miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria

Barker, Kevin R.; Lu, Ziyue; Kim, Hani; Zheng, Ying; Chen, Junmei; Conroy, Andrea L.; Hawkes, Michael; Cheng, Henry S.; Njock, Makon‐Sébastien; Fish, Jason E.; Harlan, John M.; López, José A.; Liles, W. Conrad; Kain, Kevin C.

doi:10.2119/molmed.2016.00139

Cited by 60 publications

(50 citation statements)

References 58 publications

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“…MiR‐155, identified as an oncogenic miRNA, is the product of B‐cell integration cluster gene. Previous studies indicate that miR‐155 may be involved in human atherosclerotic plaques and miR‐155 may be overexpressed in monocytes, macrophages, human coronary artery endothelial cells, and human mesangial cells after treatment with LPS, TNFα, or interferon‐γ . According to our results, LPS could promote miR‐155 expression in HUVECs, which is consistent with those studies.…”

Section: Discussionsupporting

confidence: 92%

Pitavastatin up‐regulates eNOS production by suppressing miR‐155 expression in lipopolysaccharide‐stimulated human umbilical vein endothelial cells

Jing

Guo

Bao

et al. 2017

Cardiovascular Therapeutics

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Section: Discussionsupporting

confidence: 92%

Pitavastatin up‐regulates eNOS production by suppressing miR‐155 expression in lipopolysaccharide‐stimulated human umbilical vein endothelial cells

Jing

Guo

Bao

et al. 2017

Cardiovascular Therapeutics

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“…From a literature search of the PubMed database, we found 62 microRNAs related to immunological and inflammatory responses, cytoadhesion, and neuronal apoptosis (Figure and Supporting Information Table ). Among them, three microRNAs (microRNA‐146a, microRNA‐27a, and microRNA‐155) were related to each of these mechanisms (Barker et al., ). Subsequent miRSNP database searching indicated that the SNP in microRNA‐155 (rs200351615 A>G) has a minor allele frequency of 0.001, too low to reliably detect in the sample size of our study.…”

Section: Discussionmentioning

confidence: 99%

microRNA‐27a and microRNA‐146aSNPin cerebral malaria

Wah

Hananantachai

Patarapotikul

et al. 2019

Molec Gen & Gen Med

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Background During Plasmodium falciparum infection, micro RNA expression alters in brain tissue of mice with cerebral malaria compared to noninfected controls. Micro RNA regulates gene expression post‐transcriptionally to influence biological processes. Cerebral malaria pathology caused mainly by the immunological disorder. We hypothesize that single‐nucleotide polymorphism in a micro RNA influences micro RNA biogenesis or target gene recognition and altering susceptibility to cerebral malaria. Methods We performed a literature search based on immunological mechanism and applied micro RNA ‐related single‐nucleotide polymorphisms database to examine candidate micro RNA SNP s possibly responsible for cerebral malaria. Micro RNA ‐27a and micro RNA ‐146a are supposed to involve in cerebral malaria pathology. To assess the relationship of micro RNA SNP to cerebral malaria outcome, we performed TaqMan Genotyping Assays in 110 cerebral malaria and 207 uncomplicated malaria cases for three candidate micro RNA SNP s (rs895819 of micro RNA ‐27a, rs57095329 and rs2910164 of micro RNA ‐146a). Results Our study detected no significant difference in genotype and allele frequency of individual micro RNA SNP s as well as in haplotypes of micro RNA ‐146a between these two groups of malaria patients in Thailand. Hardy–Weinberg disequilibrium of rs57095329 in the cerebral malaria group showed a heterozygous excess which might be due to natural selection. Conclusion Our data supported that the candidate micro RNA SNP s have no major role to develop cerebral malaria.

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“…13) Increasing reports have suggested that miR-155 is closely involved in the regulation of cell apoptosis, immunity, inflammation, and bloodbrain barrier. [14][15][16] In this study, we suspected that miR-155 might play a vital role in the effect of PNS on the ischemic injury-related inflammation. We first investigated the effect of PNS on the proliferation of SH-SY5Y cells.…”

Section: Introductionmentioning

confidence: 89%

<i>Panax notoginseng</i> Saponins Attenuate Oxygen–Glucose Deprivation/Reoxygenation-Induced Injury in Human SH-SY5Y Cells by Regulating the Expression of Inflammatory Factors through miR-155

Lin

Huang

et al. 2019

Biological & Pharmaceutical Bulletin

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Panax notoginseng saponins (PNS) have been widely used in China to treat stroke. Accumulating evidence has found that microRNA (miR)-155 plays critical roles in the pathology of ischemic stroke. Here we investigated whether PNS plays a protective effect against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced focal inflammation and injury in SH-SY5Y cells by regulating miR-155 expression. Treatment with PNS at a concentration less than 160 µg/mL had no effect on the proliferation of SH-SY5Y cell. In OGD/R-induced SH-SY5Y cells, 160 µg/mL PNS treatment promoted cell proliferation and cell cycle progression, as well as decreased inhibited apoptosis and miR-155 expression. However, overexpression of miR-155 attenuated the promotion effects of PNS on cell proliferation and cell cycle, apoptosis inhibition in OGD/R-induced SH-SY5Y cells. Moreover, 160 µg/mL PNS treatment decreased the levels of interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) in OGD/R-induced SH-SY5Y cells, whereas overexpression of miR-155 reversed PNS-induced decreases in the levels of IL-1β, IL-6, and TNF-α in OGD/R-treated SH-SY5Y cells. In conclusion, PNS attenuated OGD/R-induced injury in human undifferentiated SH-SY5Y cells by regulating the expression of inflammatory factors through miR-155.

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miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria

Cited by 60 publications

References 58 publications

Pitavastatin up‐regulates eNOS production by suppressing miR‐155 expression in lipopolysaccharide‐stimulated human umbilical vein endothelial cells

Pitavastatin up‐regulates eNOS production by suppressing miR‐155 expression in lipopolysaccharide‐stimulated human umbilical vein endothelial cells

microRNA‐27a and microRNA‐146aSNPin cerebral malaria

<i>Panax notoginseng</i> Saponins Attenuate Oxygen–Glucose Deprivation/Reoxygenation-Induced Injury in Human SH-SY5Y Cells by Regulating the Expression of Inflammatory Factors through miR-155

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