Mineral Trioxide Aggregate: A Comprehensive Literature Review—Part II: Leakage and Biocompatibility Investigations

Torabinejad, Mahmoud; Parirokh, Masoud

doi:10.1016/j.joen.2009.09.010

Cited by 749 publications

(626 citation statements)

References 224 publications

Supporting

Mentioning

577

Contrasting

Unclassified

Order By: Relevance

“…The solubilization of the cement is an important factor for its bioactivity, particularly due to the distribution of Ca and hydroxyl ions on the pulp tissue (3,5,30). Previous studies demonstrated that the hydration process of EndoBinder and MTA accentuates the release of Ca and hydroxyl ions, which are the main components found in soluble and insoluble residues of these cements (3,5,30), with an effective participation in the tissue repair process.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity of New Calcium Aluminate Cement (EndoBinder) Containing Different Radiopacifiers

et al. 2017

View full text Add to dashboard Cite

This study aimed to evaluate the cytotoxicity of a calcium aluminate cement (EndoBinder) containing different radiopacifiers, Bi 2 O 3 , ZnO or ZrO 2 , compared with Mineral Trioxide Aggregate (MTA). According to ISO 10993-12:2012 (E) recommendations, 0.2 g of each cement were applied in transwell inserts and placed in 24-well culture plates containing 1 mL of culture medium (DMEM). After 24 h of incubation, the extracts (DMEM containing components released from the cements) were applied to immortalized odontoblast-like MDPC-23 cells. Cell viability (MTT test), alkaline phosphatase activity (ALP), total protein production and cell morphology (Scanning Electron Microscopy -SEM) were evaluated. The volume of 50 µL of extract was used to determine the chemical elements released by the cements using Energy Dispersive Spectroscopy (EDS). The following groups were established (n=6): NC -negative control (without treatment); EB -EndoBinder without radiopacifier; EBBO -EndoBinder+Bi 2 O 3 ; EBZnO -EndoBinder+ZnO; EBZrOEndoBinder+ZrO 2 and WMTA -White MTA. Data were subjected to statistical analysis (Kruskal-Wallis test, level of significance=5%). Cells exposed to the different versions of EndoBinder presented small reduction in viability, total protein production and ALP activity, with values similar to the NC and WMTA groups (p>0.05). Different elements (C, O, Na, Al, P, Si, Cl, Bi, K) released by the cements were detected in the extracts. However, the cells had no significant changes in their morphology. EndoBinder and MTA did not affect negatively the metabolism of the odontoblastic-like cells, showing it to be cytocompatible, irrespective of the used radiopacifier.

show abstract

Section: Discussionmentioning

confidence: 99%

Cytotoxicity of New Calcium Aluminate Cement (EndoBinder) Containing Different Radiopacifiers

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In the last decade, mineral trioxide aggregate (MTA), a calcium silicate-based material, became popular in endodontics as a root-end filling and pulp-capping material for the repair of root canal perforations and for apexification (1,2). MTA is a biocompatible, non-cytotoxic, non-mutagenic, non-genotoxic and non-carcinogenic material (2).…”

Section: Introductionmentioning

confidence: 99%

“…MTA is a biocompatible, non-cytotoxic, non-mutagenic, non-genotoxic and non-carcinogenic material (2). In addition, MTA has shown antibacterial and excellent sealing properties (1,2).…”

Section: Introductionmentioning

confidence: 99%

“…MTA is a biocompatible, non-cytotoxic, non-mutagenic, non-genotoxic and non-carcinogenic material (2). In addition, MTA has shown antibacterial and excellent sealing properties (1,2). However, despite its favorable characteristics, MTA does not exhibit the physical properties required for an endodontic sealer, because of its working time, setting time and difficult handling (3).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Long-Term Cytotoxicity, pH and Dissolution Rate of AH Plus and MTA Fillapex

et al. 2016

View full text Add to dashboard Cite

The aim of the present study was to verify the long-term cytotoxic effects of the MTA Fillapex and to compare them with AH Plus. Dissolution rate and pH were also evaluated. Human osteoblast cells were incubated with elutes of fresh specimens from AH Plus and MTA Fillapex, and with elutes of the same specimens for 4 successive weeks. Elute's pH was evaluated at each time point. A multiparametric cell viability assay was performed. For dissolution rate, ISO methodology was used. The results were analyzed by one-way analysis of variance, complemented with the Tukey post-test (p<0.05). No significant difference was found among the materials when fresh mixed (p>0.05). After 1 week, AH Plus became non-cytotoxic on all three evaluated parameters. Conversely, MTA Fillapex remained severely and mildly cytotoxic over the entire experimental period (p<0.05). The dissolution rate of AH Plus was significantly lower than MTA Fillapex at all time points (p>0.05). The pH of AH Plus was significantly lower than MTA Fillapex at the second and third week (p<0.05). In the other tested time points no statistical difference was observed.In conclusion, MTA Fillapex remained cytotoxic after 4 weeks and its cytotoxicity may be related to the high dissolution rate of this material.

show abstract

“…Mineral trioxide aggregate is a recent biomaterial for use in vital pulp treatment for permanent teeth [29] It is postulated that the Biocompatible MTA provides an impenetrable barrier against all future microbial leakage into remaining vital pulp [30].…”

Section: International Journal Of Dental Sciences and Researchmentioning

confidence: 99%

Tissue Engineering: An Analogous Platelet Rich Fibrin for Coronal Pulpotomy in Revival of Pulp Tissue Vitality in Adult Molar with Pulpitis, a Case Report

Aleid¹

2018

IJDSR

View full text Add to dashboard Cite

Aim: management of a clinical case with irreversible pulpitis for young adult molar with closed apices using analogous blood derivative PRF and evaluating the clinical and radiographic success for coronal pulpotomy. Summary: A 18 years old male patient reported to the screening clinic, was referred to endodontic clinic with acute pulpitis diagnosed in left first molar tooth. Deep occlusal caries involving pulp, with history of spontaneous lingering pain associated with sign and symptoms of pulpitis. Standard clinical care protocol was strictly implemented, rubber dam isolation was followed by coronal pulpotomy. Blood drawn from cuboidal vein. Platelet rich fibrin membrane placed over the remaining pulp and restored with MTA and finally with Glass ionomer cement. Follow-up results clinically and radio-graphically were encouraging and successful at day 1 to 24 months. No postoperative pain, the treated tooth responded to pulp sensibility test and radiographs revealed periapical healing. However, for standardization of the clinical procedure well designed research study is further needed.

show abstract

Mineral Trioxide Aggregate: A Comprehensive Literature Review—Part II: Leakage and Biocompatibility Investigations

Cited by 749 publications

References 224 publications

Cytotoxicity of New Calcium Aluminate Cement (EndoBinder) Containing Different Radiopacifiers

Cytotoxicity of New Calcium Aluminate Cement (EndoBinder) Containing Different Radiopacifiers

Long-Term Cytotoxicity, pH and Dissolution Rate of AH Plus and MTA Fillapex

Tissue Engineering: An Analogous Platelet Rich Fibrin for Coronal Pulpotomy in Revival of Pulp Tissue Vitality in Adult Molar with Pulpitis, a Case Report

Contact Info

Product

Resources

About