Mitochondria: Targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants

Teixeira, José; Deus, Cláudia M.; Borges, Fernanda; Oliveira, Paulo J.

doi:10.1016/j.biocel.2018.02.007

Cited by 59 publications

(43 citation statements)

References 28 publications

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“…Overproduction of ROS leads to deficits in mitochondrial membrane integrity, damage to the mitochondrial respiratory chain and lipid peroxidation. Furthermore, injured mitochondria are dysfunctional and further generate free radicals, thus leading a “vicious cycle” . In our studies, exploratory laparotomy disrupted the mitochondrial redox homeostasis and broke the mitochondrial membrane integrity and increased lipid peroxidation in hippocampus, as confirmed by increased mtROS and MDA content, decreased mitochondrial membrane potential (ΔΨ m ), and increased level of cytochrome C from mitochondria to the cytosol.…”

Section: Discussionmentioning

confidence: 57%

“…Furthermore, injured mitochondria are dysfunctional and further generate free radicals, thus leading a "vicious cycle". [47][48][49] In our studies, exploratory laparotomy disrupted the mitochondrial redox homeostasis and broke the mitochondrial membrane integrity and increased lipid peroxidation in hippocampus, as confirmed by increased mtROS and MDA content, decreased mitochondrial membrane potential (Δ ), and increased level of cytochrome C from mitochondria to the cytosol. These results can also be observed in a large number of brain disorders, including stroke, traumatic brain injury, psychiatric disorders, and sepsis-associated encephalopathy as well as AD, PD, and other neurodegenerative diseases.…”

Section: Effects Of Honokiol On Sirt3/sod2 Signaling Pathwaymentioning

confidence: 50%

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SIRT3 activator honokiol ameliorates surgery/anesthesia‐induced cognitive decline in mice through anti‐oxidative stress and anti‐inflammatory in hippocampus

Chen

et al. 2018

CNS Neurosci Ther

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Aims Increasing evidence indicates that neuroinflammatory and oxidative stress play two pivotal roles in cognitive impairment after surgery. Honokiol (HNK), as an activator of Sirtuin3 (SIRT3), has potential multiple biological functions. The aim of these experiments is to evaluate the effects of HNK on surgery/anesthesia‐induced cognitive decline in mice. Methods Adult C57BL/6 mice received a laparotomy under sevoflurane anesthesia and HNK or SIRT3 inhibitor (3‐TYP) treatment. Cognitive function and locomotor activity of mice were evaluated using fear conditioning test and open field test on postoperative 1 and 3 days. Neuronal apoptosis in CA1 and CA3 area of hippocampus was examined using TUNEL assay. And Western blot was applied to measure the expression of pro‐inflammatory cytokines and SIRT3/SOD2 signaling‐associated proteins in hippocampus. Meanwhile, SIRT3 positive cells were calculated by immunohistochemistry. The mitochondrial membrane potential, malondialdehyde (MDA), and mitochondrial radical oxygen species (mtROS) were detected using standard methods. Results Honokiol attenuated surgery‐induced memory loss and neuronal apoptosis, decreased neuroinflammatory response, and ameliorated oxidative damage in hippocampus. Notably, surgery/anesthesia induced an obviously decrease in hippocampal SIRT3 expression, whereas the HNK increased SIRT3 expression and thus decreased the acetylation of superoxide dismutase 2 (SOD2). However, 3‐TYP treatment inhibited the HNK's rescuing effects. Conclusions These results suggested that activation of SIRT3 by honokiol may attenuate surgery/anesthesia‐induced cognitive impairment in mice through regulation of oxidative stress and neuroinflammatory in hippocampus.

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Section: Discussionmentioning

confidence: 57%

Section: Effects Of Honokiol On Sirt3/sod2 Signaling Pathwaymentioning

confidence: 50%

SIRT3 activator honokiol ameliorates surgery/anesthesia‐induced cognitive decline in mice through anti‐oxidative stress and anti‐inflammatory in hippocampus

Chen

et al. 2018

CNS Neurosci Ther

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“…It has been confirmed that SIRT1 and pGC-1a promote mitochondrial regeneration and energy metabolism by modulating multiple steps in AMPK/FoXO1 pathways [37]. Additionally, the role of G6 in the SIRT1 signaling pathway was explored using RT-PCR assays.…”

Section: Effects Of G6 On the Mrna Expression Of Sirt1 Pathwaysmentioning

confidence: 96%

Protective Effect of l-Hexaguluroic Acid Hexasodium Salt on UVA-Induced Photo-Aging in HaCaT Cells

Bai

Qin

et al. 2020

IJMS

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This study aimed to show the α-l-Hexaguluroic acid hexasodium salt (G6) protective effect against UVA-induced photoaging of human keratinocyte cells. We found that G6 localized to the mitochondria and improved mitochondrial functions. G6 increased respiratory chain complex activities, which led to increased cellular ATP content and NAD + /NADH ratio. Thus, G6 alleviated the oxidative stress state in UVA-irradiated cells. Moreover, G6 can regulate the SIRT1/pGC-1α pathway, which enhanced the cells' viability and mitochondria energy metabolism. Notably, the anti-photoaging potential of G6 was directly associated with the increased level of MMP and SIRT1, which was followed by the upregulation of pGC-1α, D-LOOP, and Mt-TFA, and with the transcriptional activation of NRF1/NRF2. Taking all of the results together, we conclude that G6 could protect HaCaT cells from UVA-induced photo-aging via the regulation of mitochondria energy metabolism and its downstream signaling pathways.Int. J. Mol. Sci. 2020, 21, 1201 2 of 16 breathing, a small fraction of electrons may "leak" from the electron transport chain (ETC), especially from complexes I and III reduce oxygen to form ROS [13]. Other mitochondrial proteins, such as alpha-glycerophosphate dehydrogenase, alpha-ketoglutarate, and pyruvate dehydrogenase, have been shown to play a role in ROS production [14]. The mitochondria are also the only organelle in animal cells that have their own mtDNA, which is located physically close to the mitochondrial respiratory chain (MRC). Moreover, those point mutations and deletions in mtDNA were reported to accumulate more and more in various tissues during aging [15], which might consequently lead to the declined MRC capacity in various tissues, such as the skeletal muscle and liver [16,17]. In addition, the fact that the mitochondrial ETC is the major ROS production site results in mitochondria being the primary target for oxidative damage. Related studies have shown that with age, mitochondria become larger, decrease in the number, accumulate vacuoles, sputum abnormalities, and experience mitochondrial rupture [18,19].More importantly, oxidative damage of protein and mtDNA, accompanied by mtDNA mutations, could result in a decrease in mitochondrial respiratory chain enzyme activities, mitochondrial membrane potential, and ATP production [19]. It has been demonstrated that creatine enhances DNA repair caused by UV-induced stress exposure in skin models [20]. Notably, in human clinical settings, formulations containing creatine, acetyl l-carnitine, and NADH can reduce the appearance of aging [21]. The researchers believe that the repair is due to the increased availability of ATP provided by creatine. Under the pressure of ultraviolet light, cells can use this additional ATP to synthesize the required repair enzymes [20,21].Meanwhile, ultraviolet irradiation can also induce the expression of the ROS production, leading to skin inflammation and downregulation of SIRT1 [22]. It has been reported that an enhancement in sirtuin genes and pGC...

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“…Testing other antioxidants, such as 10-(6′-plastoquinonyl) decyltriphenylphosphonium (SkQ1), MitoQuercetin, Mitocurcumin, Mitoresveratrol, MitoHonokiol, Mitoapocynin, AntiOxCIN4, AntiOxBEN2, could anyway prove beneficial in ALS, more importantly in the models where the antioxidant system is disrupted (Teixeira, Deus, Borges, & Oliveira, 2018).…”

Section: Oxysterols -Schrodinger's Cat Of Mitochondrial Cholesterolmentioning

confidence: 99%

“…).AntiOxBEN2, could anyway prove beneficial in ALS, more importantly in the models where the antioxidant system is disrupted(Teixeira, Deus, Borges, & Oliveira, 2018).After almost two decades since the approval of riluzole for ALS, another agent, edaravone, was only recently approved by the FDA (May 2017), after showing benefit in a randomized double-blind clinical trial(Rothstein, 2017;Writing & Edaravone, 2017). While edaravone has other effects, such as reducing inflammation, its main activity is antioxidant.…”

mentioning

confidence: 99%

Exploring mitochondrial cholesterol signalling for therapeutic intervention in neurological conditions

Desai

Campanella

2019

British J Pharmacology

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The pharmacological targeting of cholesterol levels continues to generate interest due to the undoubted success of therapeutic agents, such as statins, in extending life expectancy by modifying the prognosis of diseases associated with the impairment of lipid metabolism. Advances in our understanding of mitochondrial dysfunction in chronic age‐related diseases of the brain have disclosed an emerging role for mitochondrial cholesterol in their pathophysiology, thus delineating an opportunity to provide mechanistic insights and explore strategies of intervention. This review draws attention to novel signalling mechanisms in conditions linked with impaired metabolism associated with impaired handling of cholesterol and its oxidized forms (oxysterols) by mitochondria. By emphasizing the role of mitochondrial cholesterol in neurological diseases, we here call for novel approaches and new means of assessment. Linked Articles This article is part of a themed section on Mitochondrial Pharmacology: Featured Mechanisms and Approaches for Therapy Translation. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.22/issuetoc

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Mitochondria: Targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants

Cited by 59 publications

References 28 publications

SIRT3 activator honokiol ameliorates surgery/anesthesia‐induced cognitive decline in mice through anti‐oxidative stress and anti‐inflammatory in hippocampus

SIRT3 activator honokiol ameliorates surgery/anesthesia‐induced cognitive decline in mice through anti‐oxidative stress and anti‐inflammatory in hippocampus

Protective Effect of l-Hexaguluroic Acid Hexasodium Salt on UVA-Induced Photo-Aging in HaCaT Cells

Exploring mitochondrial cholesterol signalling for therapeutic intervention in neurological conditions

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