Minocycline effects on memory and learning impairment in the beta-amyloid-induced Alzheimer’s disease model in male rats using behavioral, biochemical, and histological methods

Mahmoudian, Zahra Gholami; Ghanbari, Ali; Rashidi, Iraj; Amiri, Iraj; Komaki‬, Alireza

doi:10.1016/j.ejphar.2023.175784

Cited by 5 publications

(2 citation statements)

References 80 publications

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“…Another antioxidative mechanism of action related to minocycline is activation of LKB1/AMPK signaling pathway. Minocycline also improved antioxidative capacity and reduced lipid peroxidation in an experimental model of Alzheimer's disease [33]. There are limited data regarding the effects of minocycline on redox balance in cardiovascular system.…”

Section: Discussionmentioning

confidence: 99%

Antioxidative and Cardioprotective Effects of Minocycline in Ischemia/reperfusion Injury in Experimental Model of Hypertension

Rudic,

Stojanovic,

Sobot

et al. 2024

Preprint

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Purpose: Cardiovascular diseases remains leading cause of death and disabilities. Coronary artery occlusion and consequent ischemia leads to acute myocardial infarction, but restoration of blood flow provokes further myocardial damage known as reperfusion injury. Minocycline is possessing anti-inflammatory and anti-apoptotic activity, immune-modulating and antioxidative properties besides its primary antibacterial effect. Recently it gained significant interest in preventing cardiac damage especially due to myocardial ischemia/reperfusion injury (MI/RI). The aim of this study was to assess protective ability of preconditioning and postconditioning of isolated hearts from healthy and spontaneously hypertensive rats with minocycline, on functional recovery and redox status after MI/RI using Langendorfftechnique. Methods: Using sensor in left ventricle, the cardiodynamic parameters were recorded and in the samples of the coronary venous effluent oxidative stress biomarkers were analyzed. Minocycline was injected directly into the coronary vessels, in preconditioning 5 min before global ischemia, and in postconditioning during the first 5 min of reperfusion. Results: Changes in redox balance induced by minocycline were more pronounced in postconditioning fashion of application. Cardioprotective effects of minocycline due to MI/RI are even more pronounced in hypertensive hearts. Conclusion: Minocycline showed significant cardioprotective effects, which was more pronounced in hypertensive compared to healthy hearts. Reduction of pro-oxidative biomarkers was more pronounced in hypertensive hearts compared to the normotensive, especially if it is applied in the form of post-conditioning. The fact that better effects are achieved during postconditioning is particularly important, bearing in mind that it is not possible to predict the occurrence of a heart attack.

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Section: Discussionmentioning

confidence: 99%

Antioxidative and Cardioprotective Effects of Minocycline in Ischemia/reperfusion Injury in Experimental Model of Hypertension

Rudic,

Stojanovic,

Sobot

et al. 2024

Preprint

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show abstract

“…An elevated plus maze test was used to measure anxiety levels ( Gholami Mahmoudian et al, 2023 ). The maze consisted of two open arms without walls (50 × 10 × 0.5 cm), two enclosed arms with walls (50 × 10 × 40 cm), and a central area (10 × 10 cm) elevated at 50 cm height.…”

Section: Methodsmentioning

confidence: 99%

Circular RNA expression profiles and functional predication after restraint stress in the amygdala of rats

Wang,

et al. 2024

Front. Mol. Neurosci.

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Prolonged or repeated exposure to stress elevates the risk of various psychological diseases, many of which are characterized by central nervous system dysfunction. Recent studies have demonstrated that circular RNAs (circRNAs) are highly abundant in the mammalian brain. Although their precise expression and function remain unknown, they have been hypothesized to regulate transcriptional and post-transcriptional gene expression. In this investigation, we comprehensively analyzed whether restraint stress for 2 days altered the circRNA expression profile in the amygdala of male rats. The impact of restraint stress on behavior was evaluated using an elevated plus maze and open field test. Serum corticosterone levels were measured using an enzyme-linked immunosorbent assay. A total of 10,670 circRNAs were identified using RNA sequencing. Ten circRNAs were validated by reverse transcription and quantitative polymerase chain reaction analysis. Gene ontology and Kyoto encyclopedia of genes and genomes pathway analyzes supported the notion that genes associated with differentially expressed circRNAs are primarily implicated in neuronal activity and neurotransmitter transport. Moreover, the three differentially expressed circRNAs showed high specificity in the amygdala. Overall, these findings indicate that differentially expressed circRNAs are highly enriched in the amygdala and offer a potential direction for further research on restraint stress.

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Antioxidative and cardioprotective effects of minocycline in ischemia/reperfusion injury in experimental model of hypertension

Rudic,

Stojanovic,

Sobot

et al. 2024

Mol Cell Biochem

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Minocycline effects on memory and learning impairment in the beta-amyloid-induced Alzheimer’s disease model in male rats using behavioral, biochemical, and histological methods

Cited by 5 publications

References 80 publications

Antioxidative and Cardioprotective Effects of Minocycline in Ischemia/reperfusion Injury in Experimental Model of Hypertension

Antioxidative and Cardioprotective Effects of Minocycline in Ischemia/reperfusion Injury in Experimental Model of Hypertension

Circular RNA expression profiles and functional predication after restraint stress in the amygdala of rats

Antioxidative and cardioprotective effects of minocycline in ischemia/reperfusion injury in experimental model of hypertension

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