Minimally invasive electroceutical catheter for endoluminal defect sealing

Abstract

Surgical repair of lumen defects is associated with periprocedural morbidity and mortality. Endovascular repair with tissue adhesives may reduce host tissue damage, but current bioadhesive designs do not support minimally invasive deployment. Voltage-activated tissue adhesives offer a new strategy for endoluminal repair. To facilitate the clinical translation of voltage-activated adhesives, an electroceutical patch (ePATCH) paired with a minimally invasive catheter with retractable electrodes (CATRE) is challenged against the repair of in vivo and ex vivo lumen defects. The ePATCH/CATRE platform demonstrates the sealing of lumen defects up to 2 millimeters in diameter on wet tissue substrates. Water-tight seals are flexible and resilient, withstanding over 20,000 physiological relevant stress/strain cycles. No disruption to electrical signals was observed when the ePATCH was electrically activated on the beating heart. The ePATCH/CATRE platform has diverse potential applications ranging from endovascular treatment of pseudo-aneurysms/fistulas to bioelectrodes toward electrophysiological mapping.

Electronically optimized diazirine-based polymer crosslinkers

“…15 Polymeric analogues ( e.g. 7 ), created by adding electrophilic diazirine reagents to nucleophilic polymer supports, have also been extensively explored for biological wound healing applications 16,17 and as primers for fibre-reinforced polymer composites 18 and enzyme–polymer assemblies. 19 Diazirine reagents can also add functionality to commodity polymers; 20 for example porphyrin conjugate 8 can be used to generate antiviral coatings on woven polypropylene filter material.…”

Decellularization Following Fixation of Explanted Aortic Valves as a Strategy for Preserving Native Mechanical Properties and Function

“…Before adaptation of this work for any in vivo or tissue engineering application, detailed characterization on cell removal and toxicity is required; 4) preliminary hydrodynamic testing use water which does not mimic the density and viscosity of blood. A monoethylene glycol-based blood-mimicking fluid as described in our previous work ( Singh et al, 2021 ) could improve the hydrodynamic accuracy; 5) since the valves were manually sutured to an adaptor to align them normal to the flow circuit, the natural annulus size and tension applied to the leaflets may have been altered, potentially leading to variability in the normalized orifice area; 6) preliminary hydrodynamic testing does not include the fatigue performance of the valves under pulsatile physiological loading and is part of our future work.…”

Self-folding soft-robotic chains with reconfigurable shapes and functionalities

“…We are currently witnessing a trend in combining flexible electronics with MIS tools [45][46][47][48] . Electronic components can be seamlessly integrated into small surgical tools for sensing 45 , drug delivery 46 , and endothelial sealing 48 .…”