Minimum diagnostic criteria for plasmablastic lymphoma of oral/sinonasal region encountered in a tertiary cancer hospital of a developing country

Kane, Shubhada; Khurana, Aditi; Parulkar, Gorakh; Shet, Tanuja; Prabhash, Kumar; Nair, Reena; Gujral, Sumeet

doi:10.1111/j.1600-0714.2008.00673.x

Cited by 46 publications

(38 citation statements)

References 20 publications

(23 reference statements)

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“…14-17 There is a strong male predominance, with a median age of 36 (range 5-86). 15-18 A variant of PBL arising in elderly, HIV-negative patients has also been described, which has a median age at presentation of 68 years, also shows a male predominance, and has a predilection for the nasal cavity. 17 The prognosis of PBL is poor, with most patients dying within a year following diagnosis.…”

Section: Aggressive B-cell Neoplasmsmentioning

confidence: 99%

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Hematolymphoid lesions of the sinonasal tract

Crane

Duffield

2016

Seminars in Diagnostic Pathology

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Summary Various hematolymphoid lesions involve the sinonasal tract, including aggressive B, T, and NK-cell neoplasms; myeloid sarcoma; low grade lymphomas; indolent T-lymphoblastic proliferations; and Rosai-Dorfman disease. Differentiating aggressive lymphomas from non-hematopoietic neoplasms such as poorly differentiated squamous cell carcinoma, olfactory neuroblastoma, or sinonasal undifferentiated carcinoma may pose diagnostic challenges. In addition, the necrosis, vascular damage and inflammatory infiltrates which are associated with some hematolymphoid disorders can result in misdiagnosis as infectious, autoimmune or inflammatory conditions. Here, we review hematolymphoid disorders involving the sinonasal tract including their key clinical and histopathologic features.

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Section: Aggressive B-cell Neoplasmsmentioning

confidence: 99%

“…3, A-C). 18 The tumor cells are characteristically CD138, CD38, and MUM-1 positive, and usually demonstrate light chain restriction. CD79a, CD30 and EMA are also frequently expressed, but the neoplastic cells are negative or only weakly positive for CD45, CD20 and PAX5.…”

Section: Aggressive B-cell Neoplasmsmentioning

confidence: 99%

Hematolymphoid lesions of the sinonasal tract

Crane

Duffield

2016

Seminars in Diagnostic Pathology

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“…Bu lenfomanın özelliği immunohistokimyasal olarak B hücre göstergelerinin (CD20, CD45 gibi) zayıf pozitif veya negatif, buna karşılık plazma hücre göstergelerinin (CD38, CD138, VS38c gibi) ve EBV antijeninin sıklıkla pozitif olmasıdır. 2,4,5,[12][13][14][15][16][17] PBL'nin sıklıkla genç yaşlarda (ortalama 39 yaş), erkek cinsiyette (%79), oral kavitede (%66) görüldüğü ve yine sıklıkla EBV ile ilişkili olduğu (%74) bildirilmiştir. (4) bölge, omentum, testis, Kİ ve santral sinir sistemi (SSS) tutulumları değişik yayınlarda bildirilmiş-tir.…”

Section: Discussionunclassified

Oral Plasmablastic Lymphoma in a Case with HIV Infection

Ural¹,

Kaptan²,

Türker³

et al. 2012

Turkiye Klinikleri J Med Sci

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Ö ÖZ ZE ET T Plazmablastik lenfoma (PBL) nadir görülen bir malignitedir ve en sık HIV (human immunodeficiency virus) ile enfekte olgularda ve yine sıklıkla oral kavitede saptanmaktadır. İlk kez 1997 yılında tanımlanmıştır. Diffüz büyük B-hücreli lenfomanın farklı bir alttipi olarak tarif edilmiştir. Son yıllarda sıklıkla oral kavite dışında da rapor edilmiştir. Gastrointestinal sistem ve deri, oral kavite dışında en sık tutulan organlardır. Plazmablastik lenfoma genellikle tipik B-hücre göstergelerinde (örnek olarak CD20) negatiflik, CD38, CD138 ve VS38c gibi plazma hücre göstergelerinde pozitiflik içeren karekteristik bir immunofenotip gösterir. Biz, bu makalede 44 yaşında, oral kavitede 30x30 mm boyutlarında kitle, akciğer tüberkülozu ve beyinde sol talamik bölgede 18x30 mm boyutlarında kitle lezyonu saptanan HIV ile enfekte bir erkek olgu sunduk. Oral kavitedeki lezyonun histopatolojik incelemesi PBL ile uyumlu idi. Neoplastik hücreler CD20 negatif bulundu. Hematoksilen eozin boyasında çok katlı yassı epitel altında plazmasitoid özellikte, iri eozinofilik nükleuslu, bazıları nükleolus içeren mitoz aktif neoplastik lenfoid infiltrasyon izlendi. Kemik iliği biyopsisinde non-Hodgkin lenfoma (NHL) tutulumu tespit edildi. Olguya HIV enfeksiyonu açısından HAART (Highly active antiretroviral therapy) tedavisi olarak stavudin + lamivudin + lopinavir/ritonavir; akciğer tüberkülozu tedavisi için dörtlü anti-tüberküloz tedavi olarak izoniazid + etambutol + rifampisin/streptomisin + morfoziamid; PBL için kemoterapi olarak siklofosfamid + doksorubisin + onkovin + prednizon (CHOP) ve radyoterapi verildi. Tedaviye rağmen olgu 7,5 ay izlendikten sonra kaybedildi. Erken tanı ve uygun tedavi olguların yaşam sürelerini uzatabileceği için HIV enfekte olguların nadir görülen maligniteler açısından taranmasına dikkati çekmek amacıyla ve ülkemizdeki ilk olgu olması nedeniyle bu olgu bildirilmiştir.A An na ah ht ta ar r K Ke el li im me el le er r: : HIV enfeksiyonları; lenfoma, Aids ile ilişkili; lenfoma, büyük B-hücreli, yaygın A AB BS ST TR RA AC CT T Plasmablastic lymphoma (PBL) is a rarely seen malignant lesion and it is most commonly detected in HIV (Human-immunodeficiency virus)-infected subjects predominantly in the oral cavity. It was first described in 1997. It has been recognized as a distinct entity, as a subtype of diffuse large B-cell lymphoma. Recently, PBL presentation has been reported frequently outside the oral cavity. Gastrointestinal tract and skin were the most commonly involved extra-oral organ systems. Plasmablastic lymphoma usually displays a characteristic immunophenotype that includes negativity for typical B-cell markers (eg, CD20), and positivity for plasma cell markers such as CD38, CD138 and VS38c. In this report, we described a case of PBL in a 44-year-old HIV infected male patient who presented with an expanding 30x30 mm oral lesion, pulmonary tuberculosis and an 18x30 mm cerebral left thalamic lesion. Histopathological evaluation of the lesion in oral cavity was consistent with PBL. The neoplastic c...

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“…Second, PBLs have an unusual immunophenotype that renders them susceptible to pathologic misdiagnosis. PBL is classified as a B cell lymphoma and its cellular morphology resembles immunoblastic diffuse large B-cell lymphoma, yet these tumors fail to consistently and strongly express leukocyte common antigen and the B cell markers CD20 and CD79a [1,4,8]. Diagnosis of PBL requires the use of additional markers to confirm plasmacytic differentiation.…”

Section: Discussionmentioning

confidence: 99%

Plasmablastic Lymphoma Involving the Parotid Gland

Bishop

Westra

2010

Head and Neck Pathol

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Plasmablastic lymphoma is a rare form of nonHodgkin lymphoma. It is strongly associated with HIV infection, although it has been recognized in immunocompetent patients. Plasmablastic lymphoma has a predilection for the oral cavity. Its occurrence in the parotid gland has not been previously described. We report a case of an HIV positive man who developed a rapidly enlarging parotid mass. A core biopsy of the parotid mass was evaluated by routine microscopy, immunohistochemistry, and in situ hybridization. The tumor was comprised of sheets of large cells with abundant cytoplasm, eccentric nuclei and prominent nucleoli. The cells exhibited a plasmacytic immunophenotype including expression for CD38 and CD138. An in situ hybridization assay for Epstein-Barr virus was positive. These findings were diagnostic of plasmablastic lymphoma. Plasmablastic lymphoma is notoriously difficult to diagnose, particularly when it arises in unexpected sites outside of the oral cavity. As an aggressive lymphoma, plasmablastic lymphoma must be considered in the differential diagnosis of a high-grade malignant neoplasm not just in the oral cavity but at non-oral sites including the parotid gland, particularly in an HIV-positive individual.

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Minimum diagnostic criteria for plasmablastic lymphoma of oral/sinonasal region encountered in a tertiary cancer hospital of a developing country

Abstract: A triad of 'rapidly growing lesion with predilection for oral mucosa, classical plasmablastic morphology and limited immunohistochemical panel' can render a reliable diagnosis of PBL, irrespective of HIV and EBV status, especially in developing countries with limited resources.

Cited by 46 publications

References 20 publications

Hematolymphoid lesions of the sinonasal tract

Hematolymphoid lesions of the sinonasal tract

Oral Plasmablastic Lymphoma in a Case with HIV Infection

Plasmablastic Lymphoma Involving the Parotid Gland

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