miR-601 is a prognostic marker and suppresses cell growth and invasion by targeting PTP4A1 in breast cancer

Hu, Jingye; Yi, Wei; Xuan, Wei; Zhang, Mei‐Yin; Xu, Rui; Zeng, Li‐Si; Huang, Zhijie; Chen, Jingsong

doi:10.1016/j.biopha.2016.02.014

Cited by 37 publications

(30 citation statements)

References 27 publications

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“…Therefore, miR-601 may be considered a promising therapeutic target for patients with HCC. Dysregulation of miR-601 is a frequent molecular event in numerous types of human cancer, and has been identified to be closely associated with the biological mechanism of tumor formation and development (19)(20)(21). miR-601 was downregulated in the plasma of patients with colorectal cancer compared with healthy controls (19).…”

Section: Discussionmentioning

confidence: 99%

“…The dysregulation of miRNA (miR)-601 has been observed in colorectal (19), breast (20) and pancreatic cancer (21); however, to the best of our knowledge, the association between miR-601 and HCC has not yet been investigated. In the present study, the expression levels and clinical value of miR-601 in HCC were determined; the functional roles and underlying mechanism of miR-601 in HCC were additionally examined.…”

Section: Microrna-601 Serves As a Potential Tumor Suppressor In Hepatmentioning

confidence: 99%

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MicroRNA‑601 serves as a potential tumor suppressor in hepatocellular carcinoma by directly targeting PIK3R3

Song

Zhuang

et al. 2019

Mol Med Report

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Recently, microRNAs (miRNAs) have been acknowledged as important regulators of hepatocarcinogenesis and tumor progression. Therefore, identifying the underlying molecular mechanisms of miRNAs in the occurrence and development of hepatocellular carcinoma (HCC) may be important for understanding the pathogenesis of HCC and aid the identification of potential therapeutic strategies. In the present study, miRNA (miR)-601 was significantly downregulated in HCC tissues and cell lines; low miR-601 expression was strongly associated with tumor, node and metastasis staging and lymph node metastasis of patients with HCC. In addition, the overexpression of miR-601 expression significantly inhibited the proliferation and invasion of HCC cells. Regarding the underlying mechanism, phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) was predicted to be a direct target of miR-601 in HCC cells. Furthermore, restoration of PIK3R3 expression in these cells counteracted the inhibitory effects of miR-601 on cell proliferation and invasion in HCC. Notably, miR-601 overexpression inhibited the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway in HCC via the regulation of PIK3R3. Collectively, these results demonstrated that miR-601 may inhibit the progression of HCC by directly targeting PIK3R3 and regulating the AKT/mTOR signaling pathway. Therefore, miR-601 may be an effective therapeutic target for the treatment of patients with HCC.

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Section: Discussionmentioning

confidence: 99%

Section: Microrna-601 Serves As a Potential Tumor Suppressor In Hepatmentioning

confidence: 99%

MicroRNA‑601 serves as a potential tumor suppressor in hepatocellular carcinoma by directly targeting PIK3R3

Song

Zhuang

et al. 2019

Mol Med Report

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“…MiRs are involved in a variety of biological functions and in the majority of known hallmarks of cancer, including initiation, development, and metastasis 8, 9 . Moreover, many studies have suggested that miRs have a prognostic value in several human cancers, such as colorectal 10 , breast 11 , lung 12 , and ovarian 13 cancers. Numerous miR studies that have focused on BC have recently been conducted in the fields of outcome prediction and potential therapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs with prognostic significance in bladder cancer: a systematic review and meta-analysis

Xie

Chen

et al. 2017

Sci Rep

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The aim of this study was to systematically review articles that investigated the prognostic significance of different microRNAs in bladder cancer (BC). We systematically searched PubMed, Web of Science, and Embase to identify relevant studies until March 2016. After screening, 26 studies that involved 2753 patients were included. Results suggested that many miRs expression aberration may predict prognosis in patients with BC. There are six miRs (miR-21, miR-143, miR-155, miR-200, miR-214, and miR-222) were reported by at least two studies, and we performed meta-analysis in the corresponding studies. Accordingly, we found that high miR-21 expression was associated with poor overall survival [OS; hazard ratio (HR) = 3.94, 95% CI 2.08–7.44]. High miR-143 expression was associated with poor progression-free survival (PFS; HR = 3.78, 95% CI 1.61–8.89). High miR-155 expression was associated with poor PFS (HR = 8.10, 95% CI 2.92–22.48). High miR-222 expression was associated with poor OS (HR = 3.39, 95% CI 1.10–10.41). Meanwhile, low miR-214 expression was correlated with poor RFS(HR = 0.34, 95% CI 0.22–0.53). Our comprehensive systematic review concluded that microRNAs, particularly miR-21, miR-143, miR-155, miR-214, and miR-222, could serve as meticulous follow-up markers for early detection of progression or recurrence and even useful therapeutic targets for the treatment in patients with BC.

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“…The most highly upregulated miRNA, miR-601, had been observed to be downregulated in the plasma of colorectal cancer patients compared to healthy controls [24]. The expression of miR-601 was also found to be downregulated in breast cancer tissues compared to adjacent non-cancerous breast tissues overexpression of miR-601 suppressed breast cancer cell migration and invasion [25]. These findings appear to suggest a role for miR-601 as a tumor suppressor and a biomarker for good prognosis, which is in contrast to our observations in the oxaliplatin-resistant HCT116 cells.…”

Section: Discussionmentioning

confidence: 89%

MicroRNA Profiling of Oxaliplatin-Resistant HCT116 Colorectal Cancer Cells

Kosmo¹,

Lee²,

Masroni³

et al. 2017

Oncomedicine

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Aim: To investigate the impact of oxaliplatin resistance on the cellular characteristics and miRNA expression pattern in colorectal cancer cells. Methods: A stable oxaliplatin-resistant colorectal cancer HCT116 cell line was established by exposure to increasing doses of oxaliplatin. Alterations in cytotoxicity, migration, invasion and tumorsphere formation were assessed by MTS assay, modified Boyden chamber assay, and colonosphere assay respectively. The miRNAome of the oxaliplatin-resistant HCT116 cells was analyzed using the TaqMan PCR Human miRNA array. Upregulated miRNAs from the PCR array were validated by real-time reverse transcription-quantitative PCR (RT-qPCR). Results: Oxaliplatin-resistant HCT116 cells exhibited higher migration, invasion and tumorsphere formation compared to parental oxaliplatin-sensitive HCT116 cells. The oxaliplatin-resistant cells showed a distinct miRNA expression profile compared to the parental cells. The expression of miR-601, miR-222, miR-202 and miR-25 were verified by RT-qPCR to be increased in resistant cells. Bioinformatics analyses were used to identify potential target mRNAs of these 4 miRNAs. Conclusion: Results presented in this study provide evidence that oxaliplatin-resistance induces phenotypic changes in colorectal cancer and alterations in miRNA expression. Functional studies on the miRNAs and their target mRNA may enable the discovery of functional pathways to chemoresistance in colorectal cancer.

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miR-601 is a prognostic marker and suppresses cell growth and invasion by targeting PTP4A1 in breast cancer

Cited by 37 publications

References 27 publications

MicroRNA‑601 serves as a potential tumor suppressor in hepatocellular carcinoma by directly targeting PIK3R3

MicroRNA‑601 serves as a potential tumor suppressor in hepatocellular carcinoma by directly targeting PIK3R3

MicroRNAs with prognostic significance in bladder cancer: a systematic review and meta-analysis

MicroRNA Profiling of Oxaliplatin-Resistant HCT116 Colorectal Cancer Cells

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