-analysis in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines 25. We will follow the methodology established by the authors in previous reviews 26 27…”

“…In October 2022, we will search Medline, PsycINFO, PSYINDEX, CINAHL, Web of Science, and Cochrane Register of Controlled Trials without language or publication date restrictions. We will translate articles in languages other than English, German, or French with the help of neural machine translation, as we did in previous reviews 26 27. Search terms will be related to (1) mindfulness or MBPs and (2) IUD, using text words and subject headings (including MeSH terms).…”