Mitochondrial and transcriptome responses in rat dopaminergic neuronal cells following exposure to the insecticide fipronil

Souders, Christopher L.; Rushin, Anna; Sanchez, Christina L.; Toth, Darby; Adamovský, Ondřej; Martyniuk, Christopher J.

doi:10.1016/j.neuro.2021.05.011

Cited by 10 publications

(2 citation statements)

References 31 publications

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“…Likewise, Souders et al (2021) reported malformation of the nervous system, neurofibrillary tangles, neuroinflammation, and nerve fiber degeneration in neuronal cells of rats exposed to fipronil [ 54 ]. Moreover, Cam et al, (2018) have demonstrated that fipronil stimulated the production of amyloid peptides which constitute a characteristic abnormality in Alzheimer’s disease [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

The Association between Pesticide Exposure and the Development of Fronto-Temporal Dementia-Cum-Dissociative Disorders: A Review

Flores-Gutierrez,

Torres-Sanchez,

Reyes-Uribe

et al. 2023

Brain Sciences

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Pesticides are chemicals used in agricultural fields for the prevention or destruction of pests. Inappropriate use of these substances, as well as handling them without using personal protective equipment, may result in serious health problems such as neurodegenerative diseases and mental disorders. Previous studies have demonstrated the adverse effects of pesticides on brain function. However, some researchers have associated pesticide poisoning with the development of disorders such as dissociative amnesia, multiple personality disorders, and depersonalization disorder. The objective of this work was to perform a bibliographic review of the relationship between pesticide poisoning and the development of dissociative disorders. Previous studies suggest that the duration of pesticide exposure is a major determinant in the development of dissociative diseases and disorders. The information obtained in this review suggests that there is no specific relationship between dissociative disorders and pesticide poisoning. However, these results point to associating the most representative symptoms of dissociative disorder (such as amnesia and memory loss) with pesticide exposure. Based on the bibliographic search, possible mechanisms of action were suggested in an attempt to explain a possible association between exposure to pesticides and the appearance of dissociative disorders.

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Section: Discussionmentioning

confidence: 99%

The Association between Pesticide Exposure and the Development of Fronto-Temporal Dementia-Cum-Dissociative Disorders: A Review

Flores-Gutierrez,

Torres-Sanchez,

Reyes-Uribe

et al. 2023

Brain Sciences

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“…Additionally, Wu et al (2021) reported increased levels of TNF-α in the brain tissue of zebrafish following fipronil exposure, a widely used broad-spectrum insecticide, indicating neuroinflammation [21]. Likewise, Souders II et al ( 2021) documented increased levels of inducible nitric oxide (NO) synthase, cyclooxygenase-2, and TNF-α, supporting the hypothesis of pesticide-induced neuroinflammation [22].…”

Section: Pesticide-triggered Effects On the Immune Systemmentioning

confidence: 95%

Pesticide-Induced Inflammation at a Glance

Lopes-Ferreira,

Farinha,

Costa

et al. 2023

Toxics

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The increasing number of studies reporting the risks of the exposure to pesticides aligned with the intensified use of such hazardous chemicals has emerged as a pressing contemporary issue, notably due to the potential effects to both the environment and human health. Pesticides, while broadly applied in modern agriculture for pest control and crop protection, have raised concerns due to their unintended effects on non-target organisms. The immune system exerts a key role in the protection against the exposome, which could result in cellular imbalances and tissue damage through the inflammatory response. Pesticides, which encompass a diverse array of chemicals, have been linked to inflammation in experimental models. Therefore, the aim of this review is to discuss the increasing concern over the risks of pesticide exposure focusing on the effects of various chemical classes on inflammation by covering, as broadly as possible, different experimental approaches as well as the multiple or co-exposure of pesticides. Overall, pesticides potentially induce inflammation in different experimental models, manifested through skin irritation, respiratory impairment, or systemic effects. The connection between pesticides and inflammation highlights the importance of proper handling and regulation of these substances and underscores the need for research into safer and sustainable practices to reduce our reliance on synthetic pesticides and fertilizers.

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Toxicity assessment of carvacrol and its acetylated derivative in early staged zebrafish (Danio rerio): Safer alternatives to fipronil-based pesticides?

Konig,

Iftikhar,

Henry

et al. 2023

Comparative Biochemistry and Physiology Part C: Toxicology &

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Mitochondrial and transcriptome responses in rat dopaminergic neuronal cells following exposure to the insecticide fipronil

Cited by 10 publications

References 31 publications

The Association between Pesticide Exposure and the Development of Fronto-Temporal Dementia-Cum-Dissociative Disorders: A Review

The Association between Pesticide Exposure and the Development of Fronto-Temporal Dementia-Cum-Dissociative Disorders: A Review

Pesticide-Induced Inflammation at a Glance

Toxicity assessment of carvacrol and its acetylated derivative in early staged zebrafish (Danio rerio): Safer alternatives to fipronil-based pesticides?

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