2019
DOI: 10.1101/769307
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miRCoop: Identifying Cooperating miRNAs via Kernel Based Interaction Tests

Abstract: Although miRNAs can cause widespread changes on expression programs, single miRNAs typically induce mild repression on their targets. Cooperativity is reported as one strategy to overcome this constraint. Expanding the catalog of synergistic miRNAs is critical for understanding the regulation of various gene expression programs. In this study, we develop miRCoop to identify synergistic miRNA pairs which have weak or no repression on the target mRNA, but when bound together induce strong repression of their tar… Show more

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