Mitochondria–plasma membrane interactions and communication

Balderas, Pavel Montes de Oca

doi:10.1016/j.jbc.2021.101164

Cited by 29 publications

(17 citation statements)

References 73 publications

(186 reference statements)

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“…The identification of key proteins mediating the crosstalk of mitochondria with their cellular environment is crucial to better understand their tissue-specific regulation and this concept has already attracted considerable interest in recent years (Montes de Oca Balderas, 2021). Although the characterization of local proteomes of organellar contact sites usually require special centrifugation-based isolation methods, we anticipated that a considerable fraction of mitochondria-associated proteins would also enrich along with mitochondria in our samples.…”

Section: Resultsmentioning

confidence: 99%

Mitochondrial phosphoproteomes are functionally specialized across tissues

Hansen

Kremer

Karayel

et al. 2022

Preprint

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Mitochondria are essential organelles involved in critical biological processes such as energy metabolism and cell survival. Their dysfunction is linked to numerous human pathologies that often manifest in a tissue-specific manner. Accordingly, mitochondrial fitness depends on versatile proteomes specialized to meet diverse tissue-specific requirements. Furthermore, increasing evidence suggests that phosphorylation may also play an important role in regulating tissue-specific mitochondrial functions and pathophysiology. We hypothesized that recent advances in mass spectrometry (MS)-based proteomics would now enable in-depth measurement to quantitatively profile mitochondrial proteomes along with their matching phosphoproteomes across tissues. We isolated mitochondria from mouse heart, skeletal muscle, brown adipose tissue, kidney, liver, brain, and spleen by differential centrifugation followed by separation on Percoll gradients and high-resolution MS analysis of the proteomes and phosphoproteomes. This in-depth map substantially quantifies known and predicted mitochondrial proteins and provides a resource of core and tissue modulated mitochondrial proteins (mitophos.de). We also uncover tissue-specific repertoires of dozens of kinases and phosphatases. Predicting kinase substrate associations for different mitochondrial compartments indicates tissue-specific regulation at the phosphoproteome level. Illustrating the functional value of our resource, we reproduce mitochondrial phosphorylation events on DRP1 responsible for its mitochondrial recruitment and fission initiation and describe phosphorylation clusters on MIGA2 linked to mitochondrial fusion.

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Section: Resultsmentioning

confidence: 99%

Mitochondrial phosphoproteomes are functionally specialized across tissues

Hansen

Kremer

Karayel

et al. 2022

Preprint

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“…OCTN1 down-regulation in inflammation could be mediated by cytokines. Data on the action of specific cytokines on OCTN1 expression have been reported in recent papers [ 116 ]. In turn, OCTN1 can regulate the induction of the inflammatory cytokine IL1-β via its substrate [ 117 ].…”

Section: Relevance To Human Pathologymentioning

confidence: 99%

OCTN1: A Widely Studied but Still Enigmatic Organic Cation Transporter Linked to Human Pathology and Drug Interactions

Pochini

Galluccio

Scalise

et al. 2022

IJMS

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The Novel Organic Cation Transporter, OCTN1, is the first member of the OCTN subfamily; it belongs to the wider Solute Carrier family SLC22, which counts many members including cation and anion organic transporters. The tertiary structure has not been resolved for any cation organic transporter. The functional role of OCNT1 is still not well assessed despite the many functional studies so far conducted. The lack of a definitive identification of OCTN1 function can be attributed to the different experimental systems and methodologies adopted for studying each of the proposed ligands. Apart from the contradictory data, the international scientific community agrees on a role of OCTN1 in protecting cells and tissues from oxidative and/or inflammatory damage. Moreover, the involvement of this transporter in drug interactions and delivery has been well clarified, even though the exact profile of the transported/interacting molecules is still somehow confusing. Therefore, OCTN1 continues to be a hot topic in terms of its functional role and structure. This review focuses on the most recent advances on OCTN1 in terms of functional aspects, physiological roles, substrate specificity, drug interactions, tissue expression, and relationships with pathology.

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“…This contact might have an extensive impact on mitochondrial function and cell physiology, but results of these studies are still limited and the molecular bases of this crosstalk are still unclear. Multiple observational studies over the past 50 years have proposed a specific attachment between the mitochondria and PM in neuronal and epithelial cells using electron microscopy, in which the mitochondria-PM contact has been found in close proximity ( Fridolfsson et al, 2012 ; Montes de Oca Balderas, 2021 ).…”

Section: Inter-organelle Communication In I/rmentioning

confidence: 99%

Perspectives on mitochondrial relevance in cardiac ischemia/reperfusion injury

Pedriali

Ramaccini

Bouhamida

et al. 2022

Front. Cell Dev. Biol.

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Cardiovascular disease is the most common cause of death worldwide and in particular, ischemic heart disease holds the most considerable position. Even if it has been deeply studied, myocardial ischemia-reperfusion injury (IRI) is still a side-effect of the clinical treatment for several heart diseases: ischemia process itself leads to temporary damage to heart tissue and obviously the recovery of blood flow is promptly required even if it worsens the ischemic injury. There is no doubt that mitochondria play a key role in pathogenesis of IRI: dysfunctions of these important organelles alter cell homeostasis and survival. It has been demonstrated that during IRI the system of mitochondrial quality control undergoes alterations with the disruption of the complex balance between the processes of mitochondrial fusion, fission, biogenesis and mitophagy. The fundamental role of mitochondria is carried out thanks to the finely regulated connection to other organelles such as plasma membrane, endoplasmic reticulum and nucleus, therefore impairments of these inter-organelle communications exacerbate IRI. This review pointed to enhance the importance of the mitochondrial network in the pathogenesis of IRI with the aim to focus on potential mitochondria-targeting therapies as new approach to control heart tissue damage after ischemia and reperfusion process.

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Mitochondria–plasma membrane interactions and communication

Cited by 29 publications

References 73 publications

Mitochondrial phosphoproteomes are functionally specialized across tissues

Mitochondrial phosphoproteomes are functionally specialized across tissues

OCTN1: A Widely Studied but Still Enigmatic Organic Cation Transporter Linked to Human Pathology and Drug Interactions

Perspectives on mitochondrial relevance in cardiac ischemia/reperfusion injury

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