MiR-25 regulates apoptosis by targeting Bim in human ovarian cancer

Zhang, Haiyan; Zuo, Zhiyi; Lü, Xin; Wang, Li; Wang, Haiyan; Zhu, Zhiling

doi:10.3892/or.2011.1530

Cited by 78 publications

(62 citation statements)

References 20 publications

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“…MiR-25 is a member of the miR-106b~25 cluster, which includes miR-106b, miR-93 and miR-25, that is located within intron 13 of the minichromosome maintenance protein 7 (MCM7) gene on chromosome 7q22.1 [14]. Previous studies have shown that the expression of miR-25 was up-regulated significantly in human stomach cancer, ovarian cancer, and prostate cancer [16-18]. In the study by Kim BH et al, miR-25 was found to be up-regulated in human gastric carcinoma tissues when compared to adjacent non-neoplastic tissues.…”

Section: Discussionmentioning

confidence: 99%

“…The effects of miR-25 abrogation were partly mediated by the intrinsic apoptosis pathway. Many pro-apoptotic proteins such as Bim, Bax and caspase-3 were up-regulated after transfection [18]. However, investigators also found that expression of miR-25 was down-regulated in other cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Accumulating evidence has shown that up-regulation of miR-25 is associated with the prognosis of several human malignant solid tumors, including those of the stomach, ovary and prostate [16-18]. …”

Section: Introductionmentioning

confidence: 99%

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Upregulation of microRNA-25 associates with prognosis in hepatocellular carcinoma

Zhao

Rong

et al. 2014

Diagn Pathol

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BackgroundAccumulating evidence has shown that up-regulation of microRNA-25(miR-25) is associated with the prognosis of several types of human malignant solid tumors. However, whether miR-25 expression has influence on the prognosis of hepatocellular carcinoma (HCC) is still unknown.MethodsThe differentially expressed amount of the miR-25 was validated in triplicate by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Survival rate was analyzed by log-rank test, and survival curves were plotted according to Kaplan–Meier. Multivariate analysis of the prognostic factors was performed with Cox regression model.ResultsThe expression of miR-25 was significantly upregulated in HCC tissues when compared with adjacent normal tissues (p<0.0001). Patients who had high miR-25 expression had a shorter overall survival than patients who had low miR-25 expression (median overall survival, 31.0 months versus 42.9 months, p=0.0192). The multivariate Cox regression analysis indicated that miR-25 expression (HR=2.179; p=0.001), TNM stage (HR=1.782; p=0.014), and vein invasion (HR=1.624; p=0.020) were independent prognostic factors for overall survival.ConclusionOur data suggests that the overexpression of miR-25 in HCC tissues is of predictive value on poor prognosis.Virtual slideThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1989618421114309

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Upregulation of microRNA-25 associates with prognosis in hepatocellular carcinoma

Zhao

Rong

et al. 2014

Diagn Pathol

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“…Consistently, miR-25 promotes cell aggressiveness through down-regulation of desmpcollin-2 and subsequently redistributing adheren junctions and activating β-Catenin signaling in ESCC [188]. In addition, miR-25 has also been found to be highly expressed in ovarian cancer and regulates apoptosis through targeting pro-apoptotic Bim [189]. Additionally, miR-25 promotes apoptosis resistance through targeting TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 in cholangiocarcinoma [190].…”

Section: Introductionmentioning

confidence: 99%

Aberrant regulation of FBW7 in cancer

Wang

Ye²,

Liu³

et al. 2014

Oncotarget

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FBW7 (F-box and WD repeat domain-containing 7) or Fbxw7 is a tumor suppressor, which promotes the ubiquitination and subsequent degradation of numerous oncoproteins including Mcl-1, Cyclin E, Notch, c- Jun, and c-Myc. In turn, FBW7 is regulated by multiple upstream factors including p53, C/EBP-δ, EBP2, Pin1, Hes-5 and Numb4 as well as by microRNAs such as miR-223, miR-27a, miR-25, and miR-129-5p. Given that the Fbw7 tumor suppressor is frequently inactivated or deleted in various human cancers, targeting FBW7 regulators is a promising anti-cancer therapeutic strategy.

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“…miR-15a forms a cluster with miR-16 at the chromosomal region 13q14, and functions as a putative tumor suppressor by targeting the oncogene BCL2 (38,39). miR-25 regulates apoptosis by targeting Bim in human ovarian cancer (40) and miR-195 is regarded as a predictor of poor prognosis in adrenocortical cancer (41). Future studies of these miRNAs may better describe the regulatory mechanisms underlying LSCC.…”

Section: Discussionmentioning

confidence: 99%

Gene expression profiling via bioinformatics analysis reveals biomarkers in laryngeal squamous cell carcinoma

Guan

Zheng

Wen

et al. 2015

Molecular Medicine Reports

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The present study aimed to identify key genes and relevant microRNAs (miRNAs) involved in laryngeal squamous cell carcinoma (LSCC). The gene expression profiles of LSCC tissue samples were analyzed with various bioinformatics tools. A gene expression data set (GSE51985), including ten laryngeal squamous cell carcinoma (LSCC) tissue samples and ten adjacent non-neoplastic tissue samples, was downloaded from the Gene Expression Omnibus. Differential analysis was performed using software package limma of R. Functional enrichment analysis was applied to the differentially expressed genes (DEGs) using the Database for Annotation, Visualization and Integrated Discovery. Protein-protein interaction (PPI) networks were constructed for the protein products using information from the Search Tool for the Retrieval of Interacting Genes/Proteins. Module analysis was performed using ClusterONE (a software plugin from Cytoscape). MicroRNAs (miRNAs) regulating the DEGs were predicted using WebGestalt. A total of 461 DEGs were identified in LSCC, 297 of which were upregulated and 164 of which were downregulated. Cell cycle, proteasome and DNA replication were significantly over-represented in the upregulated genes, while the ribosome was significantly over-represented in the downregulated genes. Two PPI networks were constructed for the up- and downregulated genes. One module from the upregulated gene network was associated with protein kinase. Numerous miRNAs associated with LSCC were predicted, including miRNA (miR)-25, miR-32, miR-92 and miR-29. In conclusion, numerous key genes and pathways involved in LSCC were revealed, which may aid the advancement of current knowledge regarding the pathogenesis of LSCC. In addition, relevant miRNAs were also identified, which may represent potential biomarkers for use in the diagnosis or treatment of the disease.

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MiR-25 regulates apoptosis by targeting Bim in human ovarian cancer

Cited by 78 publications

References 20 publications

Upregulation of microRNA-25 associates with prognosis in hepatocellular carcinoma

Upregulation of microRNA-25 associates with prognosis in hepatocellular carcinoma

Aberrant regulation of FBW7 in cancer

Gene expression profiling via bioinformatics analysis reveals biomarkers in laryngeal squamous cell carcinoma

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