Missed Opportunities for Deprescription

Raslan, Ismail A.; McDonald, Emily G.; Lee, Todd C.

doi:10.1001/jamainternmed.2017.1435

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…Fourth, despite deprescribing opportunities, therapeutic inertia is common; true even for low-risk drugs with no withdrawal concerns and more so for drugs with higher risks of harm . Even when adverse events occur, opportunities to deprescribe are not always recognized or acted on . To our knowledge, prior studies of interventions to reduce PIMs while in hospital have tended to be underpowered and nonrandomized or did not capture postdischarge ADEs.…”

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confidence: 99%

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The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults

et al. 2022

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interventions may reduce polypharmacy and the use of potentially inappropriate medications (PIMs); however, few studies have been large enough to evaluate the impact that deprescribing may have on adverse drug events (ADEs).OBJECTIVE To evaluate the effect of an electronic deprescribing decision support tool on ADEs after hospital discharge among older adults with polypharmacy.DESIGN, SETTING, AND PARTICIPANTS This was a cluster randomized clinical trial of older (Ն65 years) hospitalized patients with an expected survival of more than 3 months who were

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Section: Introductionmentioning

confidence: 99%

“…10 Even when adverse events occur, opportunities to deprescribe are not always recognized or acted on. 11,12 To our knowledge, prior studies of interventions to reduce PIMs while in hospital [13][14][15] have tended to be underpowered and nonrandomized or did not capture postdischarge ADEs.…”

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The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults

et al. 2022

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Polypharmacy and Deprescribing in Older Adults

Thompson,

McDonald

2024

Annu. Rev. Med.

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Older adults commonly end up on many medications. Deprescribing is an important part of individualizing care for older adults. It is an opportunity to discuss treatment options and revisit medications that may not have been reassessed in many years. A large evidence base exists in the field, suggesting that deprescribing is feasible and safe, though questions remain about the potential clinical benefits. Deprescribing research faces a myriad of challenges, such as identifying and employing the optimal outcome measures. Further, there is uncertainty about which deprescribing approaches are likely to be most effective and in what contexts. Evidence on barriers and facilitators to deprescribing has underscored how deprescribing in routine clinical practice can be complex and challenging. Thus, finding practical, sustainable ways to implement deprescribing is a priority for future research in the field. Expected final online publication date for the Annual Review of Medicine, Volume 75 is January 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Missed Opportunities for Deprescription

Cited by 2 publications

References 5 publications

The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults

The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults

Polypharmacy and Deprescribing in Older Adults

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