miRNAs in cerebrospinal fluid identify patients with MS and specifically those with lipid-specific oligoclonal IgM bands

Abstract

Our study confirms the recent findings regarding the deregulated expression of miR-150 not only with MS but also with the presence of LS_OCMB. This study highlights the potential utility of miRNAs in CSF as biomarkers for MS.

Evaluation of serum miR-191-5p, miR-24-3p, miR-128-3p, and miR-376c-3 in multiple sclerosis patients

“…[7][8][9][10][11] Active and chronic lesions seen in MRI were shown to have distinct miRNA profiles in MS. 7 Moreover, aberrant miRNA expression levels were detected in peripheral blood mononuclear cells, as well as in T and B lymphocytes. [7][8][9][10][11] Active and chronic lesions seen in MRI were shown to have distinct miRNA profiles in MS. 7 Moreover, aberrant miRNA expression levels were detected in peripheral blood mononuclear cells, as well as in T and B lymphocytes.…”

“…Although miRNAs are marginally new era in MS research, there are some significant discoveries published. [7][8][9][10][11] Active and chronic lesions seen in MRI were shown to have distinct miRNA profiles in MS. 7 Moreover, aberrant miRNA expression levels were detected in peripheral blood mononuclear cells, as well as in T and B lymphocytes. 7 Furthermore, deviant expression levels of circulating miR-NAs associated with the MS subtypes were reported in CSF 7,8 and in blood.…”

“…[7][8][9][10][11] Active and chronic lesions seen in MRI were shown to have distinct miRNA profiles in MS. 7 Moreover, aberrant miRNA expression levels were detected in peripheral blood mononuclear cells, as well as in T and B lymphocytes. 7 Furthermore, deviant expression levels of circulating miR-NAs associated with the MS subtypes were reported in CSF 7,8 and in blood. [9][10][11] For example, miR-660, miR-939, and miR-145 were found to be aberrantly expressed in plasma of RRMS patients, 11 while let-7c, let-7d, miR-92a-1*, miR-135a, miR-145, miR-454, miR-500, and miR-574-3p were differentially expressed in plasma of patients with secondary progressive MS (SPMS) in comparison with RRMS.…”

“…A recent CSF study has shown decreased levels of soluble miR-191 in treatment-naive MS patients especially in those positive for lipidspecific immunoglobulin M oligoclonal bands (LS-OCMB)8 as compared to patients with other neurological diseases. The presence of LS-OCMB in CSF was found to be associated with poorer longterm outcome 15.…”

Profiling of small non-coding RNAs across cellular and biofluid compartments: implications for multiple sclerosis immunopathology

“…Functionally, these miRNAs have been implicated in immune processes including differentiation and function of CD4 + T helper cells 9,10,11 . Other miRNAs, such as miR-150 and miR-181c, which are upregulated in MS, have been proposed as biomarkers of different stages of disease, including early active MS 12,13 . However, studies that profile miRNAs using unbiased genome-wide approaches and investigate other classes of sncRNAs are still scarce 8 .…”