Mitochondrial Bioenergetics in Different Pathophysiological Conditions 2.0

Valenti, Daniela; Atlante, Anna

doi:10.3390/ijms23105552

Cited by 2 publications

(1 citation statement)

References 20 publications

(33 reference statements)

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“…Mitochondrial signal transduction ensures organismal adaptation, underscoring the importance of mitochondrial biology in human health [15]. In addition, mitochondria are highly dynamic and play a vital role in maintaining cellular energy metabolism by producing energy in the form of ATP via oxidative phosphorylation (OXPHOS) through the electron transport chain (ETC) [16]. Furthermore, through fusion and fission, mitochondria form dynamic tubular networks to respond to external stress by eliminating dysfunctional mitochondria while producing healthy ones so as to maintain regular function and prevent disease [17].…”

Section: Introductionmentioning

confidence: 99%

Nanodrug Delivery Systems for Myasthenia Gravis: Advances and Perspectives

Huang,

Yan,

Song

et al. 2024

Pharmaceutics

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Myasthenia gravis (MG) is a rare chronic autoimmune disease caused by the production of autoantibodies against the postsynaptic membrane receptors present at the neuromuscular junction. This condition is characterized by fatigue and muscle weakness, including diplopia, ptosis, and systemic impairment. Emerging evidence suggests that in addition to immune dysregulation, the pathogenesis of MG may involve mitochondrial damage and ferroptosis. Mitochondria are the primary site of energy production, and the reactive oxygen species (ROS) generated due to mitochondrial dysfunction can induce ferroptosis. Nanomedicines have been extensively employed to treat various disorders due to their modifiability and good biocompatibility, but their application in MG management has been rather limited. Nevertheless, nanodrug delivery systems that carry immunomodulatory agents, anti-oxidants, or ferroptosis inhibitors could be effective for the treatment of MG. Therefore, this review focuses on various nanoplatforms aimed at attenuating immune dysregulation, restoring mitochondrial function, and inhibiting ferroptosis that could potentially serve as promising agents for targeted MG therapy.

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Section: Introductionmentioning

confidence: 99%