Miscellaneous Central Nervous System Intoxicants

Hedge, Matthew

doi:10.1016/j.ccc.2012.07.009

Cited by 2 publications

(2 citation statements)

References 90 publications

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“…The use of dexmedetomidine for post-intubation sedation may lead to bradycardia, so should not be used in patients with ingestions of that cause negative inotropy or chronotropy, such as beta blockers, calcium channel blockers, or alpha-2 agonists [80]. Longer acting agents, such as benzodiazepines, may be beneficial for toxicological cases with a presumed long course, such as alcohol withdrawal, but have been associated with over-sedation [80][81][82].…”

Section: Post-intubation Carementioning

confidence: 99%

Endotracheal Intubation in the Pharmaceutical-Poisoned Patient: a Narrative Review of the Literature

et al. 2020

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Introduction Endotracheal intubation (ETI) is an essential component of the supportive care provided to the critically ill patient with pharmaceutical poisoning; however, specific nuances surrounding intubation including techniques and complications in the context of pharmaceutical poisoning have not been well elucidated. Discussion A search of the available literature on ETI in pharmaceutical-poisoned patients was undertaken using Medline, ERIC, Cochrane database, and PsycINFO using the following MeSH and keyword terms: ("toxicology" OR "poisons" OR "drug overdose" OR "poisoning") AND ("intubation, intratracheal" OR "intubation, endotracheal" OR "airway management" OR "respiration, artificial"). A hand-search was also performed when the literature in the above search required additional conceptual clarification, including using the "Similar Articles" feature of PubMed, along with reviewing articles' reference lists that discussed intubation in the context of a poisoning scenario. Articles with any discussion around the ETI process in the context of a pharmaceutical poisoning were then included. Intubation may be performed in patients poisoned with pharmaceuticals in the context of both single and multiple organ dysfunction including central and peripheral nervous system, pulmonary, or cardiovascular toxicity with hemodynamic instability, or localized effects resulting in mechanical airway obstruction. Certain classes of poisonings may require modifications to the standard rapid sequence induction airway management algorithm. Conclusions ETI is a key component of the supportive care provided to the patient poisoned by a pharmaceutical agent. Clinicians should be aware of the spectrum of toxicities that can necessitate intubation, as well as airway management nuances that are specific to various poisoning presentations.

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Section: Post-intubation Carementioning

confidence: 99%

Endotracheal Intubation in the Pharmaceutical-Poisoned Patient: a Narrative Review of the Literature

et al. 2020

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“…For example, the detection is favourable to the early detection and treatment of diseases (such as myasthenia gravis, etc.). [2][3][4] There are lots of methods to detect acetylcholine, such as fluorescent method, 5 mass spectrometry, 6 chromatography-mass spectrometry, 7 and chemiluminescence method, 8 etc. However, due to the low sensitivity, complex equipment, and poor reversibility, the applicability of the above methods is limited, and they are not suitable for rapid detection and real-time or on-line analysis.…”

Section: Introductionmentioning

confidence: 99%

A Novel Acetylcholine Bioensor and Its Electrochemical Behavior

Wang¹,

Deng²,

Li³

et al. 2013

Journal of Biomedical Nanotechnology

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A novel type of acetylcholine electrochemical biosensor was successfully fabricated by dropping beta-cyclodextrin solution, acetylcholinesterase solution and Nafion-methanol solution to the homemade nano-porous pseudo carbon paste electrode (nano-PPCPE) as working electrode, and then the electrochemical behavior of the as-prepared biosensor was studied through the acetylthiocholine iodide (ATChI). It was shown that the modified nano-PPCPE displays a high selectivity and sensitivity. The acetylcholine biosensor showed the linear range from 5 x 10(-6) M to 2 x 10(-4) M with the detection limit of 1.5 x 10(-7) M.

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Miscellaneous Central Nervous System Intoxicants

Cited by 2 publications

References 90 publications

Endotracheal Intubation in the Pharmaceutical-Poisoned Patient: a Narrative Review of the Literature

Endotracheal Intubation in the Pharmaceutical-Poisoned Patient: a Narrative Review of the Literature

A Novel Acetylcholine Bioensor and Its Electrochemical Behavior

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