Miniaturized neural implants for localized and controllable drug delivery in the brain

Zhao, Xiaotong; Deng, Maosen; Wang, Jun; Liu, Bin; Dong, Yue; Li, Zhe

doi:10.1039/d3tb00728f

Cited by 4 publications

(1 citation statement)

References 130 publications

(240 reference statements)

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“…However, preventing the entry of toxins or pathogens into the CNS also markedly limits the brain uptake of many therapeutic and diagnostic compounds (Ceña and Játiva, 2018). The BBB frequently impedes the effective treatment of neurological disorders by preventing nearly all large-molecule medications and more than 98% of small-molecule medications from adequately penetrating the brain parenchyma (Zhao et al, 2023). While significant progress has been made in recent years, there are still major challenges in achieving controllable drug delivery to…”

Section: Pdanps Increase Bbb Penetrationmentioning

confidence: 99%

Advances in the study of polydopamine nanotechnology in central nervous system disorders

Ren,

Xiao,

et al. 2024

Front. Mater.

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Disorders of the central nervous system (CNS) constitute a significant global health concern at the moment. Most CNS disorders are characterized by severe neuronal damage with excessive production of reactive oxygen species, which induces high levels of oxidative stress and intense inflammatory responses in the affected tissues, thus aggravating disease pathology. Notably, the blood–brain barrier makes it difficult to deliver many drugs and biologics to the CNS, which creates great difficulties in the diagnosis and treatment of CNS disorders. Recent research on polydopamine nanotechnology has led to the discovery of many promising properties; it shows strong scavenging ability for reactive oxygen species, prevents activation of pro-inflammatory microglia, and its repair function can reduce brain damage and protect neurons. Moreover, polydopamine nanotechnology can improve the blood–brain barrier permeability of biologics and reduce their neurotoxicity. It is therefore a promising candidate in the treatment of CNS disorders associated with oxidative stress. In the present paper, we review the functionality of polydopamine nanotechnology as well as the potential and recent advances of polydopamine-based nanosystems in the diagnosis and treatment of various CNS disorders, including Alzheimer’s disease, Parkinson’s disease, stroke, spinal cord injury, and glioma. Finally, we predict how polydopamine nanoparticles may guide future therapeutic strategies to address CNS disorders such as epilepsy, which currently have no cure.

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Section: Pdanps Increase Bbb Penetrationmentioning

confidence: 99%

Advances in the study of polydopamine nanotechnology in central nervous system disorders

Ren,

Xiao,

et al. 2024

Front. Mater.

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A Hybrid Miniaturized Modular Probe for Minimally Invasive Neural Intervention

Zhao,

Deng,

Guo

et al. 2024

Adv Materials Technologies

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Brain's unique anatomical structure and physiological environment make it difficult to deliver therapeutic agents such as drug or light to a focal volume in brain for disease treatment. Physically targeting a fine structure in brain with a micro‐neural probe is an effective solution. Here, we present a hybrid miniaturized neural probe designed with micro‐fluidic channel(s) for drug delivery, micro‐electrode(s) for neural sensing and an optical fiber for optical‐related treatment. These functional components are integrated in a micro‐cannula (diameter <300 µm) with modular design and fabrication properties which can be conveniently adjusted for diverse applications. In vitro and in vivo tests confirm that this probe can precisely deliver drug to a focal volume in brain bypassing the blood brain barrier, and on‐site neural sensing can be achieved with the integrated neural electrode. Leveraging near infrared light’s scattering properties in brain, we demonstrate in vivo with rat glioblastoma model that this hybrid neural probe can be a platform for photothermal treatment of brain tumor. With these merits, the hybrid miniaturized neural probe will be an effective tool with great translational potentials for minimally invasive neural intervention such as drug delivery or combination treatment of brain diseases.

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Rise of implantable drugs: A chronicle of breakthroughs in drug delivery systems

Huanbutta,

Puri,

Sharma

et al. 2024

Saudi Pharmaceutical Journal

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Miniaturized neural implants for localized and controllable drug delivery in the brain

Abstract: Drug delivery in brain has been challenging due to the existence of blood brain barrier, which prevents most drugs from entering the target site in brain. Compared to systematic drug...

Cited by 4 publications

References 130 publications

Advances in the study of polydopamine nanotechnology in central nervous system disorders

Advances in the study of polydopamine nanotechnology in central nervous system disorders

A Hybrid Miniaturized Modular Probe for Minimally Invasive Neural Intervention

Rise of implantable drugs: A chronicle of breakthroughs in drug delivery systems

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