miR-9 promotes cell proliferation and inhibits apoptosis by targeting LASS2 in bladder cancer

Wang, Haifeng; Zhang, Wei; Zuo, Yigang; Ding, Mei; Ke, Changxing; Yan, Ran; Zhan, Hui; Liu, Jingyu; Wang, Jiansong

doi:10.1007/s13277-015-3713-7

Cited by 60 publications

(52 citation statements)

References 30 publications

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“…Molecular receptor systems, such as transforming growth factor β (TGFβ) receptors, induce a growth state and axonal sprouting in stroke13 and also are key molecules in metastatic transformation in cancer, such as the epithelial–mesenchymal transition 97, 99, 100. Recently described microRNAs that induce neural repair or axonal growth responses, such as miR‐9 and miR‐133,101, 102 are also closely linked to oncogenesis 103, 104, 105. Thus, there is a substantial molecular overlap between gene systems that promote tissue regeneration and recovery in brain and spinal cord injury, including stroke, and also induce initial formation of a cancerous state or promote tumor metastasis.…”

Section: Engaging Cns Tissue Regeneration Is Like Activating a Cancermentioning

confidence: 99%

Emergent properties of neural repair: elemental biology to therapeutic concepts

Carmichael

2016

Annals of Neurology

121

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Stroke is the leading cause of adult disability. The past decade has seen advances in basic science research of neural repair in stroke. The brain forms new connections after stroke, which have a causal role in recovery of function. Brain progenitors, including neuronal and glial progenitors, respond to stroke and initiate a partial formation of new neurons and glial cells. The molecular systems that underlie axonal sprouting, neurogenesis, and gliogenesis after stroke have recently been identified. Importantly, tractable drug targets exist within these molecular systems that might stimulate tissue repair. These basic science advances have taken the field to its first scientific milestone; the elemental principles of neural repair in stroke have been identified. The next stages in this field involve understanding how these elemental principles of recovery interact in the dynamic cellular systems of the repairing brain. Emergent principles arise out of the interaction of the fundamental or elemental principles in a system. In neural repair, the elemental principles of brain reorganization after stroke interact to generate higher order and distinct concepts of regenerative brain niches in cellular repair, neuronal networks in synaptic plasticity, and the distinction of molecular systems of neuroregeneration. Many of these emergent principles directly guide the development of new therapies, such as the necessity for spatial and temporal control in neural repair therapy delivery and the overlap of cancer and neural repair mechanisms. This review discusses the emergent principles of neural repair in stroke as they relate to scientific and therapeutic concepts in this field. Ann Neurol 2016;79:895–906

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Section: Engaging Cns Tissue Regeneration Is Like Activating a Cancermentioning

confidence: 99%

Emergent properties of neural repair: elemental biology to therapeutic concepts

Carmichael

2016

Annals of Neurology

121

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“…To our knowledge the experiments by Tan et al, were not carried out at multiple cell densities, and it would be interesting to test if miR-9/CREB feedback was altered by different cell seeding numbers. Indeed, reports of the influence of miR-9 upon tumor migration and proliferation are conflicting [13,54,63]. Our data suggests that some of the differences observed might be due to different cell densities in experiments.…”

Section: Discussionmentioning

confidence: 66%

Density-Dependent Regulation of Glioma Cell Proliferation and Invasion Mediated by miR-9

Katakowski

Charteris

Chopp

et al. 2016

Cancer Microenvironment

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The phenotypic axis of invasion and proliferation in malignant glioma cells is a well-documented phenomenon. Invasive glioma cells exhibit a decreased proliferation rate and a resistance to apoptosis, and invasive tumor cells dispersed in brain subsequently revert to proliferation and contribute to secondary tumor formation. One miRNA can affect dozens of mRNAs, and some miRNAs are potent oncogenes. Multiple miRNAs are implicated in glioma malignancy, and several of which have been identified to regulate tumor cell motility and division. Using rat 9 L gliosarcoma and human U87 glioblastoma cell lines, we investigated miRNAs associated with the switch between glioma cell invasion and proliferation. Using micro-dissection of 9 L glioma tumor xenografts in rat brain, we identified disparate expression of miR-9 between cells within the periphery of the primary tumor, and those comprising tumor islets within the invasive zone. Modifying miR-9 expression in in vitro assays, we report that miR-9 controls the axis of glioma cell invasion/proliferation, and that its contribution to invasion or proliferation is biphasic and dependent upon local tumor cell density. In addition, immunohistochemistry revealed elevated hypoxia inducible factor 1 alpha (HIF-1α) in the invasive zone as compared to the primary tumor periphery. We also found that hypoxia promotes miR-9 expression in glioma cells. Based upon these findings, we propose a hypothesis for the contribution of miR-9 to the dynamics glioma invasion and satellite tumor formation in brain adjacent to tumor.

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“…Recently, miR-9 has been discovered to be involved in modulating [36,37], while knock-down of miR-9 could inhibit cancer cell growth in vitro [38]. In most clinical studies, as a widely accepted method in medical science, qRT-PCR was used to detect the miR-9 expression level.…”

Section: Discussionmentioning

confidence: 99%