miR149 rs71428439 polymorphism and risk of clear cell renal cell carcinoma: a case–control study

Abstract

Clear cell renal cell carcinoma (CCRCC) is the most common subtype of renal cell cancer and accounts for 70 % of renal cell cancer. CCRCC remains an enigmatic tumor type, as the molecular genetic mechanisms are still unclear. MicroRNA (miR) 149 functions as a tumor suppressor and plays an important role in the carcinogenesis of renal cells. In this study, we enrolled 1,000 CCRCC patients and 1,000 cancer-free controls to evaluate the association of miR149 rs71428439 with the risk of CCRCC by a case-control study to determine the effects on CCRCC risk. miR149 rs71428439 was significantly associated with increased CCRCC risk (odds ratio (OR) for trend = 1.53, P for trend = 4.04 × 10(-11)), with ORs (95 % confidence intervals (CIs)) of 1.42 (1.17-1.72) associated with AG genotype and 2.27 (1.76-2.94) associated with GG genotype, compared with subjects with AA genotype. The expression levels of miR149 in cancer tissues were significantly lower than those in adjacent normal tissues (P = 0.005), and per G allele has significantly lower miR149 levels in both tumor tissues and adjacent normal tissues. Our data suggest that the GG genotypes of miR149 rs71428439 predispose their carriers to CCRCC, and miR149 rs71428439 may be a new biomarker for predicting the risk of CCRCC.

miR-149 in Human Cancer: A Systemic Review

“…[79, 80] The study from Wang Z et al also demonstrated that the GG genotypes of miR-149-5p rs71428439 increased the risk of clear cell renal cell carcinoma. 81 But miR-149-5p rs2292832 T/C polymorphism could decrease digestive cancer susceptibility in Li L et al's meta-analysis study. 82 Wang et al found that pre-mir-149-5p rs2292382 had significantly better survival in laryngeal squamous cell carcinoma.…”

Functional miRNA variants affect lung cancer susceptibility and platinum-based chemotherapy response

“…These made it possible to do a rapid screening of lung cancer risk and drug resistance about A, polymorphisms and risk of lung cancer; B, polymorphisms and evaluation of platinum-based chemotherapy response. MiRNAs are a class of small non-coding RNA molecules, play important roles in many biological and physiological processes, aberrant microRNA expression has been found in several diseases including lung cancer (23)(24)(25)(26)(27)(28). MiR-149 is down regulated in several cancer types (29,30) and is believed to act as a versatile tumor-suppression miRNA by regulating the expression of many genes such as AKT1 (31), GIT1 (32), ZBTB2 (33), FOXM1 (34).…”

“…MiR-149 is down regulated in several cancer types (29,30) and is believed to act as a versatile tumor-suppression miRNA by regulating the expression of many genes such as AKT1 (31), GIT1 (32), ZBTB2 (33), FOXM1 (34). Recently studies showed that miR-149 rs71428439 polymorphism was significantly associated with increased clear cell renal cell carcinoma (CCRCC) and hepatocellular carcinoma (HCC) risk (28,35). We didn't find the association of this polymorphism with lung cancer risk in this study, but in NSCLC, female, age under 57 years subgroups, carriers with A allele of this mutation has a higher risk of lung cancer.…”

Association between SNPs in vascular endothelial growth factor polymorphisms and risk of renal cell carcinoma: a case-control study

“…Early diagnosis and medical treatment seems important in decreasing mortality and increasing total quality of life. Several studies have suggested that genetic factors are involved in the development of RCC (Wang et al, 2014;Meng et al, 2014Meng et al, , 2015.…”