miR-141-5p Affects the Cell Proliferation and Apoptosis by Targeting <i>BTG1</i> in Cervical Cancer

Ni, Zhenzhen; Shen, Yan; Wang, Wei; Cheng, Xue; Fu, Yajuan

doi:10.1089/cbr.2021.0227

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…The current research on the miR-141 family is mainly focused on inflammation and apoptosis. miR-141-5p can affect cervical cancer cell proliferation and apoptosis by targeting BTG1 [ 37 ]. Li et al [ 38 ] found that miR-141-3p promotes nasopharyngeal carcinoma (NPC) by targeting neoplasm metastasis 1 (NME1).…”

Section: Discussionmentioning

confidence: 99%

Ssc-miR-141 Attenuates Hypoxia-Induced Alveolar Type II Epithelial Cell Injury in Tibetan Pigs by Targeting PDCD4

Yuan

Wang

et al. 2022

Genes

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The Tibetan pig is an endemic economic animal in the plateau region of China, and has a unique adaptation mechanism to the plateau hypoxic environment. Research into microRNAs (miRNAs) involved in the mechanism underlying hypoxia adaptation of Tibetan pig is very limited. Therefore, we isolated alveolar type II epithelial (ATII) cells from the lungs of the Tibetan pig, cultured them in normoxia/hypoxia (21% O2; 2% O2) for 48 h, and performed high-throughput sequencing analysis. We identified a hypoxic stress-related ssc-miR-141 and predicted its target genes. The target genes of ssc-miR-141 were mainly enriched in mitogen-activated protein kinase (MAPK), autophagy-animal, and Ras signaling pathways. Further, we confirmed that PDCD4 may serve as the target gene of ssc-miR-141. Real-time quantitative polymerase chain reaction (RT-qPCR) analysis was performed to confirm the expression levels of ssc-miR-141 and PDCD4, and a dual-luciferase gene reporter system was used to verify the targeted linkage of ssc-miR-141 to PDCD4. The results showed that the expression level of ssc-miR-141 in the hypoxia group was higher than that in the normoxia group, while the expression level of PDCD4 tended to show the opposite trend and significantly decreased under hypoxia. These findings suggest that ssc-miR-141 is associated with hypoxia adaptation and provide a new insight into the role of miRNAs from ATII cells of Tibetan pig in hypoxia adaptation.

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Section: Discussionmentioning

confidence: 99%

Ssc-miR-141 Attenuates Hypoxia-Induced Alveolar Type II Epithelial Cell Injury in Tibetan Pigs by Targeting PDCD4

Yuan

Wang

et al. 2022

Genes

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“…Meanwhile, miR-141 interdicted the migration and invasion of bone metastases. In addition, miR-141 can also induce tumor cell apoptosis, thus playing a momentous role in the process of bone metastases ( 109 , 110 ). In conclusion, miR-141 is instrumental in inhibiting the development of bone metastatic tumors and may be essential in clinical diagnosis and treatment of bone metastatic tumors in the future.…”

Section: Application Of Ncrna As Biomarkers In Bone Metastasesmentioning

confidence: 99%

“…HOTAIR affected and blocked the growth, metastasis, and apoptosis of breast cancer cells through the miR-20a-5p/HMGA2 axis. In the past few years, studies have found that lncRNA-SOX2OT may have clinical diagnostic value and can be employed as an in vitro diagnostic biomarker for bone metastases ( 110 ). It was found that the level of lncRNA-SOX2OT in serum in patients with bone metastases were significantly higher than those in the control group ( 112 ).…”

Section: Application Of Ncrna As Biomarkers In Bone Metastasesmentioning

confidence: 99%

Potential biomarkers for the early detection of bone metastases

Yang

Zhang

et al. 2023

Front. Oncol.

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The clinical manifestations of bone metastases are diversified while many sites remain asymptomatic at early stage. As the early diagnosis method is not perfect and the early symptoms of tumor bone metastasis are not typical, bone metastasis is not easy to be detected. Therefore, the search for bone metastasis-related markers is effective for timely detection of tumor bone metastases and the development of drugs to inhibit bone metastases. As a result, bone metastases can only be diagnosed when symptoms are found, increasing the risk of developing skeletal-related event (SREs), which significantly impairs the patient’s quality of life. Therefore, the early diagnosis of bone metastases is of great importance for the treatment and prognosis of cancer patients. Changes of bone metabolism indexes appear earlier in bone metastases, but the traditional biochemical indexes of bone metabolism lack of specificity and could be interfered by many factors, which limits their application in the study of bone metastases. Some new biomarkers of bone metastases have good diagnostic value, such as proteins, ncRNAs, circulating tumor cells (CTCs). Therefore, this study mainly reviewed the initial diagnostic biomarkers of bone metastases which were expected to provide references for the early detection of bone metastases.

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“…BTG1 was shown to prevent antigen from inducing molecular features of in vitro allergic reactions as a direct target of miR-183-5p (Kim et al, 2020). Ni et al (2021) found that miR-141-5p enhanced the proliferation and inhibited apoptosis by targeting BTG1 in cervical Cancer cells. Cheng et al (2021) revealed that the exosomal miR-301a-3p promotes the proliferation and invasion of nasopharyngeal carcinoma squamous cells by targeting BTG1.…”

Section: Introductionmentioning

confidence: 98%

The roles of BTG1 mRNA expression in cancers: A bioinformatics analysis

Zheng

Xue²,

Zhang³

et al. 2022

Front. Genet.

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BTG1 (B-cell translocation gene 1) may inhibit proliferation and cell cycle progression, induce differentiation, apoptosis, and anti-inflammatory activity. The goal of this study was to clarify the clinicopathological and prognostic significances of BTG1 mRNA expression and related signal pathways in cancers. Using the Oncomine, TCGA (the cancer genome atlas), xiantao, UALCAN (The University of ALabama at Birmingham Cancer data analysis Portal), and Kaplan-Meier plotter databases, we undertook a bioinformatics study of BTG1 mRNA expression in cancers. BTG1 expression was lower in gastric, lung, breast and ovarian cancer than normal tissue due to its promoter methylation, which was the opposite to BTG1 expression. BTG1 expression was positively correlated with dedifferentiation and histological grading of gastric cancer (p < 0.05), with squamous subtype and young age of lung cancer (p < 0.05), with infrequent lymph node metastasis, low TNM staging, young age, white race, infiltrative lobular subtype, Her2 negativity, favorable molecular subtyping, and no postmenopause status of breast cancer (p < 0.05), and with elder age, venous invasion, lymphatic invasion, and clinicopathological staging of ovarian cancer (p < 0.05). BTG1 expression was negatively correlated with favorable prognosis of gastric, lung or ovarian cancer patients, but the converse was true for breast cancer (p < 0.05). KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis showed that the top signal pathways included cytokine-cytokine receptor interaction, cell adhesion molecules, chemokine, immune cell receptor and NF (nuclear factor)-κB signal pathways in gastric and breast cancer. The top hub genes mainly contained CD (cluster of differentiation) antigens in gastric cancer, FGF (fibroblast growth factor)-FGFR (FGF receptor) in lung cancer, NADH (nicotinamide adenine dinucleotide): ubiquinone oxidoreductase in breast cancer, and ribosomal proteins in ovarian cancer. BTG1 expression might be employed as a potential marker to indicate carcinogenesis and subsequent progression, even prognosis.

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miR-141-5p Affects the Cell Proliferation and Apoptosis by Targeting BTG1 in Cervical Cancer

Cited by 7 publications

References 31 publications

Ssc-miR-141 Attenuates Hypoxia-Induced Alveolar Type II Epithelial Cell Injury in Tibetan Pigs by Targeting PDCD4

Ssc-miR-141 Attenuates Hypoxia-Induced Alveolar Type II Epithelial Cell Injury in Tibetan Pigs by Targeting PDCD4

Potential biomarkers for the early detection of bone metastases

The roles of BTG1 mRNA expression in cancers: A bioinformatics analysis

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