miR-320a serves as a negative regulator in the progression of gastric cancer by targeting RAB14

Li, Yongyuan; Liu, Hongjie; Shao, Junfeng; Xing, Guoqiang

doi:10.3892/mmr.2017.6937

Cited by 24 publications

(20 citation statements)

References 34 publications

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“…Recent studies have revealed the oncogenic role of Rab14 in several cancers 40–45 , which is consistent with our observation. Small monomeric GTPases, like Ras and Rac1, are active when they are bound to GTP, and some studies reported that Rab-GTP was the functional type in cancer progression 46,47 .…”

Section: Discussionsupporting

confidence: 93%

CHML promotes liver cancer metastasis by facilitating Rab14 recycle

et al. 2019

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Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, the underlying mechanisms remain largely elusive. In this study, we report that expression of choroideremia-like (CHML) is increased in HCC, associated with poor survival, early recurrence and more satellite nodules in HCC patients. CHML promotes migration, invasion and metastasis of HCC cells, in a Rab14-dependent manner. Mechanism study reveals that CHML facilitates constant recycling of Rab14 by escorting Rab14 to the membrane. Furthermore, we identify several metastasis regulators as cargoes carried by Rab14-positive vesicles, including Mucin13 and CD44, which may contribute to metastasis-promoting effects of CHML. Altogether, our data establish CHML as a potential promoter of HCC metastasis, and the CHML-Rab14 axis may be a promising therapeutic target for HCC.

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Section: Discussionsupporting

confidence: 93%

CHML promotes liver cancer metastasis by facilitating Rab14 recycle

et al. 2019

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“…MiR-320a has been reported to be a suppressor in tumor cell proliferation and metastasis via targeting oncogenes or cancer suppressors. 25,26 Consistently, we revealed that miR-320a was downregulated in HCC and cell lines. Upregulation of miR-320a remarkably weakened the growth and decreased the migration, invasion abilities of HCC cell.…”

Section: Discussionsupporting

confidence: 68%

<p>lncRNA TMPO-AS1 Exerts Oncogenic Roles in HCC Through Regulating miR-320a/SERBP1 Axis</p>

Wang¹,

Huang²,

Huang³

et al. 2020

OTT

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Background: Previous evidence have shown that long non-coding RNA (lncRNA) TMPO antisense RNA 1 (TMPO-AS1) is involved in the aggressiveness of several cancers. Nevertheless, the precise functions of TMOP-AS1 in hepatocellular carcinoma (HCC) are still unresolved. Materials and Methods: The expressions of TMPO-AS1 and miR-320a were detected in HCC tissues and cells by qRT-RCR. The cell growth, migration and invasion were detected by colony formation, wound healing assay and Transwell assay, respectively. The targeting relation between miR-320a and TMPO-AS1 was predicted by bioinformatics analysis and identified by luciferase reporter gene as well as FISH assay. The expression of SERPINE1 MRNA Binding Protein 1 (SERBP1) was detected by Western blot. The growth of HCC cell was analyzed using transplanted tumor model. Results: Currently, we revealed that TMPO-AS1 was overexpressed in clinical HCC samples and a panel of HCC cell lines. Clinically, a higher level of TMPO-AS1 was connected to the advanced stage of HCC and worse prognosis of patients. Depletion of TMPO-AS1 repressed HCC cell viability, migration ability and invasiveness. Nevertheless, upregulation of TMPO-AS1 caused opposite results. Further studies revealed that lncRNA TMPO-AS1 was largely located in the cytoplasm of HCC cell and sponge miR-320a, resulting in increasing the level of SERBP1 in HCC cell. Finally, TMPO-AS1 silencing suppressed tumor growth of HCC cell in vivo. Conclusion: Collectively, our results suggested that TMPO-AS1 was a promoting factor for the aggressive behaviors of HCC cell.

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“…The electron transport chain proteins are the machinery for generating ATP and changes in these molecules could be postulated to alter the efficiency of intracellular energy production. In brain mitochondria we also found significant differences in two RAS oncogene family RAB proteins 1B and 14, these are GTPases involved in intracellular trafficking between Golgi and endosomes [26,27], there is accumulating evidence that differential regulation of tumour pathway proteins occurs also in species of bats [28–30]. In the skeletal muscle we found many mitochondria specific protein differences.…”

Section: Discussionmentioning

confidence: 69%

A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats

Pollard

Ingram

Ortori

et al. 2019

Aging

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It is accepted that smaller mammals with higher metabolic rates have shorter lifespans. The very few species that do not follow these rules can give insights into interesting differences. The recorded maximum lifespans of bats are exceptional - over 40 years, compared with the laboratory mouse of 4 years. We investigated the differences in the biochemical composition of mitochondria between bat and mouse species. We used proteomics and ultra-high-performance liquid chromatography coupled with high resolution mass spectrometry lipidomics, to interrogate mitochondrial fractions prepared from Mus musculus and Pipistrellus pipistrellus brain and skeletal muscle. Fatty acid binding protein 3 was found at different levels in mouse and bat muscle mitochondria and its orthologues were investigated in Caenorhabditis elegans knock-downs for LBP 4, 5 and 6. In the bat, high levels of free fatty acids and N-acylethanolamine lipid species together with a significantly greater abundance of fatty acid binding protein 3 in muscle (1.8-fold, p =0.037) were found. Manipulation of fatty acid binding protein orthologues in C. elegans suggest these proteins and their role in lipid regulation are important for mitochondrial function.

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miR-320a serves as a negative regulator in the progression of gastric cancer by targeting RAB14

Cited by 24 publications

References 34 publications

CHML promotes liver cancer metastasis by facilitating Rab14 recycle

CHML promotes liver cancer metastasis by facilitating Rab14 recycle

<p>lncRNA TMPO-AS1 Exerts Oncogenic Roles in HCC Through Regulating miR-320a/SERBP1 Axis</p>

A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats

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