Minireview: Regulation of Gap Junction Dynamics by Nuclear Hormone Receptors and Their Ligands

Firestone, Gary L.; Kapadia, Bhumika J.

doi:10.1210/me.2012-1065

Cited by 35 publications

(24 citation statements)

References 68 publications

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“…Even aflatoxin, vomatin, T-2 toxin, and poly aromatic hydrocarbons, while capable of inducing oxidative stress and free radicals, are able to act to induce cell intracellular signaling and altering gene expression [27]. Endogenous chemicals, such as hormones, growth factors and cytokines, are also tumor promoters [43][44][45][46][47]. [49][50][51].…”

Section: Food Safety Is Dependent On Understanding Food Toxicologymentioning

confidence: 99%

Evolving Concepts of Food Safety: The Need for Understanding Mechanisms of Food Toxicology for Public Policy

2018

ANFS

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Nutrition and diet, which are fundamental to human development and health, in the context of food safety, can be major determinants in the prevention and contributor to both acute and chronic diseases. While the predominant and legitimate concern is to detect and eliminate microbial pathogens that can cause acute illnesses and deaths (estimated 3-5 thousand deaths in the United States and millions of various acute disorders), food components (nutrients, pollutants, additives, processing by-products, etc.) are major factors in chronic diseases (e.g., “metabolic diseases” of diabetes, cardiovascular diseases, cancers). They contribute to millions of long-term health problems and deaths, globally. The objective of this “Communication” is to integrate a shared underlying mechanism of toxicity between acute and chronic diseases. The traditional separation of the strategy to understand “causes” of acute and chronic diseases, while for some practical tactics is understandable (i.e. screening for food-associated pathogens), it fails to recognize that these microbial -associated toxins work by exactly the same molecular/biochemical and cellular mechanisms as the toxicants- causing chronic diseases. Since all chemicals work by mutagenic, cytotoxic or “epigenetic” alteration of gene expression at the transcriptional, translational or post-translational levels, understanding characteristics of all three of these toxicological mechanisms is important so that public policy- strategies for prevention of both these classes of food –related diseases can be made and that a solid foundation for the concept of “functional foods” be made. A moral imperative has to be given to the critical role that safe food can make during pregnancy in preventing long-term health effects later in life.

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Section: Food Safety Is Dependent On Understanding Food Toxicologymentioning

confidence: 99%

Evolving Concepts of Food Safety: The Need for Understanding Mechanisms of Food Toxicology for Public Policy

2018

ANFS

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“…For instance, Moreau et al [120] works focalized to carotenoids extracts of the marine diatom Odontella aurita that showed an anti-proliferative effect on cultures of bronchopulmonary and epithelial cells when extracts were added to cell medium. Carotenoids such as astaxanthin or lycopene are active inducers of communication between cells at the cell-gap junctions [100,102,153]. DNA has receptors for specific carotenoids in controlling connexin gene transcription (connexin being a protein that mediates inter-cellular permeability and communication).…”

Section: Bioactivity Of Pigments and Lipids From Plastids Of Marinmentioning

confidence: 99%

Plastids of Marine Phytoplankton Produce Bioactive Pigments and Lipids

et al. 2013

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Phytoplankton is acknowledged to be a very diverse source of bioactive molecules. These compounds play physiological roles that allow cells to deal with changes of the environmental constrains. For example, the diversity of light harvesting pigments allows efficient photosynthesis at different depths in the seawater column. Identically, lipid composition of cell membranes can vary according to environmental factors. This, together with the heterogenous evolutionary origin of taxa, makes the chemical diversity of phytoplankton compounds much larger than in terrestrial plants. This contribution is dedicated to pigments and lipids synthesized within or from plastids/photosynthetic membranes. It starts with a short review of cyanobacteria and microalgae phylogeny. Then the bioactivity of pigments and lipids (anti-oxidant, anti-inflammatory, anti-mutagenic, anti-cancer, anti-obesity, anti-allergic activities, and cardio- neuro-, hepato- and photoprotective effects), alone or in combination, is detailed. To increase the cellular production of bioactive compounds, specific culture conditions may be applied (e.g., high light intensity, nitrogen starvation). Regardless of the progress made in blue biotechnologies, the production of bioactive compounds is still limited. However, some examples of large scale production are given, and perspectives are suggested in the final section.

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“…Connexins (GJC) are a large family of proteins that form gap junction; a single connexin forms hexagonal structures called connexons (nexus type connections). Connexons of two adjacent cells form a gap junction connection [1,2]. e construction of the gap junctions varied, depending on the structure of individual connexons.…”

Section: Introductionmentioning

confidence: 99%

“…e protein structure of individual connexons is responsible for the biophysical properties of gap junction connections [1,3].…”

Section: Introductionmentioning

confidence: 99%

Expression of Selected Connexin and Aquaporin Genes and Real-Time Proliferation of Porcine Endometrial Luminal Epithelial Cells in Primary Culture Model

Wojtanowicz-Markiewicz

Kulus

Knap

et al. 2020

BioMed Research International

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Luminal epithelial cells are the first embryonic-maternal contact site undergoing very specific changes associated with reproductive processes. Cells prepare for embryo development by increasing their volume, with the help of aquaporins that provide a transcellular path of rapid water movement during the secretion and absorption of fluids, as well as connexins enabling the flow of inorganic ions and small molecules. In this work, we have examined how AQPs and Cx’s behave in luminal epithelium primary cell culture. Cells obtained from porcine specimen during slaughter were primarily in vitro cultured for 7 days. Their proliferation patterns were then analyzed using RTCA, with the expression of genes of interest evaluated with the use of immunofluorescence and RT-qPCR. The results of these changes of gene of interest expression were analyzed on each of the seven days of the porcine luminal primary cell culture. Our study showed that the significant changes were noted in the case of Cx43, whose level of protein expression and distribution increases after 120 hours of culture, when the cells enter the lag phase, and maintains an upward trend until the end of the culture. We noted an increase in AQP4, AQP7, AQP8, and AQP11 levels throughout the entire culture period, while the largest differences in expression were found in AQP3, AQP4, and AQP10. The obtained results could become a point of reference for further in vivo and clinical research. Experiments conducted with these proteins showed that they influence the endometrial fluid content during the oestrous cycle and participate in the process of angiogenesis, which intensifies during endometrial development.

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Minireview: Regulation of Gap Junction Dynamics by Nuclear Hormone Receptors and Their Ligands

Cited by 35 publications

References 68 publications

Evolving Concepts of Food Safety: The Need for Understanding Mechanisms of Food Toxicology for Public Policy

Evolving Concepts of Food Safety: The Need for Understanding Mechanisms of Food Toxicology for Public Policy

Plastids of Marine Phytoplankton Produce Bioactive Pigments and Lipids

Expression of Selected Connexin and Aquaporin Genes and Real-Time Proliferation of Porcine Endometrial Luminal Epithelial Cells in Primary Culture Model

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