Minimum stable structure of the receptor for advanced glycation end product possesses multi ligand binding ability

Kumano-Kuramochi, Miyuki; Ohnishi‐Kameyama, Mayumi; Xie, Qiuhong; Niimi, Setsuko; Kubota, Fumie; Komba, Shiro; Machida, Sachiko

doi:10.1016/j.bbrc.2009.05.142

Cited by 14 publications

(7 citation statements)

References 18 publications

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“…On the other hand, when we analyzed the sRAGE levels according to the spirometric pattern, a significant decrease of 1.3 times was registered in those subjects with the restrictive pattern. Supporting these results, reduction of RAGE levels have been reported in persistent systemic inflammation and oxidative stress which are common features of airflow disruption and emphysema in the lungs (Gopal et al, 2014: Kumano-Kuramochi et al, 2009). Additionally, in a recent study, a decrease level of esRAGE (endogenous secretory soluble receptor for advanced glycation endproducts) and total sRAGE in plasma was reported in COPD patients when compared with the levels registered in controls.…”

Section: Discussionsupporting

confidence: 55%

Lung inflammation biomarkers and lung function in children chronically exposed to arsenic

Olivas-Calderón

Recio-Vega

Gandolfi

et al. 2015

Toxicology and Applied Pharmacology

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Evidence suggests that exposure to arsenic in drinking water during early childhood or in utero is associated with an increase in respiratory symptoms and diseases in adulthood, however only a few studies have been carried out during those sensitive windows of exposure. Recently our group demonstrated that exposure to arsenic during early childhood or in utero was associated with impairment in the lung function in children and suggested that this adverse effect could be due to a chronic inflammatory response to the metalloid. Therefore, a cross-sectional study was designed in a cohort of children associating lung inflammatory biomarkers and lung function with urinary As levels. A total of 275 healthy children were partitioned into four study groups according with their As levels. Inflammation biomarkers were measured in sputum by ELISA and the lung function was evaluated by spirometry. Fifty eight percent of the studied children were found to have a restrictive spirometric pattern. In the two highest exposed groups, the Soluble Receptor for Advanced Glycation Endproducts (sRAGE) sputum level was significantly lower and Matrix Metalloproteinase-9 (MMP-9) concentration was higher. When the biomarkers were correlated to the urinary arsenic species, negative associations were found between dimethylarsinic (DMA), monomethylarsenic percentage (%MMA) and dimethylarsinic percentage (%DMA) with sRAGE and positive associations between %DMA with MMP-9 and with the MMP-9/Tissue Inhibitor of Metalloproteinase (TIMP-1) ratio. In conclusion, chronic arsenic exposure of children negatively correlates with sRAGE, and positively correlated with MMP-9 and MMP-9/TIMP-1 levels, and increases the frequency of an abnormal spirometric pattern.

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Section: Discussionsupporting

confidence: 55%

Lung inflammation biomarkers and lung function in children chronically exposed to arsenic

Olivas-Calderón

Recio-Vega

Gandolfi

et al. 2015

Toxicology and Applied Pharmacology

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“…In addition, a great number of activated neutrophils during extracorporeal circulation may explain the decreasing sRAGE levels [27]. sRAGE is known to have multiple protease-sensitive sites, so it might be degraded by neutrophil-derived proteolytic enzymes [28]. …”

Section: Discussionmentioning

confidence: 99%

Plasma sRAGE enables prediction of acute lung injury after cardiac surgery in children

et al. 2012

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IntroductionAcute lung injury (ALI) after cardiac surgery is associated with a high postoperative morbidity and mortality, but few predictors are known for the occurrence of the complication. This study evaluated whether elevated plasma levels of soluble receptor for advanced glycation end products (sRAGE) and S100A12 reflected impaired lung function in infants and young children after cardiac surgery necessitating cardiopulmonary bypass (CPB).MethodsConsecutive children younger than 3 years after cardiac surgery were prospectively enrolled and assigned to ALI and non-ALI groups, according to the American-European Consensus Criteria. Plasma concentrations of sRAGE and S100A12 were measured at baseline, before, and immediately after CPB, as well as 1 hour, 12 hours, and 24 hours after operation.ResultsFifty-eight patients were enrolled and 16 (27.6%) developed postoperative ALI. Plasma sRAGE and S100A12 levels increased immediately after CPB and remained significantly higher in the ALI group even 24 hour after operation (P < 0.01). In addition, a one-way MANOVA revealed that the overall sRAGE and S100A12 levels were higher in the ALI group than in the non-ALI group immediately after CPB (P < 0.001). The multivariate logistic regression analysis showed that the plasma sRAGE level immediately after CPB was an independent predictor for postoperative ALI (OR, 1.088; 95% CI, 1.011 to 1.171; P = 0.025). Increased sRAGE and S100A12 levels immediately after CPB were significantly correlated with a lower PaO2/FiO2 ratio (P < 0.01) and higher radiographic lung-injury score (P < 0.01), as well as longer mechanical ventilation time (sRAGEN: r = 0.405; P = 0.002; S100A12N: r = 0.322; P = 0.014), longer surgical intensive care unit stay (sRAGEN: r = 0.421; P = 0.001; S100A12N: r = 0.365; P = 0.005) and hospital stay (sRAGEN: r = 0.329; P = 0.012; S100A12N: r = 0.471; P = 0.001).ConclusionsElevated sRAGE and S100A12 levels correlate with impaired lung function, and sRAGE is a useful early biomarker of ALI in infants and young children undergoing cardiac surgery.

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“…Intriguingly, recovery of exogenous sRAGE was approximately 45% less in samples from subjects with neutrophilic asthma or COPD, compared with those with non-neutrophilic asthma or COPD. Since sRAGE is known to have multiple protease-sensitive sites [21], these data suggest that sRAGE might be degraded by neutrophil-derived proteolytic enzymes present in BL fluid from subjects with airway neutrophilia. Furthermore, these data raise the possibility that sRAGE might be bound to ligands that interfere with its detection by ELISA in BL fluids from subjects with airway neutrophilia.…”

Section: Mechanisms Of Lung Disease Mb Sukkar Et Almentioning

confidence: 97%

Soluble RAGE is deficient in neutrophilic asthma and COPD

Sukkar¹,

Wood²,

Tooze³

et al. 2011

Eur Respir J

130

112

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The receptor for advanced glycation end-products (RAGE) is a pattern-recognition receptor involved in the host response to injury, infection and inflammation. It is a membrane receptor, but also has soluble forms (sRAGE). Deficiencies in sRAGE are linked to heightened inflammation in various chronic conditions. We determined whether airway and systemic levels of sRAGE and the RAGE ligands HMGB1 (high-mobility group box-1) and serum amyloid A (SAA) are related to neutrophilic inflammation in asthma and chronic obstructive pulmonary disease (COPD).Bronchial lavage fluid from subjects with moderate-to-severe persistent asthma (n516) or COPD (n537), or from healthy controls (n518), was analysed for neutrophils, total sRAGE, endogenous secretory RAGE (esRAGE), HMGB1 and SAA. We also determined systemic levels of sRAGE in a separate group of asthmatic (n5101) and COPD (n534) subjects.Subjects with neutrophilic asthma or COPD had undetectable levels of lung sRAGE, while levels of sRAGE in asthma/COPD without neutrophilia were similar to those in controls. Systemic sRAGE was significantly decreased in subjects with neutrophilic asthma or COPD compared with those without airway neutrophilia. There was significant positive correlation between total sRAGE and esRAGE in the lung and systemically. HMGB1 levels were similar in all subject groups, while SAA was below detectable levels.Neutrophilic airway inflammation in asthma and COPD is associated with reduced sRAGE.

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Minimum stable structure of the receptor for advanced glycation end product possesses multi ligand binding ability

Cited by 14 publications

References 18 publications

Lung inflammation biomarkers and lung function in children chronically exposed to arsenic

Lung inflammation biomarkers and lung function in children chronically exposed to arsenic

Plasma sRAGE enables prediction of acute lung injury after cardiac surgery in children

Soluble RAGE is deficient in neutrophilic asthma and COPD

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