Mineral Trioxide Aggregate—A Review

Rao, Arathi; Rao, Ashwini; Shenoy, Ramya

doi:10.17796/jcpd.34.1.n1t0757815067g83

Cited by 37 publications

(24 citation statements)

References 4 publications

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“…In fact, our data show that human mesenchymal stem cells perform better on human versus bovine dental discs (see Supplementary Figure in Supplementary Material available online at http://dx.doi.org/10.1155/2015/189872). Finally, MTA which is composed of inorganic materials [39] was found to preserve the morphology of dental mesenchymal stem cells and favor their adherence and growth. Further investigation needs to be performed to identify the exact molecular mechanisms that dictate the cell growth, migration, and morphology in the presence of the different dental material.…”

Section: Discussionmentioning

confidence: 99%

Dental Stem Cell Migration on Pulp Ceiling Cavities Filled with MTA, Dentin Chips, or Bio-Oss

Lymperi

Taraslia

Tsatsoulis

et al. 2015

BioMed Research International

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MTA, Bio-Oss, and dentin chips have been successfully used in endodontics. The aim of this study was to assess the adhesion and migration of dental stem cells on human pulp ceiling cavities filled with these endodontic materials in an experimental model, which mimics the clinical conditions of regenerative endodontics. Cavities were formed, by a homemade mold, on untouched third molars, filled with endodontic materials, and observed with electron microscopy. Cells were seeded on cavities' surface and their morphology and number were analysed. The phenomenon of tropism was assessed in a migration assay. All three materials demonstrated appropriate microstructures for cell attachment. Cells grew on all reagents, but they showed a differential morphology. Moreover, variations were observed when comparing cells numbers on cavity's filling versus the surrounding dentine disc. The highest number of cells was recorded on dentin chips whereas the opposite was true for Bio-Oss. This was confirmed in the migration assay where a statistically significant lower number of cells migrated towards Bio-Oss as compared to MTA and dentin chips. This study highlights that MTA and dentin chips have a greater potential compared to Bio-Oss regarding the attraction of dental stem cells and are good candidates for bioengineered pulp regeneration.

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Section: Discussionmentioning

confidence: 99%

Dental Stem Cell Migration on Pulp Ceiling Cavities Filled with MTA, Dentin Chips, or Bio-Oss

Lymperi

Taraslia

Tsatsoulis

et al. 2015

BioMed Research International

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“…MTA was approved for use in endodontic treatment by the US Food and Drug Administration in 1998, and ProRoot MTA ® (Dentsply, Tulsa Dental Products, Tulsa, OK, USA) was the first commercial MTA product introduced in the dental market. There have been several reports on the good biocompatibility and favorable physicochemical properties of MTA 7,8) , and the product has been associated with favorable outcomes in vital pulp therapy 2,3) . However, there are some limitations associated with clinical application of MTA.…”

Section: Introductionmentioning

confidence: 99%

Biological efficacy of two mineral trioxide aggregate (MTA)-based materials in a canine model of pulpotomy

Lee

Kang

Song

et al. 2017

Dental Materials Journal

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The aim of this study was to compare the biocompatibility of Endocem Zr ® and ProRoot MTA ® by histopathologic analysis in a canine model of pulpotomy. This study utilized 39 teeth of two beagle dogs. The exposed pulp tissues were treated by pulpotomy using ProRoot MTA (n=19) or Endocem Zr (n=20). After 8 weeks, the teeth were extracted and processed with hematoxylin-eosin staining for histologic evaluation. Most of the specimens in both groups developed a calcific barrier at the pulp amputation site and formed an odontoblast layer. However, some of the Endocem Zr specimens showed less calcific barrier formation with a greater inflammatory response and less odontoblast layer formation when compared with the ProRoot MTA specimens. ProRoot MTA and Endocem Zr specimens developed a calcific barrier; however, ProRoot MTA was more biocompatible than Endocem Zr.

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“…Resin-containing composite materials release toxic monomers and shrink during polymerization (1). Since the introduction of mineral trioxide aggregate (MTA) (Dentsply Tulsa Dental Specialties, Tulsa, OK) into the field of root repair materials (2), calcium silicate-based materials have attracted considerable attention (3)(4)(5)(6)(7)(8) owing to their superior sealing ability, biocompatibility, regenerative capabilities, and antibacterial properties (4,6,(9)(10)(11)(12). Thus, they have been widely used both as endodontic repair materials and as dentin substitutes (13).…”

mentioning

confidence: 99%

In Vitro Cytotoxicity Evaluation of a Novel Root Repair Material

Zhou

Shen

Wang

et al. 2013

Journal of Endodontics

164

117

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Introduction: This study examined the effect of a new bioactive dentin substitute material (Biodentine) on the viability of human gingival fibroblasts. Methods: Biodentine, White ProRoot mineral trioxide aggregate (MTA), and glass ionomer cement were evaluated. Human gingival fibroblasts were incubated for 1, 3, and 7 days both in the extracts from immersion of set materials in culture medium and directly on the surface of the set materials immersed in culture medium. Fibroblasts cultured in Dulbecco modified Eagle medium were used as a control group. Cytotoxicity was evaluated by flow cytometry, and the adhesion of human gingival fibroblasts to the surface of the set materials was assessed by using scanning electron microscopy. The data of cell cytotoxicity were analyzed statistically by using a one-way analysis of variance test at a significance level of P < .05. Results: Cells exposed to extracts from Biodentine and MTA showed the highest viabilities at all extract concentrations, whereas cells exposed to glass ionomer cement extracts displayed the lowest viabilities (P < .05). There was no significant difference in cell viabilities between Biodentine and MTA during the entire experimental period (P > .05). Human gingival fibroblasts in contact with Biodentine and MTA attached to and spread over the material surface after an overnight culture and increased in numbers after 3 and 7 days of culture. Conclusions: Biodentine caused gingival fibroblast reaction similar to that by MTA. Both materials were less cytotoxic than glass ionomer cement. (J Endod 2013;39:478-483)

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Mineral Trioxide Aggregate—A Review

Cited by 37 publications

References 4 publications

Dental Stem Cell Migration on Pulp Ceiling Cavities Filled with MTA, Dentin Chips, or Bio-Oss

Dental Stem Cell Migration on Pulp Ceiling Cavities Filled with MTA, Dentin Chips, or Bio-Oss

Biological efficacy of two mineral trioxide aggregate (MTA)-based materials in a canine model of pulpotomy

In Vitro Cytotoxicity Evaluation of a Novel Root Repair Material

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