Mitochondrial and microsomal cholesterol mobilization after oxidative stress induced by adriamycin in rats fed with dietary olive and corn oil

Huertas, Jesús R.; Battino, Maurizio; Barzanti, V.; Maranesi, Magda; Parenti-Castelli, G; Littarru, G. P.; Turchetto, E; Mataix, F. J.; Lenaz, Giorgio

doi:10.1016/0024-3205(92)90577-c

Cited by 32 publications

(16 citation statements)

References 41 publications

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“…Alternatively, even though opposite changes in MUFA and PUFA composition of liver mitochondrial membranes occurred after physical exercise, membrane fluidity remained the same (results not shown), which suggests that a counterbalance effect was achieved as has been postulated by other authors (Periago et al 1990;Huertas et al 1992).…”

Section: N-3 Polyunsaturated Fatty Acidssupporting

confidence: 50%

Physical exercise affects the lipid profile of mitochondrial membranes in rats fed with virgin olive oil or sunflower oil

et al. 1999

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The effects of physical exercise on the lipid profile in mitochondrial membranes of liver and skeletal muscle were examined in rats fed with virgin olive oil or sunflower oil. Thirty male Wistar rats, 21 d old, were randomly assigned to four groups according to fat ingestion and physical activity over an 8-week period. For each type of oil, one group acted as a control group while rats from the other were trained to run for 40 min daily on a horizontal treadmill, at a speed of 35 m/min. The results show that diet affected the fatty acid profile of the mitochondrial membranes from skeletal muscle and liver. Physical exercise also modified the fatty acid profile of the mitochondrial membranes. Total monounsaturated fatty acids decreased (P < 0 : 001) in liver mitochondria of exercised animals. Total polyunsaturated fatty acids in mitochondrial membranes of liver increased (P < 0 : 005) after exercise but those in mitochondrial membranes of skeletal muscle decreased (P < 0 : 05). These changes due to the exercise may arise via several mechanisms, e.g. fluidity regulation; changes in the eicosanoid metabolism; differences in the availability or oxidation rate of the different fatty acids. Liver: Skeletal muscle: Dietary fat: Exercise

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Section: N-3 Polyunsaturated Fatty Acidssupporting

confidence: 50%

Physical exercise affects the lipid profile of mitochondrial membranes in rats fed with virgin olive oil or sunflower oil

et al. 1999

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“…A number of dietary substances may affect the susceptibility of cell and cell organelles, as well as plasma lipoproteins, to lipid peroxidation [4,20,25]. Likewise, it has been demonstrated that the intake of xenobiotic agents may upset the equilibrium between pro-oxidant and antioxidant factors [6,13,32].…”

Section: Discussionmentioning

confidence: 99%

An ethanolic‐aqueous extract of Curcuma longa decreases the susceptibility of liver microsomes and mitochondria to lipid peroxidation in atherosclerotic rabbits

et al. 1998

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Atherosclerosis is characterized by oxidative damage which affects lipoproteins, the walls of blood vessels and subcellular membranes. This study evaluates the antioxidant capacity of a Curcuma longa extract on the lipid peroxidation of liver mitochondria and microsome membranes in atherosclerotic rabbits. Male rabbits fed a 3% (w/w) lard and 1.3% (w/w) cholesterol diet were randomly assigned to three groups. Two groups were treated with different dosages of a turmeric extract (A and B) and the third group (control) with a curcumin-free solution. Basal and in vitro 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced hydroperoxide and TBARS productions in liver mitochondria and microsomes were analyzed. Group A had the lowest concentration of mitochondrial hydroperoxides. In microsomes, the basal hydroperoxide levels were similar in all groups but, after the induction of oxidation, group C registered the highest value; TBARS production followed the same trend in mitochondria. These findings suggest that active compounds in curcuma extract may be protective in preventing lipoperoxidation of subcellular membranes in a dosage-dependent manner.

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“…Moreover, antioxidant status of laying Japanese quails fed OP and/or A. awamori was improved (P < 0.01); significant increase in serum GSH value and GSR activity, and decrease in TBARS content were noticed in groups fed OP with or without A. awamori. Earlier, previous researches had proved that some oil sources (e.g., fish, soybean and olive oil), especially that have high content of oleic acid, exert potential detrimental effects on animals by increasing susceptibility to lipid or protein peroxidation in liver mitochondria (Huertas et al, 1992;Ochoa-Herrera et al, 2001;Quiles et al, 2006;Dong et al, 2018). So, we measured the serum values of AST and ALT as biomarkers for liver health in order to ensure the absence of any side effects on the liver exerted from the tested supplemental doses.…”

Section: Serum Biochemical Parametersmentioning

confidence: 99%

Beneficial effect of feeding olive pulp and <i>Aspergillus awamori</i> on productive performance, egg quality, serum/yolk cholesterol and oxidative status in laying Japanese quails

El-Moneim¹,

Sabic²

2019

J. Anim. Feed Sci.

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Mitochondrial and microsomal cholesterol mobilization after oxidative stress induced by adriamycin in rats fed with dietary olive and corn oil

Cited by 32 publications

References 41 publications

Physical exercise affects the lipid profile of mitochondrial membranes in rats fed with virgin olive oil or sunflower oil

Physical exercise affects the lipid profile of mitochondrial membranes in rats fed with virgin olive oil or sunflower oil

An ethanolic‐aqueous extract of Curcuma longa decreases the susceptibility of liver microsomes and mitochondria to lipid peroxidation in atherosclerotic rabbits

Beneficial effect of feeding olive pulp and <i>Aspergillus awamori</i> on productive performance, egg quality, serum/yolk cholesterol and oxidative status in laying Japanese quails

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