2021
DOI: 10.1016/j.jaci.2021.03.027
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Mitochondria are involved in bronchial smooth muscle remodeling in severe preschool wheezers

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Cited by 17 publications
(8 citation statements)
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“…Prolonged exposure to PM10 (10 microns) resulted in increased thickness of the basement membrane and eosinophilic inflammation in wheezing children. Increased thickness of the basal membrane was linked to airway smooth muscle cell remodeling and mitochondria mass/activity in pre-school children, who later developed asthma [35]. In addition, this study linked the mitochondria pathology and proliferation to increased intracellular calcium levels in regard to airway wall remodeling.…”
Section: Early Events Leading To Asthma and Airway Wall Remodeling In...mentioning
confidence: 78%
“…Prolonged exposure to PM10 (10 microns) resulted in increased thickness of the basement membrane and eosinophilic inflammation in wheezing children. Increased thickness of the basal membrane was linked to airway smooth muscle cell remodeling and mitochondria mass/activity in pre-school children, who later developed asthma [35]. In addition, this study linked the mitochondria pathology and proliferation to increased intracellular calcium levels in regard to airway wall remodeling.…”
Section: Early Events Leading To Asthma and Airway Wall Remodeling In...mentioning
confidence: 78%
“…Mitochondria, an important organelle, have been linked to the development of asthma with increased levels of ATP content, mitochondrial respiration, mitochondrial mass, reactive oxygen species (ROS), and mitochondrial arginine metabolism detected in asthmatic patients [81][82][83][84]. Additionally, mtDNA has attracted increasing attention in asthma research recently [85].…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, as stated by the authors, if the increased ASMC proliferation in vitro in asthmatics patients compared to non-asthmatics is now well-admitted, its relevance remains unclear due to the divergent results from in vivo studies. As mentioned in the review ( 2 ), an increased ASMC proliferation in vitro has been described by many studies, reviewed by our team in adult asthma ( 1 ) and even in preschool wheezing ( 9 ). This increased ASMC proliferation can be stimulated by several molecules released by inflammatory and bronchial wall cells, including ASMCs themselves, such as growth factors, cytokines, inflammatory mediators, enzymes, but also by free fatty acids, reactive oxygen species, and mechanical stress ( 1 ).…”
mentioning
confidence: 86%
“…By contrast, both the calcium channel inhibitor gallopamil ( 23 ), and the prostaglandin D2 type 2 receptor antagonist fevipiprant ( 24 ) have been showed to significantly decrease airway smooth muscle mass in vivo in double-blind placebo-controlled clinical trials. In addition, it is necessary to clearly indicate that glucocorticoids can decrease some characteristics of bronchial remodeling (e.g., reticular basement thickness, number of bronchial vessels), but are unable to decrease ASMC proliferation in asthma ( 9 , 25 ). Along the same way, bronchodilators were unable to reverse/prevent ASMC proliferation in asthma (unpublished data).…”
mentioning
confidence: 99%