2017
DOI: 10.1002/acn3.492
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Minocycline protects against delayed cerebral ischemia after subarachnoid hemorrhage via matrix metalloproteinase‐9 inhibition

Abstract: ObjectiveDelayed cerebral ischemia (DCI) is an independent risk factor for poor outcome after aneurysmal subarachnoid hemorrhage (SAH) and is multifactorial in etiology. While prior studies have suggested a role for matrix metalloproteinase‐9 (MMP‐9) in early brain injury after SAH, its contribution to the pathophysiology of DCI is unclear.MethodsIn the first experiment, wild‐type (WT) and MMP‐9−/− mice were subjected to sham or endovascular perforation SAH surgery. In separate experiments, WT and MMP‐9−/−mice… Show more

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Cited by 25 publications
(34 citation statements)
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“…Middle cerebral artery diameter was measured as previously reported [ 29 , 30 ]. Five or seven days post-SAH, mice were deeply anesthetized with ketamine and xylazine before being serially perfused through the left ventricle with PBS (5mL), 4% paraformaldehyde (15mL), and 20% Indian ink dissolved in 5% gelatin.…”
Section: Methodsmentioning
confidence: 99%
“…Middle cerebral artery diameter was measured as previously reported [ 29 , 30 ]. Five or seven days post-SAH, mice were deeply anesthetized with ketamine and xylazine before being serially perfused through the left ventricle with PBS (5mL), 4% paraformaldehyde (15mL), and 20% Indian ink dissolved in 5% gelatin.…”
Section: Methodsmentioning
confidence: 99%
“…Subarachnoid haemorrhage is a medical emergency and causes high morbidity and mortality for individuals worldwide (Macdonald & Schweizer, 2017). Multiple pathophysiological processes occurring after subarachnoid haemorrhage contribute to the poor outcome, which can broadly be categorized into early brain injury and delayed cerebral ischaemia (Fan et al, 2017; Fernandez et al, 2018; Vellimana et al, 2017). Early brain injury is characterized by neuroinflammation, oxidative stress, cerebral oedema and neuronal cell death.…”
Section: Introductionmentioning
confidence: 99%
“…Secondly, the upregulation of the DcR3 may be significant in SAH due to its proinflammatory actions 30 . Its neutralizing effect on LIGHT/TNFSF14 31 may contribute to the detrimental outcome after aSAH.…”
Section: Discussionmentioning
confidence: 99%