“…Currently, there are various methods to improve glabellar lines, such as cosmetics, skin fillers, laser therapy, radiofrequency therapy, etc., but these methods have certain limitations and side effects. 2,3 For example, cosmetics can only temporarily cover glabellar lines, but cannot solve the problem fundamentally 4 ; skin fillers may cause allergic reactions, infections, or unnatural facial contours 5 ; laser therapy and radiofrequency therapy may cause skin damage, pigmentation, or pain. 6 Therefore, it is urgently needed to find a safe, effective, lasting and natural method to improve glabellar lines.…”