MiR-210-5p regulates STAT3 activation by targeting STAT5A in the differentiation of dermal fibroblasts

Wei, Shuyi; Qiu, Ye

doi:10.1007/s13205-021-02777-w

Cited by 8 publications

(5 citation statements)

References 45 publications

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“…STAT5A is involved in β-casein expression via the Jak2/STAT5 signaling pathway [ 9 ]. A dual-luciferase reporter assay using human dermal fibroblasts showed that miR-210-5p directly binds to the 3′-UTR of STAT5A, indicating that miR-210-5p targets STAT5A [ 26 ]. This suggests that the reduced STAT5 levels in cells transfected with the miR-210-5p mimic may be due to a decrease in the STAT5A levels.…”

Section: Discussionmentioning

confidence: 99%

“…A previous study showed that miR-210 (both miR-210-3p and miR-210-5p) is present in breast milk [ 24 ]. miR-210-5p targets STAT5A mRNA and regulates Jak2 signaling [ 25 , 26 ], suggesting that mammary-derived miR-210-5p may be associated with the regulation of β-casein expression via Jak2/STAT5 pathway inhibition in mammary epithelial cells. However, to the best of our knowledge, no studies have investigated whether smoking during lactation affects mammary-derived miR-210-5p expression.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Smoking-induced suppression of β-casein in milk is associated with an increase in miR-210-5p expression in mammary epithelia

Chiba,

Takaguri,

Mikuma

et al. 2024

Biochemistry and Biophysics Reports

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Smoking-induced suppression of β-casein in milk is associated with an increase in miR-210-5p expression in mammary epithelia

Chiba,

Takaguri,

Mikuma

et al. 2024

Biochemistry and Biophysics Reports

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“…While it is known that IL-10 is one of the cytokines activating STAT3—a well-known activator of transcription that plays an important role of renal cell carcinoma development—increased STAT3 activation correlates with both advanced metastatic disease and worse survival in RCC [ 23 ]. It was shown that downregulation of miRNA-210-5p decreased phosphorylated STAT3, whereas miRNA-210-5p overexpression did the opposite, indicating that miRNA-210-5p is involved in STAT3-related signaling in response to TGFβ stimulation [ 19 , 24 ]. Another member of JAK/STAT pathway—STAT5—has been shown to play a vital role in immune cells, and an absence of lymphoid STAT5A leads to a loss of CD8+ and regulatory T cells (Treg).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA Expression Signatures in Clear Cell Renal Cell Carcinoma: High-Throughput Searching for Key miRNA Markers in Patients from the Volga-Ural Region of Eurasian Continent

Gilyazova

Ivanova

Измайлов

et al. 2023

IJMS

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Clear cell renal cell carcinoma (ccRCC) is characterized by high molecular genetic heterogeneity, metastatic activity and unfavorable prognosis. MicroRNAs (miRNA) are 22-nucleotide noncoding RNAs that are aberrantly expressed in cancer cells and have gained serious consideration as non-invasive cancer biomarkers. We investigated possible differential miRNA signatures that may differentiate high-grade ccRCC from primary disease stages. High-throughput miRNAs expression profiling, using TaqMan OpenArray Human MicroRNA panel, was performed in a group of 21 ccRCC patients. The obtained data was validated in 47 ccRCC patients. We identified nine dysregulated miRNAs (miRNA-210, -642, -18a, -483-5p, -455-3p, -487b, -582-3p, -199b and -200c) in tumor ccRCC tissue compared to normal renal parenchyma. Our results show that the combination of miRNA-210, miRNA-483-5p, miRNA-455 and miRNA-200c is able to distinguish low and high TNM ccRCC stages. Additionally, miRNA-18a, -210, -483-5p and -642 showed statistically significant differences between the low stage tumor ccRCC tissue and normal renal tissue. Contrariwise, the high stages of the tumor process were accompanied by alteration in the expression levels of miRNA-200c, -455-3p and -582-3p. Although the biological roles of these miRNAs in ccRCC are not totally unclear, our findings need additional investigations into their involvement in the pathogenesis of ccRCC. Prospective studies with large study cohorts of ccRCC patients are important to further establish the clinical validity of our miRNA markers to predict ccRCC.

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“…Wei, SY et al found that miR-210-5p was upregulated in human dermal fibroblasts treated with TGF-β. By binding STAT5A and inhibiting its expression, the STAT3 signaling pathway was activated to promote the differentiation of human dermal fibroblasts into myofibroblasts [ 107 ].…”

Section: Ncrna Activates or Inhibits Different Signaling Pathways To ...mentioning

confidence: 99%

Noncoding RNAs: Master Regulator of Fibroblast to Myofibroblast Transition in Fibrosis

Zhang

Zhou

Wen

et al. 2023

IJMS

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Myofibroblasts escape apoptosis and proliferate abnormally under pathological conditions, especially fibrosis; they synthesize and secrete a large amount of extracellular matrix (ECM), such as α-SMA and collagen, which leads to the distortion of organ parenchyma structure, an imbalance in collagen deposition and degradation, and the replacement of parenchymal cells by fibrous connective tissues. Fibroblast to myofibroblast transition (FMT) is considered to be the main source of myofibroblasts. Therefore, it is crucial to explore the influencing factors regulating the process of FMT for the prevention, treatment, and diagnosis of FMT-related diseases. In recent years, non-coding RNAs, including microRNA, long non-coding RNAs, and circular RNAs, have attracted extensive attention from scientists due to their powerful regulatory functions, and they have been found to play a vital role in regulating FMT. In this review, we summarized ncRNAs which regulate FMT during fibrosis and found that they mainly regulated signaling pathways, including TGF-β/Smad, MAPK/P38/ERK/JNK, PI3K/AKT, and WNT/β-catenin. Furthermore, the expression of downstream transcription factors can be promoted or inhibited, indicating that ncRNAs have the potential to be a new therapeutic target for FMT-related diseases.

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MiR-210-5p regulates STAT3 activation by targeting STAT5A in the differentiation of dermal fibroblasts

Cited by 8 publications

References 45 publications

Smoking-induced suppression of β-casein in milk is associated with an increase in miR-210-5p expression in mammary epithelia

Smoking-induced suppression of β-casein in milk is associated with an increase in miR-210-5p expression in mammary epithelia

MicroRNA Expression Signatures in Clear Cell Renal Cell Carcinoma: High-Throughput Searching for Key miRNA Markers in Patients from the Volga-Ural Region of Eurasian Continent

Noncoding RNAs: Master Regulator of Fibroblast to Myofibroblast Transition in Fibrosis

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