Minimally invasive spine surgery for degenerative spine disease and deformity correction: a literature review

Lykissas, Marios G.; Giannoulis, Dionysios

doi:10.21037/atm.2018.03.18

Cited by 14 publications

(9 citation statements)

References 48 publications

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“…During the last 30 years there has been a significant change in attitude to treating older patients for severe medical conditions, e.g. in cardiology, cancer, and degenerative spine conditions [52][53][54][55]. Increased knowledge and improvements during the last decades in anaesthesiology, intensive care medicine, neurosurgery, advanced surgical techniques, and rehabilitation give us the opportunity to push the previous limits of TBI treatment [56][57][58][59].…”

Section: Self-fulfilling Prophecy?mentioning

confidence: 99%

Traumatic brain injury—the effects of patient age on treatment intensity and mortality

et al. 2020

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Background Ageing is associated with worse treatment outcome after traumatic brain injury (TBI). This association may lead to a self-fulfilling prophecy that affects treatment efficacy. The aim of the current study was to evaluate the role of treatment bias in patient outcomes by studying the intensity of diagnostic procedures, treatment, and overall 30-day mortality in different age groups of patients with TBI. Methods Included in this study was consecutively admitted patients with TBI, aged ≥ 15 years, with a cerebral CT showing intracranial signs of trauma, during the time-period between 2015–2018. Data were extracted from our prospective quality control registry for admitted TBI patients. As a measure of management intensity in different age groups, we made a composite score, where placement of intracranial pressure monitor, ventilator treatment, and evacuation of intracranial mass lesion each gave one point. Uni- and multivariate survival analyses were performed using logistic multinomial regression. Results A total of 1,571 patients with TBI fulfilled the inclusion criteria. The median age was 58 years (range 15–98), 70% were men, and 39% were ≥ 65 years. Head injury severity was mild in 706 patients (45%), moderate in 437 (28%), and severe in 428 (27%). Increasing age was associated with less management intensity, as measured using the composite score, irrespective of head injury severity. Multivariate analyses showed that the following parameters had a significant association with an increased risk of death within 30 days of trauma: increasing age, severe comorbidities, severe TBI, Rotterdam CT-score ≥ 3, and low management intensity. Conclusion The present study indicates that the management intensity of hospitalised patients with TBI decreased with advanced age and that low management intensity was associated with an increased risk of 30-day mortality. This suggests that the high mortality among elderly TBI patients may have an element of treatment bias and could in the future be limited with a more aggressive management regime.

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Section: Self-fulfilling Prophecy?mentioning

confidence: 99%

Traumatic brain injury—the effects of patient age on treatment intensity and mortality

et al. 2020

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“…During the last 30 years there has been a signi cant change in attitude to treating older patients for severe medical conditions, e.g. in cardiology, cancer, and degenerative spine conditions (52)(53)(54)(55). Increased knowledge and improvements during the last decades in anaesthesiology, intensive care medicine, neurosurgery, advanced surgical techniques, and rehabilitation give us the opportunity to push the previous limits of TBI treatment (56)(57)(58)(59).…”

Section: Age and Mortalitymentioning

confidence: 99%

Traumatic brain injury - the effects of patient age on treatment intensity and mortality

Skaansar

Tverdal

Rønning³

et al. 2020

Preprint

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Background Ageing is associated with worse treatment outcome after traumatic brain injury (TBI). This association may lead to a self-fulfilling prophecy that affects treatment efficacy. The aim of the current study was to evaluate the role of treatment bias in patient outcomes by studying the intensity of diagnostic procedures, treatment, and overall 30-day mortality in different age groups of patients with TBI. Methods Included in this study was consecutively admitted patients with TBI, aged ≥ 15 years, with a cerebral CT showing intracranial signs of trauma, during the time-period between 2015–2018. Data were extracted from our prospective quality control registry for admitted TBI patients. As a measure of management intensity in different age groups, we made a composite score, where use of advanced TBI imaging, placement of intracranial pressure monitor, ventilator treatment, and evacuation of intracranial mass lesion each gave one point. Uni- and multivariate survival analyses were performed using logistic multinomial regression. Results A total of 1,571 patients with TBI fulfilled the inclusion criteria. The median age was 58 years (range 15–98), 70% were men, and 39% were ≥ 65 years. Head injury severity was mild in 706 patients (45%), moderate in 437 (28%), and severe in 428 (27%). Increasing age was associated with less management intensity, as measured using the composite score, irrespective of head injury severity. Multivariate analyses showed that the following parameters had a significant association with an increased risk of death within 30 days of trauma: increasing age, moderate/severe TBI, Rotterdam CT-score ≥ 4, and low management intensity (composite score ≤ 3). Conclusion The present study indicates that the management intensity of hospitalised patients with TBI decreased with advanced age and that low management intensity was associated with an increased risk of 30-day mortality. This suggests that the high mortality among elderly TBI patients may have an element of treatment bias and could in the future be limited with a more aggressive management regime.

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Section: Biodegradability and Stability Of Bpmentioning

confidence: 99%

“…Minimal invasion is one of the key points to evaluate the efficacy of repair. From a clinical perspective, injectable materials can simplify surgeons’ operational difficulty, reduce the risk of infection and scar formation, reduce treatment costs, and improve patient comfort [ 178 , 179 ]. Microspheres may be the best minimally invasive treatment [ 180 , 181 ].…”

Section: Application Of Bp-based Microspheres In Bone Regenerationmentioning

confidence: 99%

Black phosphorus-based 2D materials for bone therapy

Cheng

Cai

Zhao

et al. 2020

Bioactive Materials

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Since their discovery, Black Phosphorus (BP)-based nanomaterials have received extensive attentions in the fields of electromechanics, optics and biomedicine, due to their remarkable properties and excellent biocompatibility. The most essential feature of BP is that it is composed of a single phosphorus element, which has a high degree of homology with the inorganic components of natural bone, therefore it has a full advantage in the treatment of bone defects. This review will first introduce the source, physicochemical properties, and degradation products of BP, then introduce the remodeling process of bone, and comprehensively summarize the progress of BP-based materials for bone therapy in the form of hydrogels, polymer membranes, microspheres, and three-dimensional (3D) printed scaffolds. Finally, we discuss the challenges and prospects of BP-based implant materials in bone immune regulation and outlook the future clinical application.

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Minimally invasive spine surgery for degenerative spine disease and deformity correction: a literature review

Cited by 14 publications

References 48 publications

Traumatic brain injury—the effects of patient age on treatment intensity and mortality

Traumatic brain injury—the effects of patient age on treatment intensity and mortality

Traumatic brain injury - the effects of patient age on treatment intensity and mortality

Black phosphorus-based 2D materials for bone therapy

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