Miniprobe confocal laser microscopy for the detection of invisible neoplasia in patients with Barrett's oesophagus

Pohl, Heiko; Rösch, Thomas; Vieth, Michael; Koch, Martin; Becker, Valentin; Anders, Mario; Khalifa, Ahmed C.; Meining, Alexander

doi:10.1136/gut.2008.157461

Cited by 199 publications

(150 citation statements)

References 21 publications

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“…In further trials, pCLE showed a high negative predictive value (NPV) of 99%, however at the price of a somewhat lower PPV of only 44% [30]. Similar results were obtained from a trial in three expert centers assessing 68 patients with Barrett's esophagus.…”

Section: Endomicroscopy In the Esophagussupporting

confidence: 71%

Confocal Laser Endomicroscopy: Applications in Clinical and Translational Science—A Comprehensive Review

Goetz

2012

ISRN Pathology

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Confocal laser endomicroscopy (CLE) is a novel tool in the endoscopist's armamentarium. It allows on-site histological information. The ability of gastroenterologists to interpret such microscopic information has been demonstrated in multiple studies from the upper and lower gastrointestinal tract. Recently, the field of application has expanded to provide hepatobiliary and intra-abdominal CLE imaging. CLE allows "smart," targeted biopsies and is able to guide endoscopic interventions. But CLE is also translational in its approach and permits functional imaging that significantly impacts on our understanding of gastrointestinal diseases. Molecular imaging with CLE allows detection and characterization of lesions and may even be used for prediction of response to targeted therapy. This paper provides a comprehensive review over current applications of CLE in clinical applications and translational science.

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Section: Endomicroscopy In the Esophagussupporting

confidence: 71%

Confocal Laser Endomicroscopy: Applications in Clinical and Translational Science—A Comprehensive Review

Goetz

2012

ISRN Pathology

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“…[3][4][5][6][7] Endoscopists are exploiting neovascularization in Barrett's esophagus to detect neoplasia using novel imaging modalities, such as narrow band imaging and confocal laser endomicroscopy. [8][9][10][11][12] One of the features that endoscopists look for is the vascular pattern under narrow band imaging or confocal laser endomicroscopy. [8][9][10][11][12] Irregular or increased vascularity is a feature that endoscopists are looking for with these imaging modalities to identify significant superficial neoplasia, including both high-grade dysplasia and esophageal adenocarcinoma.…”

mentioning

confidence: 99%

“…[8][9][10][11][12] One of the features that endoscopists look for is the vascular pattern under narrow band imaging or confocal laser endomicroscopy. [8][9][10][11][12] Irregular or increased vascularity is a feature that endoscopists are looking for with these imaging modalities to identify significant superficial neoplasia, including both high-grade dysplasia and esophageal adenocarcinoma.…”

mentioning

confidence: 99%

Evaluation of microvascular density in Barrett's associated neoplasia

et al. 2013

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Angiogenesis has an important role in the carcinogenesis of esophageal adenocarcinoma, however, the diagnostic and prognostic utility of microvascular density counts have not been clinically established. The aim of this study is to assess the correlation between microvascular density and disease progression of non-dysplastic Barrett's esophagus, low-grade dysplasia, high-grade dysplasia and invasive carcinoma in the superficial aspects of the tissue. Archival histological specimens from two referral centers for Barrett's esophagus and esophageal cancer were selected for review. A total of 160 regions marked according to histological grade were assessed with digitally interactive software to measure microvascular density. This was quantified in three levels: 0-50, 50-100 and 100-150 lm. In the areas of gastric cardia, Barrett's esophagus, low-grade dysplasia, high-grade dysplasia and cancer, microvascular density was significantly different (Po0.0001) among the five groups in the most superficial 150 lm of the mucosa. Furthermore, when examining the pairwise difference between the groups, there was a significant difference between cancer and each of the lower grades of histology (Po0.05) and between high-grade dysplasia and each of the lower grades of histology (Po0.05). These statistically significant differences were preserved in examining the depth at the most superficial 50 lm. We have used digital pathology to demonstrate a significant and stepwise increase in microvascular density, which supports the hypothesis that angiogenesis has a key role in Barrett's carcinogenesis. Furthermore, the differences in the most superficial mucosal layers are consistent with findings of increased vascularity by depth-restricted imaging modalities. Modern Pathology (2013) 26, 125-130; doi:10.1038/modpathol.2012 published online 24 August 2012 Keywords: angiogenesis; Barrett's esophagus; esophageal cancer; microvascular density Angiogenesis has an important role in the carcinogenesis of esophageal adenocarcinoma, however, the diagnostic and prognostic utility of microvascular density counts have not been clinically established. 1,2 Esophageal adenocarcinoma arises from Barrett's esophagus in a metaplasia-dysplasia-carcinoma sequence. Intestinal metaplasia and dysplasia have been studied in terms of microvascular density, and neoangiogenesis is thought to begin in these precursor lesions. [3][4][5][6][7]

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“…др. [10][11][12]. Вместе с тем следует отметить, что изображения конфо-кальной эндомикроскопии по диапазону глубины обе-спечивают визуализацию только поверхности слизистой оболочки и, в отличие от обычного гистологического мето-да, не дают представления о структуре более глубоких слоев.…”

Section: диагностические возможностиunclassified

Modern Methods of Endoscopic Diagnostics and Treatment for Upper Gastrointestinal Tract Diseases in Pediatrics

Андреевич¹,

Kharitonova²,

Шавров³

et al. 2015

Vopr. sovr. pediatr.

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ВВЕДЕНИЕЭндоскопическое исследование -один из наибо-лее информативных методов визуальной диагностики болезней и аномалий развития внутренних органов у детей. Его безопасное и эффективное проведение у пациентов в возрастных категориях от новорожден-ных до подростков требует адекватных медицинских знаний, технического обеспечения и обычно выполняет-ся детским эндоскопистом, обученным по специальной программе подготовки. Однако не всегда эти условия выполнимы, и иногда во взрослой эндоскопической практике возникает необходимость проведения как диагностических, так и лечебных манипуляций у боль-ных детского возраста. Следует отметить, что практиче-ски весь арсенал современных методов внутрипросвет-ного исследования верхнего отдела пищеварительного

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Miniprobe confocal laser microscopy for the detection of invisible neoplasia in patients with Barrett's oesophagus

Abstract: Miniprobe CLM showed a high negative predictive value for the diagnosis of endoscopically invisible neoplasia in Barrett's oesophagus; sensitivity, however, has still to be improved.

Cited by 199 publications

References 21 publications

Confocal Laser Endomicroscopy: Applications in Clinical and Translational Science—A Comprehensive Review

Confocal Laser Endomicroscopy: Applications in Clinical and Translational Science—A Comprehensive Review

Evaluation of microvascular density in Barrett's associated neoplasia

Modern Methods of Endoscopic Diagnostics and Treatment for Upper Gastrointestinal Tract Diseases in Pediatrics

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