Missense mutation of ISL1 (E283D) is associated with the development of type 2 diabetes

Zhang, Juan; Zhang, Rong; Liu, Chanwei; Ge, Xiaoxu; Wang, Ying; Jiang, Fusong; Zhuang, Langen; Li, Tiantian; Zhu, Qihan; Jiang, Yanyan; Chen, Yating; Lu, Ming; Wang, Yanzhong; Jiang, Meisheng; Liu, Yanjun; Liu, Limei

doi:10.1007/s00125-024-06186-5

Diabetologia

2024

DOI: 10.1007/s00125-024-06186-5

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Missense mutation of ISL1 (E283D) is associated with the development of type 2 diabetes

Juan Zhang,

Rong Zhang,

Chanwei Liu

et al.

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Targeting β-Cell Plasticity: A Promising Approach for Diabetes Treatment

Ghasemi Gojani,

Rai,

Norouzkhani

et al. 2024

CIMB

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The β-cells within the pancreas play a pivotal role in insulin production and secretion, responding to fluctuations in blood glucose levels. However, factors like obesity, dietary habits, and prolonged insulin resistance can compromise β-cell function, contributing to the development of Type 2 Diabetes (T2D). A critical aspect of this dysfunction involves β-cell dedifferentiation and transdifferentiation, wherein these cells lose their specialized characteristics and adopt different identities, notably transitioning towards progenitor or other pancreatic cell types like α-cells. This process significantly contributes to β-cell malfunction and the progression of T2D, often surpassing the impact of outright β-cell loss. Alterations in the expressions of specific genes and transcription factors unique to β-cells, along with epigenetic modifications and environmental factors such as inflammation, oxidative stress, and mitochondrial dysfunction, underpin the occurrence of β-cell dedifferentiation and the onset of T2D. Recent research underscores the potential therapeutic value for targeting β-cell dedifferentiation to manage T2D effectively. In this review, we aim to dissect the intricate mechanisms governing β-cell dedifferentiation and explore the therapeutic avenues stemming from these insights.

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Targeting β-Cell Plasticity: A Promising Approach for Diabetes Treatment

Ghasemi Gojani,

Rai,

Norouzkhani

et al. 2024

CIMB

View full text Add to dashboard Cite

show abstract

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Missense mutation of ISL1 (E283D) is associated with the development of type 2 diabetes

Cited by 1 publication

References 50 publications

Targeting β-Cell Plasticity: A Promising Approach for Diabetes Treatment

Targeting β-Cell Plasticity: A Promising Approach for Diabetes Treatment

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