Minimizing Complications from Systemic Glucocorticosteroid Use

Nesbitt, Lee T.

doi:10.1016/s0733-8635(18)30055-x

Cited by 62 publications

(45 citation statements)

References 32 publications

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“…31,32 Steroid medication has proved to be well suited to the treatment of postoperative pain, trismus, and swelling after dental surgical procedures, 21,22 but perioperative corticosteroid use carries potential complications. 23 Adverse effects include myopathy, osteoporosis, peptic ulcer, ocular effects, central nervous system effects, altered distribution of body fat, increased susceptibility to infection, suppression of pituitary and adrenal function, and poor wound healing. 19,23 These effects are most commonly seen with long-term glucocorticosteroid therapy.…”

Section: Discussionmentioning

confidence: 99%

“…23 Adverse effects include myopathy, osteoporosis, peptic ulcer, ocular effects, central nervous system effects, altered distribution of body fat, increased susceptibility to infection, suppression of pituitary and adrenal function, and poor wound healing. 19,23 These effects are most commonly seen with long-term glucocorticosteroid therapy. Topical and systemic glucocorticoids are contraindicated in patients with ocular herpes simplex, primary glaucoma, tuberculosis, or acute psychosis.…”

Section: Discussionmentioning

confidence: 99%

“…Topical and systemic glucocorticoids are contraindicated in patients with ocular herpes simplex, primary glaucoma, tuberculosis, or acute psychosis. 19,23 The adverse effects with the use of glucocorticoids depend on the intensity and duration of medication. 19,23 A single large dose or a short duration of therapy causes fewer adverse effects, and preoperative medication with NSAIDs or steroids has been suggested to have favourable effects.…”

Section: Discussionmentioning

confidence: 99%

“…[9][10][11][12][13][14][15][16][17][18][19][20] Steroids can be prescribed in conjunction with NSAIDs, and the combination of corticosteroids and NSAIDs has proved to be well suited to the treatment of postoperative pain, trismus, and swelling after dental surgical procedures. 21,22 Nevertheless, there are potential complications associated with perioperative corticosteroid use, 23 and standardized dosage and administration methods for steroids during third molar surgery have yet to be established.…”

Section: Introductionmentioning

confidence: 99%

“…19,23 A single large dose or a short duration of steroid therapy causes few adverse effects for most patients, and preoperative medication with NSAIDs or steroids can have favourable effects. [24][25][26][27][28] This study examined the effect of a single administration of a preoperative oral steroid on postoperative symptoms in 462 ª 2010 Australian Dental Association…”

Section: Introductionmentioning

confidence: 99%

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Effect of preoperative prednisolone on clinical postoperative symptoms after surgical extractions of mandibular third molars

Kang

Choi²,

Iy³

et al. 2010

Australian Dental Journal

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Background: This study compared postoperative symptoms in patients treated preoperatively with a single dose of £20 mg oral steroid during third molar surgery. Methods: A total of 450 patients were categorized randomly into three groups containing 150 patients each. Patients were in their second or third decade and had no specific medical history and findings involving infections of the mandibular third molar area. Two groups received preoperative steroids orally one hour before the operation; one group received 10 mg prednisolone and the other received 20 mg. No steroids were administered to the control group. Patients were asked to report by questionnaire any changes in postoperative symptoms, such as pain, facial oedema, or gastrointestinal disorders, and in masticatory disorders, trismus, or swallowing discomfort. They reported daily from days 1 to 6 post-extraction by evaluating their experience over the preceding 24 hours. Results: A single preoperative oral administration of £20 mg prednisolone had no significant effect on postoperative symptoms of pain, facial oedema, or gastrointestinal upset, or on masticatory symptoms, trismus, or swallowing discomfort in mandibular third molar surgery. Conclusions: A single oral dose of £20 mg prednisolone before third molar extraction may not be helpful for the relief of postoperative symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of preoperative prednisolone on clinical postoperative symptoms after surgical extractions of mandibular third molars

Kang

Choi²,

Iy³

et al. 2010

Australian Dental Journal

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Approach to corticosteroid-dependent and corticosteroid-refractory Crohn's disease

Lichtenstein

2001

Inflamm Bowel Dis

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Corticosteroids are considered a drug of choice for the treatment of patients with moderately to severely active Crohn's disease (CD), an inflammatory bowel disease characterized by chronic recurrent flares of disease activity. However, among patients receiving corticosteroid therapy for induction of remission, 20% have corticosteroid-refractory disease and 36% of those with an initial response develop corticosteroid dependency within 1 year. Chronic corticosteroid exposure in patients who are corticosteroid dependent increases the risk for serious drug-related adverse effects. Withdrawal or reduction of corticosteroid therapy without exacerbation of symptoms is therefore recognized as an important goal of treatment. Therapies that have been shown to facilitate "steroid sparing' include the immunomodulators azathioprine/6-mercaptopurine and methotrexate and the antitumor necrosis factor-alpha monoclonal antibody infliximab. In corticosteroid-dependent patients, budesonide may be substituted for conventional corticosteroid therapy without loss of response and with less risk for toxicity, but its long-term efficacy requires further evaluation. A preliminary controlled study suggests that the investigational anti-TNF monoclonal antibody CDP-571 may also be clinically beneficial as a corticosteroid-sparing agent. This review summarizes the clinical evidence that supports consideration of these agents as alternatives in patients with CD who are dependent on, refractory to, or intolerant of conventional corticosteroid therapy.

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Approach to Steroid‐Dependent and Steroid‐Refractory Crohn's Disease

Lichtenstein

2001

J. pediatr. gastroenterol. nutr.

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Minimizing Complications from Systemic Glucocorticosteroid Use

Cited by 62 publications

References 32 publications

Effect of preoperative prednisolone on clinical postoperative symptoms after surgical extractions of mandibular third molars

Effect of preoperative prednisolone on clinical postoperative symptoms after surgical extractions of mandibular third molars

Approach to corticosteroid-dependent and corticosteroid-refractory Crohn's disease

Approach to Steroid‐Dependent and Steroid‐Refractory Crohn's Disease

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