Mini Tablets: A Short Review-Revision

Ilhan, Ezgi; Uğurlu, Timuçin; Kerımoğlu, Oya

doi:10.17352/ojc.000007

Cited by 2 publications

(2 citation statements)

References 51 publications

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“…Minitablets (1-3 mm in diameter) are smaller than conventional tablets, making them easier to swallow for older children. Microparticles, however, may be used to increase the stability and bioavailability of an API compared to standard dosage forms and their small size makes them easier to swallow and spread throughout the GIT compared to minitablets [9,11,13,14]. Methods of microencapsulation such as phase separation and spray drying are more complex than emulsion solvent evaporation (ESE), which is a simple, easily scalable approach that results in lower residual solvent levels in particles [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…The benefits of SODF such as microparticulate or oro-dispersible dosage forms include dose flexibility and titration, ease of ingestion and enhanced patient adherence [ 6 , 7 ]. Efforts have been put into the development of multiparticulate dosage forms such as minitablets and microparticles [ 8 , 9 ]. Microparticles are solid dosage forms in which an active pharmaceutical ingredient (API) is incorporated into a polymeric matrix formed into spherical or irregular shaped particles between 1–1000 μm in size.…”

Section: Introductionmentioning

confidence: 99%

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Formulation and Characterisation of a Combination Captopril and Hydrochlorothiazide Microparticulate Dosage Form

2020

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Cardiovascular diseases such as hypertension and cardiac failure in South African children and adolescents are effectively managed long term, using a combination treatment of captopril and hydrochlorothiazide. The majority of commercially available pharmaceutical products are designed for adult patients and require extemporaneous manipulation, prior to administration to paediatric patients. There is a need to develop an age appropriate microparticulate dosing technology that is easy to swallow, dose and alter doses whilst overcoming the pharmacokinetic challenges of short half-life and biphasic pharmacokinetic disposition exhibited by hydrochlorothiazide and captopril. An emulsion solvent evaporation approach using different combinations of polymers was used to manufacture captopril and hydrochlorothiazide microparticles. Design of experiments was used to develop and analyse experimental data, and identifyoptimum formulation and process conditions for the preparation of the microparticles. Characterisation studies to establish encapsulation efficiency, in vitro release, shape, size and morphology of the microparticles were undertaken. The microparticles produced were in the micrometre size range, with an encapsulation efficiency >75% for both hydrochlorothiazide and captopril. The microparticulate technology is able to offer potential resolution to the half-life mediated dosing frequency of captopril as sustained release of the molecule was observed over a 12-h period. The release of hydrochlorothiazide of >80% suggests an improvement in solubility limited dissolution.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Formulation and Characterisation of a Combination Captopril and Hydrochlorothiazide Microparticulate Dosage Form

2020

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Mini-Tablets: A Valid Strategy to Combine Efficacy and Safety in Pediatrics

et al. 2022

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In the treatment of pediatric diseases, mass-produced dosage forms are often not suitable for children. Commercially available medicines are commonly manipulated and mixed with food by caregivers at home, or extemporaneous medications are routinely compounded in the hospital pharmacies to treat hospitalized children. Despite considerable efforts by regulatory agencies, the pediatric population is still exposed to questionable and potentially harmful practices. When designing medicines for children, the ability to fine-tune the dosage while ensuring the safety of the ingredients is of paramount importance. For these purposes solid formulations may represent a valid alternative to liquid formulations for their simpler formula and more stability, and, to overcome the problem of swelling ability, mini-tablets could be a practicable option. This review deals with the different approaches that may be applied to develop mini-tablets intended for pediatrics with a focus on the safety of excipients. Alongside the conventional method of compression, 3D printing appeared particularly appealing, as it allows to reduce the number of ingredients and to avoid both the mixing of powders and intermediate steps such as granulation. Therefore, this technique could be well adaptable to the daily galenic preparations of a hospital pharmacy, thus leading to a reduction of the common practice of off-label preparations.

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Mini Tablets: A Short Review-Revision

Cited by 2 publications

References 51 publications

Formulation and Characterisation of a Combination Captopril and Hydrochlorothiazide Microparticulate Dosage Form

Formulation and Characterisation of a Combination Captopril and Hydrochlorothiazide Microparticulate Dosage Form

Mini-Tablets: A Valid Strategy to Combine Efficacy and Safety in Pediatrics

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