Minimal Change Disease After Second Dose of Covishield Vaccination

Abstract

Minimal change disease has been associated with different types of vaccinations, and several case reports have associated the development of this disease with COVID vaccinations as well. We present here a case report of a 19-year-old male who developed minimal change nephrotic syndrome following the second dose of Covishield ChAdOx1 nCoV vaccine. He had received his first dose 2 months prior which was uneventful. He developed fever 3 days after second vaccination and 1 week later developed edema, frothuria, and oliguria. His reports showed a 24-h urine protein of 3.7 g per day, serum creatinine of 1.9 mg/dL, and serum albumin of 1.9 g/dL. He underwent a kidney biopsy which showed features consistent with minimal change disease. He was started on prednisolone at 1 mg/kg body weight. He responded well to treatment and attained complete remission after 33 days of steroids with 24-h urine protein of 195 mg/day, serum creatinine of 0.6 mg/dL, and serum albumin of 5.1 g/dL. This case highlights the possibility of occurrence of minimal change disease post Covishield vaccination even after the second dose despite an uneventful first dose.