Minimally invasive wireless motility capsule to study canine gastrointestinal motility and pH

Warrit, Kanawee; Boscán, Pedro; Ferguson, Leah; Bradley, Allison; Dowers, Kristy L.; Rao, Sangeeta; Twedt, David C.

doi:10.1016/j.tvjl.2017.08.005

Cited by 18 publications

(29 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…GET measured in this study fell within the same range of GETs reported in a different population of dogs by others using the same type of WMC device . Boillat et al .…”

Section: Discussionsupporting

confidence: 89%

“…They were all fed the same diet before and after the laparoscopic gastropexy and during the evaluation of stomach motility. Dogs were immediately returned to their home environments after administration of the WMC before and after laparoscopic gastropexy to minimise the effect of stress of hospitalisation on gastric motility, as stress has been shown to reduce gastric activity and prolong GET . Warrit et al evaluated GET in dogs in their home environment and in dogs kept hospitalised, and there was a significant increase in the GET of hospitalised dogs (median, 71.8 h) compared with dogs in their home environment (median, 17.6 h) .…”

Section: Discussionmentioning

confidence: 99%

“…Dogs were immediately returned to their home environments after administration of the WMC before and after laparoscopic gastropexy to minimise the effect of stress of hospitalisation on gastric motility, as stress has been shown to reduce gastric activity and prolong GET. 26,27 Warrit et al evaluated GET in dogs in their home environment and in dogs kept hospitalised, and there was a significant increase in the GET of hospitalised dogs (median, 71.8 h) compared with dogs in their home environment (median, 17.6 h). 28 We elected to have dogs return for suture removal 3 weeks postoperatively to try to reduce the effects of general anaesthesia on GET, although others showed that GET returned to normal within 56 h following laparoscopic surgery, using the WMC.…”

Section: Discussionmentioning

confidence: 99%

“…GET measured in this study fell within the same range of GETs reported in a different population of dogs by others using the same type of WMC device. 17,18,27,30 Boillat et al 17 validated this particular WMC for evaluating stomach function in dogs by comparing it with nuclear scintigraphy, the current gold standard for measuring GET. They also noted that the WMC measurements exhibited moderate intra-individual variability, which was similar to that with nuclear scintigraphy.…”

Section: Discussionmentioning

confidence: 99%

“…17,18 Lidbury et al in a study assessing the utility of ranitidine for use in healthy adult dogs and its subsequent effect on GET, documented GET between 622 and 1320 min before treatment with ranitidine. 30 Using the same type of WMC, Warrit et al performed two separate studies with a median GET of 20 h in 44 healthy adult dogs 27 and a median GET of 17.6 h in 11 non-hospitalised dogs kept in their individual homes. 28 GET was not significantly affected by prophylactic laparoscopic gastropexy in this study.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Evaluation of gastric motility in nine dogs before and after prophylactic laparoscopic gastropexy: a pilot study

et al. 2019

View full text Add to dashboard Cite

Background The purpose of this study was to evaluate the effect of a prophylactic laparoscopic gastropexy on gastric motility in healthy large‐breed dogs. Methods This was a prospective pilot study with nine healthy client‐owned dogs. Each dog was its own control. Gastric motility was evaluated before and after laparoscopic gastropexy. Dogs were fed a standard diet three weeks before and after surgery. Gastric motility was measured before and 3 weeks after surgery. A wireless motility capsule (WMC) was used to measure gastric pH, intragastric pressure, temperature, frequency of contractions, motility index (MI) and transit time. Non‐parametric statistical analysis was used to compare the paired data. Clients were contacted for follow‐up information 2 years postoperatively. Results Median frequency of gastric contractions was 1.3 (range, 0.6–1.9 contractions/min) before gastropexy and 1.0 (range, 0.3–2.6 contractions/min) after gastropexy (P = 0.820). Median MI was 49.2 (range, 23.7–96.6) before gastropexy and 28.1 (range, 12.2–148.9) after gastropexy (P = 0.652). Median gastric emptying time was 1140 (range, 486–1230 min) before gastropexy and 1110 (range, 306–2610 min) after gastropexy (P = 0.570). During the hour before the WMC passed through the pylorus, median MI was 72.2 (range, 48.2–549.3) before gastropexy and 52.9 (range, 15.20–322.8) after gastropexy (P = 0.734), and frequency of contractions was 1.1 (range, 0.9–4.1 contractions/min) before gastropexy and 1.2 (range, 0.5–3.0 contractions/min) after gastropexy (P = 0.652). Conclusion Motility in the stomach did not change in healthy dogs after prophylactic laparoscopic gastropexy. We conclude that preventive laparoscopic gastropexy does not induce gastroparesis.

show abstract

“…GET measured in this study fell within the same range of GETs reported in a different population of dogs by others using the same type of WMC device . Boillat et al .…”

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of gastric motility in nine dogs before and after prophylactic laparoscopic gastropexy: a pilot study

et al. 2019

View full text Add to dashboard Cite

show abstract

Gastric and Intestinal Motility Disorders

Horowitz¹,

Camilleri²

2019

Blackwell's Five‐Minute Veterinary Consult Clinical Companion

View full text Add to dashboard Cite

Canine Mucosal Artificial Colon: development of a new colonic in vitro model adapted to dog sizes

Deschamps,

Denis,

Humbert

et al. 2024

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

Differences in dog breed sizes are an important determinant of variations in digestive physiology, mainly related to the large intestine. In vitro gut models are increasingly used as alternatives to animal experiments for technical, cost, societal, and regulatory reasons. Up to now, only one in vitro model of the canine colon incorporates the dynamics of different canine gut regions, yet no adaptations exist to reproduce size-related digestive parameters. To address this limitation, we developed a new model of the canine colon, the CANIne Mucosal ARtificial COLon (CANIM-ARCOL), simulating main physiochemical (pH, transit time, anaerobiosis), nutritional (ileal effluent composition), and microbial (lumen and mucus-associated microbiota) parameters of this ecosystem and adapted to three dog sizes (i.e., small under 10 kg, medium 10–30 kg, and large over 30 kg). To validate the new model regarding microbiota composition and activities, in vitro fermentations were performed in bioreactors inoculated with stools from 13 dogs (4 small, 5 medium, and 4 large). After a stabilization period, microbiota profiles clearly clustered depending on dog size. Bacteroidota and Firmicutes abundances were positively correlated with dog size both in vitro and in vivo, while opposite trends were observed for Actinobacteria and Proteobacteria. As observed in vivo, microbial activity also increased with dog size in vitro, as evidenced from gas production, short-chain fatty acids, ammonia, and bile acid dehydroxylation. In line with the 3R regulation, CANIM-ARCOL could be a relevant platform to assess bilateral interactions between food and pharma compounds and gut microbiota, capturing inter-individual or breed variabilities. Key points • CANIM-ARCOL integrates main canine physicochemical and microbial colonic parameters • Gut microbiota associated to different dog sizes is accurately maintained in vitro • The model can help to move toward personalized approach considering dog body weight

show abstract

Minimally invasive wireless motility capsule to study canine gastrointestinal motility and pH

Cited by 18 publications

References 26 publications

Evaluation of gastric motility in nine dogs before and after prophylactic laparoscopic gastropexy: a pilot study

Evaluation of gastric motility in nine dogs before and after prophylactic laparoscopic gastropexy: a pilot study

Gastric and Intestinal Motility Disorders

Canine Mucosal Artificial Colon: development of a new colonic in vitro model adapted to dog sizes

Contact Info

Product

Resources

About