Minimal change nephrotic syndrome four days after the administration of Pfizer‐BioNTech COVID‐19 vaccine—a new side effect or coincidence?

Abdulgayoom, Mohammed; Albuni, Mhd Kutaiba; Abdelmahmuod, Elabbass; Murshed, Khaled; Eldeeb, Yassir

doi:10.1002/ccr3.5003

Cited by 16 publications

(12 citation statements)

References 9 publications

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“…Two independent reviewers found 133 of these studies irrelevant, while 74 were screened for full text. Out of those, 32 were included in the final analysis (Figure 1) [15,. We removed 12 studies because the study designs were incorrect, 11 because they were related to the wrong patient population, and eight because they did not meet the quality assessment requirements.…”

Section: Resultsmentioning

confidence: 99%

“…The most common side effects of the COVID-19 vaccines include pain, swelling, and redness in the arm where the vaccine is injected, as well as tiredness, muscle pain, headache, fever, chills, and nausea. In addition, less common severe side effects are starting to be recognized, such as nephrotic syndrome, a clinical entity characterized by proteinuria, hypoalbuminemia, edema, and hyperlipidemia, among other complications [12,13,15,16]. This systematic review presents several cases of nephrotic syndrome that presented post-COVID-19 infection or vaccination.…”

Section: Introductionmentioning

confidence: 99%

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Nephrotic Syndrome in Adult Patients With COVID-19 Infection or Post COVID-19 Vaccine: A Systematic Review

Cancarevic¹,

Nassar²,

Medina³

et al. 2022

Cureus

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Nephrotic syndrome is a condition characterized by damage to podocytes that results in significant proteinuria, edema, hyperlipidemia, and hypercoagulability. Infections and malignancies are frequently associated with nephrotic syndrome. The COVID-19 virus has been associated with several atypical presentations of upper respiratory infections and acute kidney injury. Considering that COVID-19 causes systemic inflammatory changes, it seems plausible that it may also lead to nephrotic syndrome. This study aimed to investigate if an association between COVID-19 and the different types of nephrotic syndromes exists. Data were extracted into a spreadsheet. Statistical analysis was performed using Statistical Package for Social Sciences (SPSS, IBM Corp., Armonk, NY, USA).We performed a systematic search of PubMed/Medline and Embase databases using both medical subject headings (MeSH) and regular keywords associated with COVID-19 and nephrotic syndrome, including different types of nephrotic syndromes. The search was performed on 17th December 2021. We included case reports and case series about adult patients who developed findings suggestive of nephrotic syndrome shortly after infection or vaccination. We excluded cases involving children, pregnant women, articles written in languages other than English, and those that were not retrievable. The relevance and quality of identified articles were assessed.We included 32 articles in the study, primarily case reports and case series. In our study, COVID-19 and the COVID-19 vaccine have been associated with the development of nephrotic syndrome, primarily a collapsing form of focal segmental glomerulosclerosis, although other forms have been observed as well. There was little consistency in patient histories, clinical presentations, clinical courses, or treatment regimens, although it appeared that most cases eventually resolved. More cases need to be reported and analyzed before more definitive conclusions can be reached.In conclusion, nephrotic syndrome is a possible complication of both COVID-19 infection and the COVD-19 vaccine and should be considered in patients exhibiting sudden onset edemas or deterioration in kidney function. While the majority of cases respond to standard treatment, clearer guidelines will need to be developed once more data is available.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nephrotic Syndrome in Adult Patients With COVID-19 Infection or Post COVID-19 Vaccine: A Systematic Review

Cancarevic¹,

Nassar²,

Medina³

et al. 2022

Cureus

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“…Relatos de casos incluídos mostram diversas reações adversas graves, sendo elas; renais, como síndrome nefrótica e lesão renal (Abdulgayoom et al 2021;Mira et al 2021); reações dermatológicas, como a síndrome de Sweet (Baffa et al…”

Section: Vacina Sinopharmunclassified

Reações adversas pós-vacinação por COVID-19: uma revisão integrativa

Correa¹,

Pereira²,

Luz

et al. 2022

RSD

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Objetivo: Identificar na literatura as principais reações adversas das vacinas contra o COVID-19. Metodologia: Revisão integrativa, conduzida nas estratégias de busca Biblioteca Virtual em Saúde (BVS), Scopus (Elsevier) e Embase. Por meio da seguinte questão de pesquisa: “Quais reações adversas foram evidenciadas na literatura em pacientes vacinados por COVID-19?”. Utilizou-se o software RAYYAN® para importar os dados. Resultados: Identificou-se 1.816 estudos, destes, 57 contemplaram a revisão. Os resultados foram sintetizados em forma de tabela e verificou-se diversas reações classificadas em reações locais, sistêmicas e graves, constatou-se a maior incidência de reações adversas no sexo feminino e as manifestações foram imediatas a tardias. Conclusão: Foi evidenciado que a maioria das reações adversas pós-vacinação por COVID-19 foram locais, imediatas e autolimitadas. O enfermeiro deve promover ações para prevenir e identificar reações adversas pós vacinais.

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“…The most promising strategy for containing the COVID-19 pandemic is the development of vaccines to prevent SARS-CoV-2 infection. At present, COVID-19 vaccinations are widely accessible across the world [ 4 ]. The most common side effects of COVID-19 immunization are a local response at the injection site, followed by non-specific upper respiratory tract symptoms.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 Vaccine-Induced Cerebral Sinus Thrombosis: Coincidence vs. Cause?

Fadul¹,

Abdalla²,

Abdelmahmuod³

et al. 2022

Cureus

Self Cite

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Patients who were vaccinated against COVID-19 have experienced thrombosis-thrombocytopenia syndrome and cerebral venous sinus thrombosis (CVST). It is important to be aware of this potential side effect of the vaccine and to be able to recognize early clinical symptoms and signs of CVST.In this paper, we present two cases of COVID-19 vaccination-related CVST. The patients who suffered headaches and seizures were found to have CVST, which was treated with anticoagulation.

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Minimal change nephrotic syndrome four days after the administration of Pfizer‐BioNTech COVID‐19 vaccine—a new side effect or coincidence?

Abstract: The association between the COVID vaccine and MCD is temporal and by exclusion, and it is not fully established, but it should be considered in postvvaccine MCD.

Cited by 16 publications

References 9 publications

Nephrotic Syndrome in Adult Patients With COVID-19 Infection or Post COVID-19 Vaccine: A Systematic Review

Nephrotic Syndrome in Adult Patients With COVID-19 Infection or Post COVID-19 Vaccine: A Systematic Review

Reações adversas pós-vacinação por COVID-19: uma revisão integrativa

COVID-19 Vaccine-Induced Cerebral Sinus Thrombosis: Coincidence vs. Cause?

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