Minocycline attenuates the development of diabetic neuropathy by inhibiting spinal cord Notch signaling in rat

Yang, Cheng‐Ta; Gao, Jie; Wu, Banglin; Yan, Ning; Li, Hui; Ren, Yiqing; Kan, Yufei; Liang, Jiamin; Jiao, Yang; Yu, Yonghao

doi:10.1016/j.biopha.2017.07.078

Cited by 29 publications

(22 citation statements)

References 32 publications

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“…Moreover, proinflammatory factors such as IL-6, IL-1β, and TNF-α are known to play a critical role in diabetes-causing anxiety and depression [ 62 , 63 , 64 ]. Recently, it was reported that anti-inflammatory drugs such as minocycline, taurine, and eugenol reduce blood glucose levels in STZ-induced diabetic rats and inhibit neuropathy and brain damage caused by hyperglycemia [ 65 , 66 , 67 , 68 ]. Thus, based on these reports, our results suggest that the neuroprotective effect of GS-KG9 and GS-E3D might be mediated by attenuating BBB disruption, thereby preventing neuroinflammation in the hippocampus in STZ-induced chronic diabetic rats.…”

Section: Resultsmentioning

confidence: 99%

Ginseng Extracts, GS-KG9 and GS-E3D, Prevent Blood–Brain Barrier Disruption and Thereby Inhibit Apoptotic Cell Death of Hippocampal Neurons in Streptozotocin-Induced Diabetic Rats

Lee,

Park,

Choi

et al. 2020

Nutrients

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Type 1 diabetes mellitus is known to be linked to the impairment of blood–brain barrier (BBB) integrity following neuronal cell death. Here, we investigated whether GS-KG9 and GS-E3D, bioactive ginseng extracts from Korean ginseng (Panax ginseng Meyer), inhibit BBB disruption following neuronal death in the hippocampus in streptozotocin-induced diabetic rats showing type 1-like diabetes mellitus. GS-KG9 and GS-E3D (50, 150, or 300 mg/kg, twice a day for 4 weeks) administered orally showed antihyperglycemic activity in a dose-dependent manner and significantly attenuated the increase in BBB permeability and loss of tight junction proteins. GS-KG9 and GS-E3D also inhibited the expression and activation of matrix metalloproteinase-9 and the infiltration of macrophages into the brain parenchyma, especially into the hippocampal region. In addition, microglia and astrocyte activation in the hippocampus and the expression of proinflammatory mediators such as tnf-α, Il-1β, IL-6, cox-2, and inos were markedly alleviated in GS-KG9 and GS-E3D-treated group. Furthermore, apoptotic cell death of hippocampal neurons, especially in CA1 region, was significantly reduced in GS-KG9 and GS-E3D-treated groups as compared to vehicle control. These results suggest that GS-KG9 and GS-E3D effectively prevent apoptotic cell death of hippocampal neurons by inhibiting BBB disruption and may be a potential therapy for the treatment of diabetic patients.

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Section: Resultsmentioning

confidence: 99%

Ginseng Extracts, GS-KG9 and GS-E3D, Prevent Blood–Brain Barrier Disruption and Thereby Inhibit Apoptotic Cell Death of Hippocampal Neurons in Streptozotocin-Induced Diabetic Rats

Lee,

Park,

Choi

et al. 2020

Nutrients

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“…daPT treatment has been shown to enhance neovascularization and reperfusion in diabetic mice (28). daPT has also been shown to be effective in the treatment of diabetic neuropathic pain (29).…”

Section: Discussionmentioning

confidence: 99%

Notch inhibitor mitigates renal ischemia‑reperfusion injury in diabetic rats

Duan

Qin

2019

Mol Med Report

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diabetes mellitus can exacerbate renal ischemia-reperfusion (i/r) injury (ri/ri) in diabetic rats. Previous studies have shown that notch signaling is involved in renal disorders. The aim of the present study was to evaluate the protective effect of the notch inhibitor γ-secretase N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (daPT) on ri/ri in a streptozocin (STZ)-induced diabetic rat model. STZ-induced diabetic rats were randomly grouped for different treatments. cisplatin was used to trigger the notch signaling pathway and the animals were preconditioned with daPT to block the signaling pathway. renal function, oxidative stress and inflammatory factors were examined. daPT-treated diabetic rats demonstrated mitigated renal injury and function, antioxidative activity was significantly improved and HiF-1a was upregulated. notch inhibitor daPT is a potential therapeutic target to improve the outcome of ri/ri in STZ-induced diabetic rats in part via the regulation of anti-oxidation and HiF-1a.

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“…This approach could be a potential promise in treatment of neuropathic pain (65). In another somewhat similar study, Yang et al demonstrated the effects of "minocycline combined with DAPT" in treatment of neuropathic pain (73).…”

Section: Activation Of Notch Signaling Pathway and Its Implicationmentioning

confidence: 95%

Meeting Between Rumi and Shams in Notch Signaling; Implications for Pain Management: A Narrative Review

2019

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The meeting between Rumi and Shams, in the 13th century, was a turning point in the life of Rumi leading to a revolutionary effect in his thoughts, ideas, and poems. This was an ever-inspiring meeting with many results throughout the centuries. This meeting has created some footprints in cellular and molecular medicine: The discovery of two distinct genes in Drosophila, i.e. Rumi and Shams and their role in controlling Notch signaling, which has a critical role in cell biology. This nomination and the interactions between the two genes has led us to a number of novel studies during the last years. This article reviews the interactions between Rumi and Shams and their effects on Notch signaling in order to find potential novel drugs for pain control through drug development studies in the future.

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Minocycline attenuates the development of diabetic neuropathy by inhibiting spinal cord Notch signaling in rat

Cited by 29 publications

References 32 publications

Ginseng Extracts, GS-KG9 and GS-E3D, Prevent Blood–Brain Barrier Disruption and Thereby Inhibit Apoptotic Cell Death of Hippocampal Neurons in Streptozotocin-Induced Diabetic Rats

Ginseng Extracts, GS-KG9 and GS-E3D, Prevent Blood–Brain Barrier Disruption and Thereby Inhibit Apoptotic Cell Death of Hippocampal Neurons in Streptozotocin-Induced Diabetic Rats

Notch inhibitor mitigates renal ischemia‑reperfusion injury in diabetic rats

Meeting Between Rumi and Shams in Notch Signaling; Implications for Pain Management: A Narrative Review

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