Minocycline black bone disease in arthroplasty: a systematic review

Steadman, William; Brown, Zak; Wall, Christopher J.

doi:10.1186/s13018-021-02617-w

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…It can rapidly inhibit bacteria and kill viruses, with an analgesic effect to relieve the pain of patients [ 15 ]. Minocycline is a periodontal local sustained-release antibiotic with a strong antibacterial effect and remains intact function in the oral cavity, with a good bactericidal effect and a long antibacterial effect [ 16 ]. Eugenol can improve the pharmacological activity of minocycline, and the combination of zinc oxide eugenol cement with minocycline is associated with a better efficacy for treating acute retrograde pulpitis.…”

Section: Discussionmentioning

confidence: 99%

Minocycline plus Zinc Oxide Eugenol Cement Might Be A Promising Alternative for Acute Pulpitis

Song

Lei

Liu

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the clinical effect of minocycline plus zinc oxide eugenol cement in the treatment of acute pulpitis and its effect on the levels of HIF-1α, Bcl-2, and tumor necrosis factor α. Methods. A total of 286 patients with acute pulpitis who were treated in our hospital from January 2019 to October 2020 were recruited and assigned (1 : 1) via random number table method to receive either minocycline (control group) or minocycline plus zinc oxide eugenol cement (study group). Outcome measures included treatment effect, tooth mobility, tooth percussion pain score, hypoxia-inducible factor (HIF)-1α and B-lymphocyte tumor (Bcl)-2 positive rate, and tumor necrosis factor (TNF-α). Results. Minocycline plus zinc oxide eugenol cement was associated with significantly lower scores of teeth mobility and percussion pain versus minocycline alone ( p < 0.05 ). Minocycline plus zinc oxide eugenol cement resulted in a significantly higher treatment efficacy (97.20%) versus minocycline alone (72.73%) ( p < 0.05 ). Minocycline plus zinc oxide eugenol cement was associated with significantly lower positive rates of HIF-1α and Bcl-2 and lower levels of TNF-α versus minocycline alone ( p < 0.05 ). The patients receiving minocycline plus zinc oxide eugenol cement showed significantly lower visual analogue scale (VAS) scores and faster pain relief versus those given minocycline alone ( p < 0.05 ). Conclusion. Minocycline plus zinc oxide eugenol cement offers a viable alternative for acute pulpitis as it mitigates the pain of patients, alleviates inflammatory responses, and lowers the positive rate of HIF-1α and Bcl-2, so it is worthy of clinical promotion.

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Section: Discussionmentioning

confidence: 99%

Minocycline plus Zinc Oxide Eugenol Cement Might Be A Promising Alternative for Acute Pulpitis

Song

Lei

Liu

2022

Evidence-Based Complementary and Alternative Medicine

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“…However, for humans, skeletal hyperpigmentation, also known as "black bone", is considered a rare phenomenon that may be caused by medications and diseases [26]. Due to the small number of reported cases, it is difficult to form a comprehensive understanding of the mechanism of the skeletal hyperpigmentation [27]. Currently, there are studies investigating cranial pigmentation in zebrafish [28].…”

Section: Pigmentation Imaging For Adult Zebrafish Intra-and Extracran...mentioning

confidence: 99%

Information-Rich Multi-Functional OCT for Adult Zebrafish Intra- and Extracranial Imaging

et al. 2023

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The zebrafish serves as a valuable animal model for both intra- and extracranial research, particularly in relation to the brain and skull. To effectively investigate the development and regeneration of adult zebrafish, a versatile in vivo imaging technique capable of showing both intra- and extracranial conditions is essential. In this paper, we utilized a high-resolution multi-functional optical coherence tomography (OCT) to obtain rich intra- and extracranial imaging outcomes of adult zebrafish, encompassing pigmentation distribution, tissue-specific information, cranial vascular imaging, and the monitoring of traumatic brain injury (TBI). Notably, it is the first that the channels through the zebrafish cranial suture, which may have a crucial function in maintaining the patency of the cranial sutures, have been observed. Rich imaging results demonstrated that a high-resolution multi-functional OCT system can provide a wealth of novel and interpretable biological information for intra- and extracranial studies of adult zebrafish.

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“…Following publication of the original article [ 1 ], the author has added the new information in the funding information.…”

Section: Correction To: Journal Of Orthopaedic Surgery and Research (...mentioning

confidence: 99%

Correction to: Minocycline black bone disease in arthroplasty: a systematic review

2022

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Minocycline black bone disease in arthroplasty: a systematic review

Cited by 6 publications

References 15 publications

Minocycline plus Zinc Oxide Eugenol Cement Might Be A Promising Alternative for Acute Pulpitis

Minocycline plus Zinc Oxide Eugenol Cement Might Be A Promising Alternative for Acute Pulpitis

Information-Rich Multi-Functional OCT for Adult Zebrafish Intra- and Extracranial Imaging

Correction to: Minocycline black bone disease in arthroplasty: a systematic review

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