Minimizing the Impact of Time Lag Variability on Accuracy Evaluation of Continuous Glucose Monitoring Systems

Scuffi, Cosimo; Lucarelli, Fausto; Valgimigli, Francesco

doi:10.1177/193229681200600618

Cited by 17 publications

(16 citation statements)

References 37 publications

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“…This indicates that although there is absolutely no error at all in the measurements per se, the time delay has a high impact on the performance characteristics. A related analysis of the effect of time delays on the CGM performance was also presented in Scuffi et al 6 To separate the effects of time delays from that of analytical error, 1 guideline for the evaluation of CGM systems issued by the Clinical and Laboratory Standard Institute (CLSI) 20 suggests procedures to retrospectively remove the time delay from the measurements before evaluating the accuracy. This yields a figure which is closer to the "real" analytical accuracy of the given CGM system.…”

Section: Effect Of Time Delay On Sensor Performancementioning

confidence: 99%

Time Delay of CGM Sensors

Schmelzeisen-Redeker¹,

Schoemaker²,

Kirchsteiger

et al. 2015

J Diabetes Sci Technol

113

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Section: Effect Of Time Delay On Sensor Performancementioning

confidence: 99%

Time Delay of CGM Sensors

Schmelzeisen-Redeker¹,

Schoemaker²,

Kirchsteiger

et al. 2015

J Diabetes Sci Technol

113

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“…In actuality, there is a delay of 5-15 minutes between the blood and interstitial glucose depending on the specific technology but such a lag time does not appear to result in a diminution of the benefits of these devices. 33 Two recent meta-analyses of randomized controlled trials showed that RT-CGM was superior to self-monitoring of blood glucose (SMBG) in reducing A1c by almost 0.4% in both children and adults. 25,34 It should be noted that these meta-analyses include some studies in which the patient's insulin delivery was CSII in some cases effectively making them studies of sensor-augmented pumping (see below).…”

Section: Real-time Continuous Glucose Monitors (Rt-cgm)mentioning

confidence: 99%

The Benefits, Limitations, and Cost-Effectiveness of Advanced Technologies in the Management of Patients With Diabetes Mellitus

Vigersky

2015

J Diabetes Sci Technol

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The New York Times published an article on April 5, 2014, titled "Even Small Medical Advances Can Mean Big Jumps in Bills" by Elizabeth Rosenthal, 1 claiming that diabetes technologies and therapies are overpriced, offer little value, and place an unjust burden on the US health care system. "That captive audience of Type 1 diabetics has spawned lines of high-priced gadgets and disposable accouterments, borrowing business models from technology companies like Apple." This controversial article failed to capture the benefits of technology not only in improving glycemic control as determined by hemoglobin A1c (A1c) but also in mitigating the frequency, severity, and cost of hypoglycemia. The article also did not address the increasing problem and resultant costs of hypoglycemia in patients with type 2 diabetes and how technology might be used to mitigate this as well. 2 In light of Rosenthal's article, it is important to objectively review the literature to answer the following questions: 1. What is the cost of hypoglycemia? 2. What is the evidence that technology can improve A1c and/or reduce the risk of hypoglycemia? 3. What are the limitations in using technology to accomplish this? 4. What is the cost-effectiveness of technology? 5661D STXXX10.

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“…17 A diffúziómodell általában Mesterséges hasnyálmirigy a páciens élettani folyamatait leíró modellbe van beágyazva, de számos példa van arra is, hogy maga a szenzormodell tartalmazza ezt a leírást. 25,26,34 Érdemes megemlíteni, hogy az AP ezen részét egyszerű kompartment modellekkel is sikeresen lehet modellezni. A kompartmentmodellek a kompartmentekkel írják le a test bizonyos egységeit, például folyadéktereit, izmokat, amelyekben általában koncentráció típusú mértékegységekkel reprezentálhatók a modellezés szempontjából fontos anyagok.…”

Section: Cgms Rendszerek Használataunclassified

Mesterséges hasnyálmirigy – A cukorbetegség automatikus kezelése mérnöki megközelítéssel

Kovács¹,

Eigner²,

Czakó³

et al. 2019

Diabetologia Hungarica

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Összefoglalás A közlemény rövid naprakész áttekintést ad a mesterséges hasnyálmirigy (artificial pancreas: AP) felépítésével és működésével kapcsolatban, amelynek segítségével automatizált módon lehet a cukorbetegségben szenvedő betegeket kezelni. Ez az interdiszciplináris megközelítés ötvözi az orvosi tudományokat, a mérnöki irányításelméletet, valamint az egészségügyi mérnöki területeket. A folyamatos glukózmonitorozás, valamint az inzulinpumpák megjelenésének segítségével az AP hatékony megoldást nyújthat a jövőben több millió diabeteses beteg kezelése során. Ezen felül a félautomata AP képes garantálni a páciens megfelelő vércukorszintjét. A jelen dolgozatban bemutatjuk az AP általános működését, valamint ismertetünk néhány praktikus modellezési, valamint szabályozási megoldást is. ■ Kulcsszavak: mesterséges hasnyálmirigy, diabetes mellitus Artificial pancreas-an engineering approach of diabetes treatment Summary: The paper gives a short review on the artificial pancreas (AP), which can be used for automated treatment of diabetic patients. This highly interdisciplinary concept involves beyond medical sciences, control engineering and biomedical engineering knowledge. Having already developed continuous glucose sensor devices and highly performant insulin pumps, the AP can be an efficient solution for millions of people living with diabetes for accurate metabolic conditions management. Furthermore, as a semi-automatic device, AP can guarantee tight blood glucose control. In this paper, we summarize not just the AP concept, but give a short review on the modeling and control solutions as well.

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Minimizing the Impact of Time Lag Variability on Accuracy Evaluation of Continuous Glucose Monitoring Systems

Cited by 17 publications

References 37 publications

Time Delay of CGM Sensors

Time Delay of CGM Sensors

The Benefits, Limitations, and Cost-Effectiveness of Advanced Technologies in the Management of Patients With Diabetes Mellitus

Mesterséges hasnyálmirigy – A cukorbetegség automatikus kezelése mérnöki megközelítéssel

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