MIRACLE: Green tea extract versus placebo for the prevention of colorectal adenomas: A randomized, controlled trial

Seufferlein, T; Ettrich, Thomas Jens; Menzler, Stefan; Messmann, Helmut; Kleber, Gerhard; Zipprich, Alexander; Frank-Gleich, Stefanie; Algül, Hana; Metter, K; Odemar, Frank; Heuer, T.; Hügle, Ulrich; Behrens, Rüdiger; Perkhofer, Lukas; Scholl, Catharina; Schneider, Katharina; Rohlmann, Friederike; Muche, Rainer; Stingl, Julia

doi:10.1093/annonc/mdz394.023

Cited by 5 publications

(3 citation statements)

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“…The use of green tea extract after polypectomy may be beneficial for the prevention of colorectal adenoma [227,228]. Green tea consumption has been reported to reduce the risk of colorectal and other cancers, but evidence for its effect on cancer prevention and mortality has not been confirmed or has been limited to the highest category of green tea consumption compared to the lowest [45].…”

Section: Polyphenolsmentioning

confidence: 99%

The Potential of Integrative Cancer Treatment Using Melatonin and the Challenge of Heterogeneity in Population-Based Studies: A Case Report of Colon Cancer and a Literature Review

Smorodin,

Chuzmarov,

Veidebaum

2024

Current Oncology

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Melatonin is a multifunctional hormone regulator that maintains homeostasis through circadian rhythms, and desynchronization of these rhythms can lead to gastrointestinal disorders and increase the risk of cancer. Preliminary clinical studies have shown that exogenous melatonin alleviates the harmful effects of anticancer therapy and improves quality of life, but the results are still inconclusive due to the heterogeneity of the studies. A personalized approach to testing clinical parameters and response to integrative treatment with nontoxic and bioavailable melatonin in patient-centered N-of-1 studies deserves greater attention. This clinical case of colon cancer analyzes and discusses the tumor pathology, the adverse effects of chemotherapy, and the dynamics of markers of inflammation (NLR, LMR, and PLR ratios), tumors (CEA, CA 19-9, and PSA), and hemostasis (D-dimer and activated partial thromboplastin time). The patient took melatonin during and after chemotherapy, nutrients (zinc, selenium, vitamin D, green tea, and taxifolin), and aspirin after chemotherapy. The patient’s PSA levels decreased during CT combined with melatonin (19 mg/day), and melatonin normalized inflammatory markers and alleviated symptoms of polyneuropathy but did not help with thrombocytopenia. The results are analyzed and discussed in the context of the literature on oncostatic and systemic effects, alleviating therapy-mediated adverse effects, association with survival, and N-of-1 studies.

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Section: Polyphenolsmentioning

confidence: 99%

The Potential of Integrative Cancer Treatment Using Melatonin and the Challenge of Heterogeneity in Population-Based Studies: A Case Report of Colon Cancer and a Literature Review

Smorodin,

Chuzmarov,

Veidebaum

2024

Current Oncology

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“…CRC patients with curative resections were administered orally with 450 mg of EGCG twice daily. Blood was drawn from the patients at 0, 3, 6, 9, 12, 15, and 18 months and a colonoscopy was done after a year (141). Furthermore, lycopene, a carotenoid, was also tested against metastatic CRC and was found to decrease skin toxicity associated disease as a single drug or in combination with panitumumab (31).…”

Section: Alkaloids and Other Phytocompounds In Clinical Trials Agains...mentioning

confidence: 99%

Reactive oxygen species mediated apoptotic death of colon cancer cells: therapeutic potential of plant derived alkaloids

Nelson,

Nuli,

Mastanaiah

et al. 2023

Front. Endocrinol.

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Colorectal cancer (CRC) is one of the most deaths causing diseases worldwide. Several risk factors including hormones like insulin and insulin like growth factors (e.g., IGF-1) have been considered responsible for growth and progression of colon cancer. Though there is a huge advancement in the available screening as well as treatment techniques for CRC. There is no significant decrease in the mortality of cancer patients. Moreover, the current treatment approaches for CRC are associated with serious challenges like drug resistance and cancer re-growth. Given the severity of the disease, there is an urgent need for novel therapeutic agents with ideal characteristics. Several pieces of evidence suggested that natural products, specifically medicinal plants, and derived phytochemicals may serve as potential sources for novel drug discovery for various diseases including cancer. On the other hand, cancer cells like colon cancer require a high basal level of reactive oxygen species (ROS) to maintain its own cellular functions. However, excess production of intracellular ROS leads to cancer cell death via disturbing cellular redox homeostasis. Therefore, medicinal plants and derived phytocompounds that can enhance the intracellular ROS and induce apoptotic cell death in cancer cells via modulating various molecular targets including IGF-1 could be potential therapeutic agents. Alkaloids form a major class of such phytoconstituents that can play a key role in cancer prevention. Moreover, several preclinical and clinical studies have also evidenced that these compounds show potent anti-colon cancer effects and exhibit negligible toxicity towards the normal cells. Hence, the present evidence-based study aimed to provide an update on various alkaloids that have been reported to induce ROS-mediated apoptosis in colon cancer cells via targeting various cellular components including hormones and growth factors, which play a role in metastasis, angiogenesis, proliferation, and invasion. This study also provides an individual account on each such alkaloid that underwent clinical trials either alone or in combination with other clinical drugs. In addition, various classes of phytochemicals that induce ROS-mediated cell death in different kinds of cancers including colon cancer are discussed.

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“…A multicenter study in Germany examined the effect of 3-year treatment of 300 mg per day EGCG on colorectal adenoma incidence rate in patients after colorectal polypectomy. The treatment group showed a slightly lower incidence rate than in the placebo group though the difference was not statistically significant [121]. Intending to test whether the effects of ellagitannins to modify colon gene expression observed in vitro could be reproduced in humans, the trial involved patients with malignant colon biopsy with 5-35 days supplementation with ellagitannins and ellagic acid-containing pomegranate extract cap-sules.…”

Section: Colorectalmentioning

confidence: 99%

Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans

et al. 2021

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Drugs are bioactive compounds originally discovered from chemical structures present in both the plant and animal kingdoms. These have the ability to interact with molecules found in our body, blocking them, activating them, or increasing or decreasing their levels. Their actions have allowed us to cure diseases and improve our state of health, which has led us to increase the longevity of our species. Among the molecules with pharmacological activity produced by plants are the polyphenols. These, due to their molecular structure, as drugs, also have the ability to interact with molecules in our body, presenting various pharmacological properties. In addition, these compounds are found in multiple foods in our diet. In this review, we focused on discussing the bioavailability of these compounds when we ingested them through diet and the specific mechanisms of action of polyphenols, focusing on studies carried out in vitro, in animals and in humans over the last five years. Knowing which foods have these pharmacological activities could allow us to prevent and aid as concomitant treatment against various pathologies.

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MIRACLE: Green tea extract versus placebo for the prevention of colorectal adenomas: A randomized, controlled trial

Cited by 5 publications

References 0 publications

The Potential of Integrative Cancer Treatment Using Melatonin and the Challenge of Heterogeneity in Population-Based Studies: A Case Report of Colon Cancer and a Literature Review

The Potential of Integrative Cancer Treatment Using Melatonin and the Challenge of Heterogeneity in Population-Based Studies: A Case Report of Colon Cancer and a Literature Review

Reactive oxygen species mediated apoptotic death of colon cancer cells: therapeutic potential of plant derived alkaloids

Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans

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