Miniaturized Multiplex Electrochemical Biosensor in Clinical Bioanalysis

doi:10.4172/1948-593x.1000e122

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…Multiplexed assays allow for measuring multiple biomarkers or chemical species in a single sample, providing comprehensive information for disease diagnosis, drug screening, and environmental monitoring. Integrating multiplexed assays with LoC devices will streamline analytical workflows and reduce the overall assay time, improving efficiency and throughput [89,90].…”

Section: Future Perspectivesmentioning

confidence: 99%

Electrochemical Readout in Lab-On-Chip Platforms: Overview of State of the Art and Future Perspectives

Rodrigues

2023

PoS

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Lab-on-chip (LoC) platforms are disruptive technologies in analytical chemistry and bioengineering and are known to enable miniaturised and sensitive analysis of complex biological and chemical samples. Electrochemical detection became one of the most explored among several readout methods, hence its versatility, robustness, straightforward execution, sensitivity, and portability. Therefore, this brief review critically examines the principles, applications, and prospects of electrochemical detection in LoC technologies, highlighting its significance in advancing various fields, including clinical diagnostics, environmental monitoring, and drug discovery.

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Section: Future Perspectivesmentioning

confidence: 99%

Electrochemical Readout in Lab-On-Chip Platforms: Overview of State of the Art and Future Perspectives

Rodrigues

2023

PoS

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“…In electrochemical biosensors, electrodes play an essential role as the transducer (Li et al, 2017;Mahato, Kumar, et al, 2018) and are also used as a platform for the immobilization of the biorecognition element (Cho et al, 2020). They provide real-time measurements, are less susceptible to interference, and can be scaled down, paving the way for portable and cost-effective lab on a chip multiplex diagnosis (Chandra, 2013b;Li et al, 2017). Since the first electrochemical biosensor was developed by Clark et al in 1962 for glucose monitoring (Clark & Lyons, 2006), several new biosensors have been re- the piezoelectric (Sawant, 2017).…”

Section: Application Of Silk Biomaterials In Biosensorsmentioning

confidence: 99%

Nano‐bio‐engineered silk matrix based devices for molecular bioanalysis

Sammi

Divya

Mahapatra

et al. 2022

Biotech & Bioengineering

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Silk is a fibrous protein, has been a part of human lives for centuries, and was used as suture and textile material. Silk is mainly produced by the members of certain arthropods such as spiders, butterflies, mites, and moths. However, recent technological advances have revolutionized silk as a biomaterial for various applications ranging from heat sensors to robust fibers. The biocompatibility, mechanical resilience, and biodegradability of the material make it a suitable candidate for biomaterials. Silk can also be easily converted into several morphological forms, including fibers, films, sponges, and hydrogels. Provided these abilities, silk have received excellent traction from scientists worldwide for various developments, one of them being its use as a bio-sensor. The diversity of silk materials offers various options, giving scientists the freedom to choose from and personalize them as per their needs. In this review, we foremost look upon the composition, production, properties, and various morphologies of silk. The numerous applications of silk and its derivatives for fabricating biosensors to detect small molecules, macromolecules, and cells have been explored comprehensively. Also, the data from various globally developed sensors using silk have been described into organized tables for each category of molecules, along with their important analytical details.

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“…Great sensitivity, mobility, and quick reaction time make electrochemical sensors (EC) an appealing platform for analytical studies [52][53][54]. Because of advantages such as compactness [55] and low detection limits [56], electrochemical methods have been prolonged and widely exploited to construct sensors aimed at the direct realtime monitoring of important biomarkers in the human body [57]. These characteristics also make electrochemical sensors suitable for wearable devices requiring high flexibility and endurance.…”

Section: Electrochemicalmentioning

confidence: 99%

Engineering Design, Implementation, and Sensing Mechanisms of Wearable Bioelectronic Sensors in Clinical Settings

et al. 2022

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Wearable sensing devices have transformed the hourly analysis of events such as body signals and environmental risks into real‐time monitoring in minutes or seconds. Wearable sensors have facilitated the ability to obtain useful data by monitoring the physiological parameters and activities of an aided and a healthy individual. Wearable devices employ detectable biomarkers in the human body, such as in tears, saliva, interstitial fluid, sweat, and so on. These can deliver relevant information on human health, online activity monitoring, and therapeutic treatments. This section outlines the significance of sample types and associated biomarkers as indicators in the development and manufacturing of wearable biosensors. We have emphasized the most recent advances of wearables based on skin‐like and textile, giving attention to personalized health monitoring to record signals of motion and physiological and body fluid investigation. Furthermore, this review categorizes wearable biosensors based on the sensing mechanism, electrochemical, optical, and mechanical. Additionally, the recent wearables related to the detection of the newly havoc‐causing pandemic, COVID‐19, and the future perspective for the development of much more advanced and potent wearable biosensors have been highlighted. The final section highlights unmet difficulties and gaps in wearable sensors in personalized therapy.

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Miniaturized Multiplex Electrochemical Biosensor in Clinical Bioanalysis

Cited by 4 publications

References 26 publications

Electrochemical Readout in Lab-On-Chip Platforms: Overview of State of the Art and Future Perspectives

Electrochemical Readout in Lab-On-Chip Platforms: Overview of State of the Art and Future Perspectives

Nano‐bio‐engineered silk matrix based devices for molecular bioanalysis

Engineering Design, Implementation, and Sensing Mechanisms of Wearable Bioelectronic Sensors in Clinical Settings

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