Mitigating Candidiasis with Acarbose by targeting Candida albicans α-Glucosidase: In- silico, In-vitro and Transcriptomic Approaches
Helma David,
Sahana Vasudevan,
Adline Princy Solomon
Abstract:Biofilm-associated candidiasis poses a significant challenge in clinical settings due to the limited effectiveness of existing antifungal treatments. The challenges include increased pathogen virulence, multi-drug resistance, and inadequate penetration of antimicrobials into biofilm structures. One potential solution to this problem involves the development of novel drugs that can modulate fungal virulence and biofilm formation, which is essential for pathogenesis. Resistance in Candida albicans is initiated b… Show more
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