Miniaturized, wireless multi-channel potentiostat platform for wearable sensing and monitoring applications

Alam, Fahmida; Hasan, Muhammad Mahmudul; Siddiquee, Masudur R.; Forouzanfar, Shahrzad; Jalal, Ahmed Hasnain; Pala, Nezih

doi:10.1117/12.2587955

Cited by 5 publications

(2 citation statements)

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“…In 2021, a series of home-built potentiostats have been published [14][15][16][17][18][19][20] among which, regarding the hardware, the MYSTAT project from Irving [18] is probably the most advanced DIY potentiostat to date. Using a PIC16F1459 microcontroller, a 20-bit DAC (DAC1220) and a 22-bit ADC (MCP3550-60) and implementing four current ranges, the device covers remarkable ±200 mA at ±12 V, and is (regarding the operational range) comparable with commercial potentiostats.…”

Section: Introductionmentioning

confidence: 99%

Polarstat: An Arduino Based Potentiostat for Low-Power Electrochemical Applications

Tichter

Gernhard

Vesborg

2023

Preprint

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Section: Introductionmentioning

confidence: 99%

Polarstat: An Arduino Based Potentiostat for Low-Power Electrochemical Applications

Tichter

Gernhard

Vesborg

2023

Preprint

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“…Several researchers have attempted to develop new multichannel potentiostats, but they are neither low-cost enough to be used for low-cost POCT (e.g., for detection of COVID-19 outside of a laboratory) nor sensitive and noise-free enough to meet the high sensitivity needs of ultrasensitive electrochemical biosensors ( Alam et al, 2021 ; Park et al, 2022 ; Ramfos et al, 2013 ; Vinoth et al, 2021 ; Wu et al, 2018 ). The output signals of these readers whether square wave, cyclic voltammetry, or impedance ( Pellitero et al, 2021 ), deals with curve-shaped data that needs further data analysis and curve-fitting approaches to obtain the biosensor data, adding to the complexity of the reader ( Abdullah et al, 2019 ; Bianchi et al, 2019 ; Hoilett et al, 2020 ; Pruna et al, 2018 ; Wu et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

A compact, low-cost, and binary sensing (BiSense) platform for noise-free and self-validated impedimetric detection of COVID-19 infected patients

Salahandish

Jalali

Tabrizi

et al. 2022

Biosensors and Bioelectronics

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Bi-ECDAQ: An electrochemical dual-immuno-biosensor accompanied by a customized bi-potentiostat for clinical detection of SARS-CoV-2 Nucleocapsid proteins

Salahandish

Haghayegh

Ayala-Charca

et al. 2022

Biosensors and Bioelectronics

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Multiplex electrochemical biosensors have been used for eliminating the matrix effect in complex bodily fluids or enabling the detection of two or more bioanalytes, overall resulting in more sensitive assays and accurate diagnostics. Many electrochemical biosensors lack reliable and low-cost multiplexing to meet the requirements of point-of-care detection due to either limited functional biosensors for multi-electrode detection or incompatible readout systems. We developed a new dual electrochemical biosensing unit accompanied by a customized potentiostat to address the unmet need for point-of-care multi-electrode electrochemical biosensing. The two-working electrode system was developed using screen-printing of a carboxyl-rich nanomaterial containing ink, with both working electrodes offering active sites for recognition of bioanalytes. The low-cost bi-potentiostat system (∼$80) was developed and customized specifically to the bi-electrode design and used for rapid, repeatable, and accurate measurement of electrochemical impedance spectroscopy signals from the dual biosensor. This binary electrochemical data acquisition (Bi-ECDAQ) system accurately and selectively detected SARS-CoV-2 Nucleocapsid protein (N-protein) in both spiked samples and clinical nasopharyngeal swab samples of COVID-19 patients within 30 min. The two working electrodes offered the limit of detection of 116 fg/mL and 150 fg/mL, respectively, with the dynamic detection range of 1–10,000 pg/mL and the sensitivity range of 2744–2936 Ω mL/pg.mm 2 for the detection of N-protein. The potentiostat performed comparable or better than commercial Autolab potentiostats while it is significantly lower cost. The open-source Bi-ECDAQ presents a customizable and flexible approach towards addressing the need for rapid and accurate point-of-care electrochemical biosensors for the rapid detection of various diseases.

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Miniaturized, wireless multi-channel potentiostat platform for wearable sensing and monitoring applications

Cited by 5 publications

References 0 publications

Polarstat: An Arduino Based Potentiostat for Low-Power Electrochemical Applications

Polarstat: An Arduino Based Potentiostat for Low-Power Electrochemical Applications

A compact, low-cost, and binary sensing (BiSense) platform for noise-free and self-validated impedimetric detection of COVID-19 infected patients

Bi-ECDAQ: An electrochemical dual-immuno-biosensor accompanied by a customized bi-potentiostat for clinical detection of SARS-CoV-2 Nucleocapsid proteins

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