MiR-208a-3p functions as an oncogene in colorectal cancer by targeting PDCD4

Wu, Heng‐Lan; Xu, Liang; Chen, Yaou; Xu, Chunfang

doi:10.1042/bsr20181598

Cited by 15 publications

(13 citation statements)

References 36 publications

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“…By contrast, knockdown of miR-208a-3p exhibited the opposite the effects compared with miR-208a-3p mimics. To the best of our knowledge, the present study was the first to demonstrate that miR-208a-3p may serve as an oncogene via regulating cell growth, proliferation and metastasis of OS cells, which was consistent with a previous report indicating that miR-208a-3p as an oncogene promoted colon cancer progression (24).…”

Section: Discussionsupporting

confidence: 93%

“…miR-208a-3p has also been associated with the progression of several types of cancer. For example, miR-208a-3p, as an oncogenic miRNA, has been indicated to suppress apoptosis in gastric cancer cells (23), and promote cell proliferation, invasion and migration in colon cancer via targeting programmed cell death protein 4 (24). However, to the best of our knowledge, the role of miR-208a-3p in OS has not yet been reported.…”

Section: Discussionmentioning

confidence: 97%

“…It has been reported that miR-208a-3p was dysregulated and promoted the development of several types of cancer, including gastric and colon cancer (23,24). The present study aimed to investigate the role of miR-208a-3p in OS.…”

Section: Mir-208a-3p Is Upregulated In Os Tissues and Cell Linesmentioning

confidence: 94%

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MicroRNA‑208a‑3p promotes osteosarcoma progression via targeting PTEN

Wang

et al. 2020

Exp Ther Med

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Osteosarcoma (OS) is a malignant bone tumor with a poor prognosis. Accumulated evidence has suggested that microRNAs (miRNAs/miRs) may function as either oncogenes or tumor suppressors, which are associated with tumorigenesis and the progression of different types of cancer. In the present study, the role of miR-208a-3p in OS was investigated. The expression levels of miR-208a-3p in OS tissues and cell lines were determined via reverse transcription-quantitative PCR (RT-qPCR). MTT and colony formation assays were performed to verify the proliferation rate of OS cells. In addition, the effects of miR-208a-3p on the migration and invasion of OS cells were revealed using wound-healing and Transwell assays, respectively. Furthermore, the association between miR-208a-3p and phosphatase and tensin homolog (PTEN) 3'-untranslated region was determined via luciferase reporter assays, western blot and RT-qPCR analysis. The results indicated that miR-208a-3p was upregulated in OS tissues and cell lines compared with adjacent normal tissues and human osteoblastic cells, respectively. miR-208a-3p overexpression promoted and miR-208a-3p knockdown inhibited OS cells proliferation and metastatic potential. Additionally, PTEN was validated as a direct target of miR-208a-3p and its expression was negatively associate with that of miR-208a-3p in OS cells. Taken together, these results may suggest that miR-208a-3p promoted OS cells proliferation and metastatic potential via targeting PTEN. Therefore, miR-208a-3p may be considered as a diagnostic biomarker for OS.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 97%

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MicroRNA‑208a‑3p promotes osteosarcoma progression via targeting PTEN

Wang

et al. 2020

Exp Ther Med

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“…MiR-208 was described to promote cell proliferation in human esophageal squamous cell carcinoma [ 56 ], promote EMT in pancreatic cancer cells [ 57 ], stimulate tumorigenesis in colorectal cancer [ 58 ], suppress cell apoptosis in gastric cancer [ 59 ], or to facilitate cell proliferation and invasion in non-small cell lung cancer and in hepatocellular carcinoma [ 54 , 60 ]. In 2015, miR-208-3p was found to be transcriptionally regulated by TGFß1 and to directly target ARID2 [ 54 ].…”

Section: Arid2 In Hepatocellular Carcinoma (Hcc)mentioning

confidence: 99%

ARID2 Chromatin Remodeler in Hepatocellular Carcinoma

Loesch

Chenane

Colnot

2020

Cells

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Chromatin remodelers are found highly mutated in cancer including hepatocellular carcinoma. These mutations frequently occur in ARID (AT-rich Interactive Domain) genes, encoding subunits of the ATP-dependent SWI/SNF remodelers. The increasingly prevalent complexity that surrounds the functions and specificities of the highly modular BAF (BG1/BRM-associated factors) and PBAF (polybromo-associated BAF) complexes, including ARID1A/B or ARID2, is baffling. The involvement of the SWI/SNF complexes in diverse tissues and processes, and especially in the regulation of gene expression, multiplies the specific outcomes of specific gene alterations. A better understanding of the molecular consequences of specific mutations impairing chromatin remodelers is needed. In this review, we summarize what we know about the tumor-modulating properties of ARID2 in hepatocellular carcinoma.

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“…MicroRNAs are short (19-23 nucleotides), non-coding, single-stranded RNA molecules that regulate post-translational genes expression by degradation or translation prohibiting of target mRNA [ 8 - 10 ]. MiRNAs are key regulators of the human transcriptome and function as oncogenes or tumor suppressor genes depending on the function of their target genes [ 11 - 14 ].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Pre-miR-3131 3-bp Insertion/Deletion Polymorphism and Susceptibility and Clinicopathological Characteristics of Patients with Breast Cancer

Azizi

Rahimi

Bahari

et al. 2020

MIRNA

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Aims: This study aimed at examining the effect of 3-bp pre-miR-3131 insertion/deletion (ins/del) polymorphism on Breast Cancer (BC) risk. Objectives: Totally 403 women including 199 BC patients and 204 women who have no cancer were included in this case-control study. Genotyping of miR-3131 3-bp ins/del polymorphism was performed by mismatch PCR-RFLP method. Methods: The findings expressed that the pre-miR-3131 3-bp ins/del variant was not related to the risk of BC in all genetic tested models. While, the ins/del genotype was related to late onset BC (OR=2.53, 95%CI=1.27-4.84, p=0.008). Results: Pooled results from the meta-analysis indicated to that the pre-miR-3131 ins/del is related to with an increased risk of cancer in heterozygous (OR=1.26, 95%CI=1.06-1.51, p=0.01), dominant (OR=1.33, 95%CI=1.14-1.54, p=0.0002), and allele (OR=1.24, 95%CI=1.06-1.45, p=0.006) genetics models. Conclusion: It is concluded that, our findings did not support a relationship between pre-miR-3131 ins/del polymorphism and the risk of BC. While, this variant was significantly related to late onset BC. Combined results of this study with previous studies indicated that this polymorphism increased the risk of cancer. More studies in a study with larger population with variety of ethnicities are required to verify our findings.

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MiR-208a-3p functions as an oncogene in colorectal cancer by targeting PDCD4

Cited by 15 publications

References 36 publications

MicroRNA‑208a‑3p promotes osteosarcoma progression via targeting PTEN

MicroRNA‑208a‑3p promotes osteosarcoma progression via targeting PTEN

ARID2 Chromatin Remodeler in Hepatocellular Carcinoma

The Relationship between Pre-miR-3131 3-bp Insertion/Deletion Polymorphism and Susceptibility and Clinicopathological Characteristics of Patients with Breast Cancer

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