miRNA regulated pathways in late stage murine lung development

Mujahid, Sana; Logvinenko, Tanya; Volpe, MaryAnn V.; Nielsen, Heber C.

doi:10.1186/1471-213x-13-13

Cited by 45 publications

(38 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mele et al identified 92 protein-coding genes differentially expressed in males and females across multiple human tissues [22]. In agreement with human studies, Yang et al identified 2871 genes from the mouse genome with differential expression by sex in multiple somatic tissues [23,24], while another study identified 25 of 376 miRNAs in fetal mouse lung that were also differentially expressed by sex [25]. Sex-specific differences were also shown for DNA methylation and histone acetylation.…”

supporting

confidence: 63%

miRNAs Differentially Expressed by Next-Generation Sequencing in Cord Blood Buffy Coat Samples of Boys and Girls

et al. 2016

View full text Add to dashboard Cite

Aim: Differences in children's development and susceptibility to diseases and exposures have been observed by sex, yet human studies of sex differences in miRNAs are limited. Materials & methods: The genome-wide miRNA expression was characterized by sequencing-based EdgeSeq assay in cord blood buffy coats from 89 newborns, and 564 miRNAs were further analyzed. Results: Differential expression of most miRNAs was higher in boys. Neurodevelopment, RNA metabolism and metabolic ontology terms were enriched among miRNA targets. The majority of upregulated miRNAs (86%) validated by nCounter maintained positive-fold change values; however, only 21% reached statistical significance by false discovery rate. Conclusion: Accounting for host factors like sex may improve the sensitivity of epigenetic analyses for epidemiological studies in early childhood.

show abstract

supporting

confidence: 63%

miRNAs Differentially Expressed by Next-Generation Sequencing in Cord Blood Buffy Coat Samples of Boys and Girls

et al. 2016

View full text Add to dashboard Cite

show abstract

“…However, due to the effect of androgens on branching morphogenesis (11), it is possible that, earlier in gestation, the development of the male lung is more advanced than in the female. MicroRNAs that are significantly different between sexes during murine lung development have been identified (28). We previously determined that genes that are important in lung development might be associated with lung function in subjects with asthma (9).…”

Section: Discussionmentioning

confidence: 99%

Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome

Kho

Chhabra

Sharma

et al. 2016

Am J Respir Cell Mol Biol

View full text Add to dashboard Cite

The fetal origins of disease hypothesis suggests that variations in the course of prenatal lung development may affect life-long pulmonary function growth, decline, and pathobiology. Many studies support the existence of differences in the developing lung trajectory in males and females, and sex-specific differences in the prevalence of chronic lung diseases, such as asthma and bronchopulmonary dysplasia. The objectives of this study were to investigate the early developing fetal lung for transcriptomic correlates of postconception age (maturity) and sex, and their associations with chronic lung diseases. We analyzed whole-lung transcriptome profiles of 61 females and 78 males at 54-127 days postconception (dpc) from nonsmoking mothers using unsupervised principal component analysis and supervised linear regression models. We identified dominant transcriptomic correlates for postconception age and sex with corresponding gene sets that were enriched for developing lung structural and functional ontologies. We observed that the transcriptomic sex difference was not a uniform global time shift/lag, rather, lungs of males appear to be more mature than those of females before 96 dpc, and females appear to be more mature than males after 96 dpc. The age correlate gene set was consistently enriched for asthma and bronchopulmonary dysplasia genes, but the sex correlate gene sets were not. Despite sex differences in the developing fetal lung transcriptome, postconception age appears to be more dominant than sex in the effect of early fetal lung developments on disease risk during this early pseudoglandular phase of development.

show abstract

“…Two miRNAs: miR-146 and miR-203 are associated with psoriasis and have specific pattern of expression in patients (Sonkoly et al, 2007;Nestle et al, 2009). Rheumatoid arthritis (RA) characterized by chronic inflammation of synovial tissue was also reported by various studies to be associated with miR-155, miR-146, miR-132, miR16, miR-346 and miR-223 expression change compared with healthy people (Alsaleh et al, 2009;Pauley et al, 2009;Fulci et al, 2010).…”

Section: Mirnas and Autoimmune Diseasesmentioning

confidence: 99%

“…The first four stages occur during gestation, and the final stage starts at 24 th week and continues through early childhood (Bhaskaran et al, 2009;Mujahid et al, 2013).…”

Section: Lung Development and Mirnasmentioning

confidence: 99%

“…Many authors have stated that the expression of miRNAs is distinctly dissimilar in the early stages of lung organogenesis to adulthood stage. Therefore, we classified miRNA signatures in each stage to make the whole lung development expression profiling conceivable which is shown in table below (supplemental data, Table 3 (Lu et al, 2008;Bhaskaran et al, 2009;Dong et al, 2010;Tang et al, 2011;Mujahid et al, 2013)). …”

Section: Lung Development and Mirnasmentioning

confidence: 99%

See 1 more Smart Citation

MiRNA Molecular Profiles in Human Medical Conditions: Connecting Lung Cancer and Lung Development Phenomena

Aghanoori¹,

Mirzaei²,

Tavallaei³

2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

MiRNAs are endogenous, single stranded ~22-nucleotide non-coding RNAs (ncRNAs) which are transcribed by RNA polymerase II and mediate negative post-transcriptional gene regulation through binding to 3'untranslated regions (UTR), possibly open reading frames (ORFs) or 5'UTRs of target mRNAs. MiRNAs are involved in the normal physiology of eukaryotic cells, so dysregulation may be associated with diseases like cancer, and neurodegenerative, heart and other disorders. Among all cancers, lung cancer, with high incidence and mortality worldwide, is classified into two main groups: non-small cell lung cancer and small cell lung cancer. Recent promising studies suggest that gene expression profiles and miRNA signatures could be a useful step in a noninvasive, low-cost and repeatable screening process of lung cancer. Similarly, every stage of lung development during fetal life is associated with specific miRNAs. Since lung development and lung cancer phenomena share the same physiological, biological and molecular processes like cell proliferation, development and shared mRNA or expression regulation pathways, and according to data adopted from various studies, they may have partially shared miRNA signature. Thus, focusing on lung cancer in relation to lung development in miRNA studies might provide clues for lung cancer diagnosis and prognosis.

show abstract

miRNA regulated pathways in late stage murine lung development

Cited by 45 publications

References 55 publications

miRNAs Differentially Expressed by Next-Generation Sequencing in Cord Blood Buffy Coat Samples of Boys and Girls

miRNAs Differentially Expressed by Next-Generation Sequencing in Cord Blood Buffy Coat Samples of Boys and Girls

Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome

MiRNA Molecular Profiles in Human Medical Conditions: Connecting Lung Cancer and Lung Development Phenomena

Contact Info

Product

Resources

About