miR-138-5p promotes chicken granulosa cell apoptosis
            <i>via</i>
            targeting
            <i>SIRT1</i>

Yu, Chunlin; Qiu, Mohan; Yin, Huadong; Zhang, Zengrong; Hu, Chenming; Jiang, Xiaosong; Du, Huarui; Li, Qingyun; Li, Jingjing; Xiong, Xingjiang; Yang, Chaowu; Liu, Yiping

doi:10.1080/10495398.2022.2095642

Cited by 6 publications

(1 citation statement)

References 38 publications

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“…In recent years, the role of miR-138-5p in the reproductive system has been gradually revealed. Yu et al discovered that miR-138-5p promotes apoptosis in chicken granulosa cells by targeting deacetylase SIRT1 [34].…”

Section: Discussionmentioning

confidence: 99%

Down-regulation of miR-138-5p by PP2A promoted apoptosis of spermatocytes

Wang,

Liu,

Chen

et al. 2024

Preprint

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Background Protein phosphatase 2A (PP2A) plays a critical and multifaceted role in numerous physiological processes. Previously, we generated germ cell specific knockout mice for the PP2A catalytic subunit alpha subunit (Ppp2cacKO) by the cre-loxp system. Methods and results Through high-throughput miRNA sequencing of testis tissues and real‑time PCR, we identified a significant decrease in the expression of miR-138-5p in the testes of Ppp2cacKO mice. Here, we report that miR-138-5p affects the apoptosis and proliferation of GC2 cells. Importantly, multiple database predictions suggest that miR-138- 5p may target the transcriptional repressor Trps1. Consistent with this finding, we observed a significant overexpression of Trps1 in the testes of Ppp2cacKO mice. In addition, by transfection experiments, we confirmed that miR-138-5p negatively regulated Trps1 expression in GC2 cells. Conclusion In study, our findings suggest that miR-138-5p may promote spermatocyte apoptosis by targeting Trps1 after PP2A enzyme dysfunction.

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Section: Discussionmentioning

confidence: 99%