Minimally invasive versus open radical cystectomy for bladder cancer: A systematic review and meta-analysis

H, Shi; Li, Jiangsong; Li, Kui; Yang, Xiaobo; Zhu, Zhi‐Jun; Tian, Daxue

doi:10.1177/0300060519864806

Cited by 13 publications

(4 citation statements)

References 28 publications

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“…Several meta-analyses have been published in the last two years that aggregate large amounts of data to compare iRARC, eRARC, and ORC [35–46]; they report similar findings as above. Generally, when comparing RARC (inclusive of both intracorporeal and extracorporeal technique) and ORC they report equivalent oncological outcomes and an advantage in lower EBL, lower transfusion rates, shorter length of stay, and quicker return to regular diet.…”

Section: Intracorporeal Urinary Diversionsupporting

confidence: 57%

Update on robotic cystectomy

Grauer

Wiklund

2021

Current Opinion in Urology

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Purpose of reviewThis article aims to discuss recently published (2019–2021) studies on robot-assisted radical cystectomy (RARC) with attention to evidence comparing intracorporeal (ICUD) and extracorporeal urinary diversion (ECUD) in terms of intraoperative and perioperative metrics.Recent findingsRARC produces equivalent oncological outcomes compared to open radical cystectomy (ORC). The benefits of RARC are most pronounced perioperatively. ICUD has been increasingly used at centers of excellence as it reduces intestinal exposure, which may incrementally minimize morbidity compared to ECUD or ORC. As the learning curve for ICUD diversion has flattened, retrospective analyses have emerged that suggest this technique may hold benefit over both ORC and RARC with ECUD, though current data is conflicting, and a randomized controlled study is forthcoming.SummaryORC is the current ‘gold standard’ management for muscle-invasive bladder cancer. Based on the premise of the minimization of perioperative morbidity, the development of RARC, most recently with ICUD, seeks to improve patient outcomes. Despite a protracted learning curve, many expert bladder cancer centers have adopted an intracorporeal approach. As more centers adopt, refine, and climb the learning curve for ICUD, a clearer insight of its effect on morbidity will be revealed—informing further adoption of the technique.

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Section: Intracorporeal Urinary Diversionsupporting

confidence: 57%

Update on robotic cystectomy

Grauer

Wiklund

2021

Current Opinion in Urology

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“…Shi et al . [ 35 ] conducted a meta-analysis solely of RCTs comparing minimally invasive radical cystectomy (6 RCTs comparing RARC with ORC and 3 RCTs comparing LRC with ORC) with ORC. The authors found that both RARC and LRC offered significant benefits over ORC in terms of EBL, transfusion rate, time to regular diet and LOS.…”

Section: Resultsmentioning

confidence: 99%

Role of laparoscopy in the era of robotic surgery in urology in developing countries

Bansal

Chaturvedi

Maheshwari

et al. 2021

Indian Journal of Urology

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With the rapid expansion of robotic platforms in urology, there is an urgent and unmet need to review its cost and benefits in comparison to the traditional laparoscopy, especially in reference to a developing country. A nonsystematic review of the literature was conducted to compare the outcomes of pure laparoscopic and robot-assisted urologic procedures. Available literature over the past 30 years was reviewed. Robot-assisted surgery and laparoscopy were found to have similar outcomes in the areas of radical prostatectomy, partial and radical nephrectomy, radical cystectomy, retroperitoneal lymph node (LN) dissection, inguinal LN dissection, donor nephrectomy, and kidney transplantation. Robot-assisted surgery was found to be significantly costlier than pure laparoscopy. In the absence of a clear advantage of robot-assisted surgery over pure laparoscopy, lack of widespread availability and the currently prohibitive cost of robotic technology, laparoscopic urological surgery has a definite role in the developing world.

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“…When diagnosing and evaluating the efficacy, cystoscopy and tissue biopsy are still the gold standards for diagnosis. However, cystoscopy is the most invasive examination, and frequent reexaminations will seriously affect the patient's quality of life [16]. Pathological features such as tumor stage, histological grade, and lymph node metastasis are auxiliary methods [17].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Ki-67 or Profilin-1 Expression Levels, Clinicopathological Characteristics and Postoperative Prognosis in Patients with Bladder Cancer

2024

Ann Ital Chir

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Background: Bladder cancer is the most common malignancy of the urinary system, and the search for new and reliable biomarkers has important clinical significance for the personalized treatment of bladder cancer. This study aims to explore the correlation between nuclear proliferation antigen (Ki-67) or Profilin-1 (PFN1) levels, clinicopathological characteristics, and postoperative prognosis in patients with bladder cancer. Methods: Patients with bladder cancer who underwent transurethral resection of bladder cancer tumor in The Fourth Affiliated Hospital of Soochow University, hospital from January 2019 to January 2021 were selected as the study group (n = 60), and patients with benign lesions of bladder cancer during the same period were selected as the control group (n = 60). The expression of Ki-67 and PFN1 in tumor and bladder tissues of the two groups was analyzed. Ki-67 recorded the patient's pathological parameters and calculated the patient's postoperative prognosis. The correlation between Ki-67 and PFN1 expression levels, pathological parameters, and postoperative prognosis was analyzed. Results: The positive expression rates of Ki-67 and PFN1 in the study group were 63.33% and 73.33%, respectively, which were significantly higher than the positive expression rates in the control group (χ2 = 14.803, 17.757, p < 0.001). The positive expression rates of Ki-67 and PFN1 were related to histological grade, clinical stage, infiltration, and lymph node metastasis, and the differences were statistically significant (p < 0.05). Bladder cancer patients with non muscle-invasive bladder cancer (NMIBC), high-grade histological grade, Ta~T1 clinical stage, invasive, and lymph node metastasis have a higher Ki-67 positive expression rate than bladder cancer patients with muscle-invasive bladder cancer (MIBC), low-grade histological grade, T2~T4, non-invasive, and no lymph node metastasis. The high expression level of Ki-67 has little relationship with gender, age, tumor diameter, and vascular invasion (p > 0.05). The survival time and three-year survival rate of the Ki-67 positive expression group were significantly lower than those of the Ki-67 negative expression group (p < 0.05). The survival time and three-year survival rate of the PFN1 positive expression group were significantly lower than those of the PFN1 negative expression group (p < 0.05). Conclusion: The positive expression rates of Ki-67 and PFN1 in bladder tumor tissue are significantly higher than those in bladder tissue, and pathological pattern, histological grade, clinical stage, infiltration, and lymph node metastasis are related to the positive expression rates of Ki-67 and PFN1, and different genders, ages, tumors diameter and vascular invasion are not related to the positive expression rates of Ki-67 and PFN1. The survival time and three-year survival rates of bladder cancer patients with Ki-67 positive and PFN1 positive expression are shorter.

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Minimally invasive versus open radical cystectomy for bladder cancer: A systematic review and meta-analysis

Cited by 13 publications

References 28 publications

Update on robotic cystectomy

Update on robotic cystectomy

Role of laparoscopy in the era of robotic surgery in urology in developing countries

Correlation between Ki-67 or Profilin-1 Expression Levels, Clinicopathological Characteristics and Postoperative Prognosis in Patients with Bladder Cancer

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